scholarly journals Physiologic corticosterone oscillations regulate murine hematopoietic stem/progenitor cell proliferation and CXCL12 expression by bone marrow stromal progenitors

Leukemia ◽  
2013 ◽  
Vol 27 (10) ◽  
pp. 2006-2015 ◽  
Author(s):  
O Kollet ◽  
Y Vagima ◽  
G D'Uva ◽  
K Golan ◽  
J Canaani ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cell Proliferation ◽  
Progenitor Cell ◽  
Cxcl12 Expression ◽  
Hematopoietic Stem ◽  
Progenitor Cell Proliferation

scholarly journals DEK Regulates Hematopoietic Stem Engraftment and Progenitor Cell Proliferation

2012 ◽  
Vol 21 (9) ◽  
pp. 1449-1454 ◽  
Author(s):  
Hal E. Broxmeyer ◽  
Ferdinand Kappes ◽  
Nirit Mor-Vaknin ◽  
Maureen Legendre ◽  
John Kinzfogl ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Progenitor Cell ◽  
Hematopoietic Stem ◽  
Progenitor Cell Proliferation

scholarly journals Mobilization of CD34+ Progenitor Cells in Association with Decreased Proliferation in the Bone Marrow of Macaques after Administration of the Fms-Like Tyrosine Kinase 3 Ligand

2010 ◽  
Vol 17 (8) ◽  
pp. 1269-1273 ◽  
Author(s):  
R. Keith Reeves ◽  
Qing Wei ◽  
Patricia N. Fultz
Keyword(s):  
Bone Marrow ◽  
Cell Proliferation ◽  
Tyrosine Kinase ◽  
Progenitor Cells ◽  
Progenitor Cell ◽  
Flow Cytometric ◽  
Progenitor Cell Proliferation ◽  
Cell Mobilization ◽  
Negative Regulatory Mechanism

ABSTRACT Fms-like tyrosine kinase 3 ligand (FLT3-L) is critical for the differentiation and self-renewal of CD34+ progenitor cells in primates and has been used therapeutically to mobilize progenitor and dendritic cells in vivo. However, little is known regarding the expansion of progenitor cells outside of peripheral blood, particularly in bone marrow (BM), where progenitor cells primarily reside. Evaluation of FLT3-L-mediated cell mobilization during lentivirus infections, where the numbers of CD34+ progenitor cells are reduced, is limited. We enumerated frequencies and absolute numbers of CD34+ progenitor cells in blood and BM of naive and SIV- or SHIV-infected macaques during and after the administration of FLT3-L. Flow cytometric analyses revealed that, while CD34+ cells increased in the circulation, no expansion was observed in BM. Furthermore, in the BM intracellular Ki67, a marker of cell proliferation, was downregulated in CD34+ progenitor cells but was upregulated significantly in the bulk cell population. Although the exact mechanism(s) remains unclear, these data suggest that CD34+ cell mobilization in blood was the result of cellular emigration from BM and not the proliferation of CD34+ cells already in the periphery. It is possible that the decreased progenitor cell proliferation observed in BM is evidence of a negative regulatory mechanism preventing hyperproliferation and development of neoplastic cells.

scholarly journals TLR5 signaling in murine bone marrow induces hematopoietic progenitor cell proliferation and aids survival from radiation

2017 ◽  
Vol 1 (21) ◽  
pp. 1796-1806 ◽  
Author(s):  
Benyue Zhang ◽  
Damilola Oyewole-Said ◽  
Jun Zou ◽  
Ifor R. Willliams ◽  
Andrew T. Gewirtz
Keyword(s):  
Bone Marrow ◽  
Cell Proliferation ◽  
Progenitor Cell ◽  
Hematopoietic Progenitor Cell ◽  
Mouse Bone Marrow ◽  
Hematopoietic Progenitor ◽  
Murine Bone Marrow ◽  
Key Points ◽  
Progenitor Cell Proliferation ◽  
Lethal Irradiation

Key Points Flagellin activates TLR5 signaling in mouse bone marrow and induces hematopoietic progenitor cell proliferation. Flagellin-induced MPP3 cells aid the survival of mice exposed to lethal irradiation.

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