(+)α-Tocopheryl succinate inhibits the mitochondrial respiratory chain complex I and is as effective as arsenic trioxide or ATRA against acute promyelocytic leukemia in vivo

G A S dos Santos; R S Abreu e Lima; C R Pestana; A S G Lima; P S Scheucher; C H Thomé; H L Gimenes-Teixeira; B A A Santana-Lemos; A R Lucena-Araujo; F P Rodrigues; R Nasr; S A Uyemura; R P Falcão; H de Thé; P P Pandolfi; C Curti; E M Rego

doi:10.1038/leu.2011.216

(+)α-Tocopheryl succinate inhibits the mitochondrial respiratory chain complex I and is as effective as arsenic trioxide or ATRA against acute promyelocytic leukemia in vivo

Leukemia ◽

10.1038/leu.2011.216 ◽

2011 ◽

Vol 26 (3) ◽

pp. 451-460 ◽

Cited By ~ 32

Author(s):

G A S dos Santos ◽

R S Abreu e Lima ◽

C R Pestana ◽

A S G Lima ◽

P S Scheucher ◽

...

Keyword(s):

Arsenic Trioxide ◽

Acute Promyelocytic Leukemia ◽

Complex I ◽

Chain Complex ◽

Mitochondrial Respiratory Chain ◽

Promyelocytic Leukemia ◽

Respiratory Chain Complex ◽

Mitochondrial Respiratory Chain Complex ◽

Tocopheryl Succinate

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A case of Ohtahara syndrome with mitochondrial respiratory chain complex I deficiency

Brain and Development ◽

10.1016/j.braindev.2008.12.020 ◽

2010 ◽

Vol 32 (3) ◽

pp. 253-257 ◽

Cited By ~ 25

Author(s):

Joo Hee Seo ◽

Young Mock Lee ◽

Joon Soo Lee ◽

Se Hoon Kim ◽

Heung Dong Kim

Keyword(s):

Respiratory Chain ◽

Complex I ◽

Chain Complex ◽

Mitochondrial Respiratory Chain ◽

Respiratory Chain Complex ◽

Mitochondrial Respiratory Chain Complex ◽

Complex I Deficiency ◽

Ohtahara Syndrome ◽

Mitochondrial Respiratory

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Inhibition of mitochondrial respiratory chain complex I by TNF results in cytochrome c release, membrane permeability transition, and apoptosis

Oncogene ◽

10.1038/sj.onc.1202485 ◽

1998 ◽

Vol 17 (19) ◽

pp. 2515-2524 ◽

Cited By ~ 91

Author(s):

Masahiro Higuchi ◽

Rita J Proske ◽

Edward TH Yeh

Keyword(s):

Cytochrome C ◽

Membrane Permeability ◽

Complex I ◽

Chain Complex ◽

Permeability Transition ◽

Mitochondrial Respiratory Chain ◽

Respiratory Chain Complex ◽

Cytochrome C Release ◽

Membrane Permeability Transition ◽

Mitochondrial Respiratory Chain Complex

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Acadian variant of Fanconi syndrome is caused by mitochondrial respiratory chain complex I deficiency due to a non-coding mutation in complex I assembly factor NDUFAF6

Human Molecular Genetics ◽

10.1093/hmg/ddw245 ◽

2016 ◽

Vol 25 (18) ◽

pp. 4062-4079 ◽

Cited By ~ 26

Author(s):

Hana Hartmannová ◽

Lenka Piherová ◽

Kateřina Tauchmannová ◽

Kendrah Kidd ◽

Philip D. Acott ◽

...

Keyword(s):

Respiratory Chain ◽

Complex I ◽

Fanconi Syndrome ◽

Chain Complex ◽

Mitochondrial Respiratory Chain ◽

Respiratory Chain Complex ◽

Mitochondrial Respiratory Chain Complex ◽

Complex I Deficiency ◽

Assembly Factor ◽

Complex I Assembly

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Characterization of Arabidopsis mutant with inactivated gene coding for Fe-S subunit of mitochondrial respiratory chain complex I

Russian Journal of Plant Physiology ◽

10.1134/s1021443710030118 ◽

2010 ◽

Vol 57 (3) ◽

pp. 392-400 ◽

Cited By ~ 5

Author(s):

V. I. Tarasenko ◽

E. Yu. Garnik ◽

Yu. M. Konstantinov

Keyword(s):

Respiratory Chain ◽

Complex I ◽

Chain Complex ◽

Mitochondrial Respiratory Chain ◽

Respiratory Chain Complex ◽

Mitochondrial Respiratory Chain Complex ◽

Gene Coding ◽

Arabidopsis Mutant ◽

Mitochondrial Respiratory

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Bisbenzyltetrahydroisoquinolines, a New Class of Inhibitors of the Mitochondrial Respiratory Chain Complex I

Planta Medica ◽

10.1055/s-2004-818921 ◽

2004 ◽

Vol 70 (3) ◽

pp. 266-268 ◽

Cited By ~ 6

Keyword(s):

Respiratory Chain ◽

Complex I ◽

Chain Complex ◽

Mitochondrial Respiratory Chain ◽

Respiratory Chain Complex ◽

Mitochondrial Respiratory Chain Complex ◽

New Class ◽

Mitochondrial Respiratory

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Dysfunction of mitochondrial respiratory chain complex I in human failing myocardium is not due to disturbed mitochondrial gene expression

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(02)02600-1 ◽

2002 ◽

Vol 40 (12) ◽

pp. 2174-2181 ◽

Cited By ~ 95

Author(s):

Robert J Scheubel ◽

Mike Tostlebe ◽

Andreas Simm ◽

Susanne Rohrbach ◽

Roland Prondzinsky ◽

...

Keyword(s):

Gene Expression ◽

Respiratory Chain ◽

Complex I ◽

Mitochondrial Gene ◽

Chain Complex ◽

Mitochondrial Respiratory Chain ◽

Mitochondrial Gene Expression ◽

Respiratory Chain Complex ◽

Mitochondrial Respiratory Chain Complex ◽

Mitochondrial Respiratory

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Honokiol induces superoxide production by targeting mitochondrial respiratory chain complex I in Candida albicans

PLoS ONE ◽

10.1371/journal.pone.0184003 ◽

2017 ◽

Vol 12 (8) ◽

pp. e0184003 ◽

Cited By ~ 26

Author(s):

Lingmei Sun ◽

Kai Liao ◽

Dayong Wang

Keyword(s):

Candida Albicans ◽

Respiratory Chain ◽

Complex I ◽

Chain Complex ◽

Mitochondrial Respiratory Chain ◽

Superoxide Production ◽

Respiratory Chain Complex ◽

Mitochondrial Respiratory Chain Complex ◽

Mitochondrial Respiratory

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A constant and similar assembly defect of mitochondrial respiratory chain complex I allows rapid identification of NDUFS4 mutations in patients with Leigh syndrome

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease ◽

10.1016/j.bbadis.2012.01.013 ◽

2012 ◽

Vol 1