Cytotoxic activity of the novel Akt inhibitor, MK-2206, in T-cell acute lymphoblastic leukemia

C Simioni; L M Neri; G Tabellini; F Ricci; D Bressanin; F Chiarini; C Evangelisti; A Cani; P L Tazzari; F Melchionda; P Pagliaro; A Pession; J A McCubrey; S Capitani; A M Martelli

doi:10.1038/leu.2012.136

Cytotoxic activity of the novel Akt inhibitor, MK-2206, in T-cell acute lymphoblastic leukemia

Leukemia ◽

10.1038/leu.2012.136 ◽

2012 ◽

Vol 26 (11) ◽

pp. 2336-2342 ◽

Cited By ~ 50

Author(s):

C Simioni ◽

L M Neri ◽

G Tabellini ◽

F Ricci ◽

D Bressanin ◽

...

Keyword(s):

Acute Lymphoblastic Leukemia ◽

T Cell ◽

Cytotoxic Activity ◽

Lymphoblastic Leukemia ◽

The Novel ◽

Akt Inhibitor ◽

Cell Acute Lymphoblastic Leukemia

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Proapoptotic Activity and Chemosensitizing Effect of the Novel Akt Inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-Cell Acute Lymphoblastic Leukemia

Molecular Pharmacology ◽

10.1124/mol.108.047639 ◽

2008 ◽

Vol 74 (3) ◽

pp. 884-895 ◽

Cited By ~ 24

Author(s):

Federica Falà ◽

William L. Blalock ◽

Pier Luigi Tazzari ◽

Alessandra Cappellini ◽

Francesca Chiarini ◽

...

Keyword(s):

Acute Lymphoblastic Leukemia ◽

T Cell ◽

Lymphoblastic Leukemia ◽

The Novel ◽

Akt Inhibitor ◽

Cell Acute Lymphoblastic Leukemia

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Abstract 3750: The novel Akt inhibitor MK-2206, is cytotoxic in T-cell acute lymphoblastic leukemia: Therapeutic implications

10.1158/1538-7445.am2012-3750 ◽

2012 ◽

Cited By ~ 1

Author(s):

Carolina Simioni ◽

Alice Cani ◽

Daniela Bressanin ◽

Camilla Evangelisti ◽

Francesca Chiarini ◽

...

Keyword(s):

Acute Lymphoblastic Leukemia ◽

T Cell ◽

Lymphoblastic Leukemia ◽

The Novel ◽

Akt Inhibitor ◽

Therapeutic Implications ◽

Cell Acute Lymphoblastic Leukemia

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Preclinical testing of the Akt inhibitor triciribine in T-cell acute lymphoblastic leukemia

Journal of Cellular Physiology ◽

10.1002/jcp.22407 ◽

2010 ◽

Vol 226 (3) ◽

pp. 822-831 ◽

Cited By ~ 45

Author(s):

Camilla Evangelisti ◽

Francesca Ricci ◽

Pierluigi Tazzari ◽

Francesca Chiarini ◽

Michela Battistelli ◽

...

Keyword(s):

Acute Lymphoblastic Leukemia ◽

T Cell ◽

Lymphoblastic Leukemia ◽

Akt Inhibitor ◽

Preclinical Testing ◽

Cell Acute Lymphoblastic Leukemia

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Identification of the novel AML1 fusion partner gene, LAF4, a fusion partner of MLL, in childhood T-cell acute lymphoblastic leukemia with t(2;21)(q11;q22) by bubble PCR method for cDNA

Oncogene ◽

10.1038/sj.onc.1210857 ◽

2007 ◽

Vol 27 (15) ◽

pp. 2249-2256 ◽

Cited By ~ 22

Author(s):

Y Chinen ◽

T Taki ◽

K Nishida ◽

D Shimizu ◽

T Okuda ◽

...

Keyword(s):

Acute Lymphoblastic Leukemia ◽

T Cell ◽

Lymphoblastic Leukemia ◽

Fusion Partner ◽

The Novel ◽

Partner Gene ◽

Cell Acute Lymphoblastic Leukemia ◽

Pcr Method

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Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling

Leukemia ◽

10.1038/leu.2013.349 ◽

2013 ◽

Vol 28 (3) ◽

pp. 543-553 ◽

Cited By ~ 51

Author(s):

F Buontempo ◽

E Orsini ◽

L R Martins ◽

I Antunes ◽

A Lonetti ◽

...

Keyword(s):

Acute Lymphoblastic Leukemia ◽

T Cell ◽

Cytotoxic Activity ◽

Unfolded Protein Response ◽

Lymphoblastic Leukemia ◽

Casein Kinase ◽

Unfolded Protein ◽

Cell Acute Lymphoblastic Leukemia ◽

The Unfolded Protein Response ◽

Protein Response

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Activity of the Novel Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 against T-Cell Acute Lymphoblastic Leukemia

Cancer Research ◽

10.1158/0008-5472.can-10-1814 ◽

2010 ◽

Vol 70 (20) ◽

pp. 8097-8107 ◽

Cited By ~ 122

Author(s):

Francesca Chiarini ◽

Cecilia Grimaldi ◽

Francesca Ricci ◽

Pier Luigi Tazzari ◽

Camilla Evangelisti ◽

...

Keyword(s):

Acute Lymphoblastic Leukemia ◽

T Cell ◽

Lymphoblastic Leukemia ◽

Mammalian Target Of Rapamycin ◽

Target Of Rapamycin ◽

The Novel ◽

Phosphatidylinositol 3 Kinase ◽

Cell Acute Lymphoblastic Leukemia ◽

Phosphatidylinositol 3

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Faculty Opinions recommendation of Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717970131.793468747 ◽

2013 ◽

Author(s):

Philip Mason

Keyword(s):

Acute Lymphoblastic Leukemia ◽

T Cell ◽

Exome Sequencing ◽

Lymphoblastic Leukemia ◽

Ribosomal Genes ◽

Cell Acute Lymphoblastic Leukemia

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Faculty Opinions recommendation of Children's Oncology Group AALL0434: A Phase III Randomized Clinical Trial Testing Nelarabine in Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.738522524.793577966 ◽

2020 ◽

Author(s):

Ching-Hon Pui

Keyword(s):

Clinical Trial ◽

Acute Lymphoblastic Leukemia ◽

T Cell ◽

Randomized Clinical Trial ◽

Lymphoblastic Leukemia ◽

Phase Iii ◽

Newly Diagnosed ◽

Oncology Group ◽

Trial Testing ◽

Cell Acute Lymphoblastic Leukemia

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Inactivation of KLF4 promotes T-cell acute lymphoblastic leukemia and activates the MAP2K7 pathway that can be targeted for therapy

European Journal of Cancer ◽

10.1016/s0959-8049(16)32937-9 ◽

2016 ◽

Vol 69 ◽

pp. S113

Author(s):

Y. Shen ◽

C.S. Park ◽

K. Suppipat ◽

T.A. Mistretta ◽

M. Puppi ◽

...

Keyword(s):

Acute Lymphoblastic Leukemia ◽

T Cell ◽

Lymphoblastic Leukemia ◽

Cell Acute Lymphoblastic Leukemia

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Interleukin-2 priming chemotherapy: A strategy to improve the remission of refractory/relapsed T cell acute lymphoblastic leukemia

Medical Hypotheses ◽

10.1016/j.mehy.2013.08.037 ◽

2013 ◽

Vol 81 (5) ◽

pp. 878-880

Author(s):

Cheng Zhang ◽

Xi Zhang ◽

Xing-Hua Chen

Keyword(s):

Acute Lymphoblastic Leukemia ◽

T Cell ◽

Lymphoblastic Leukemia ◽

Interleukin 2 ◽

Cell Acute Lymphoblastic Leukemia

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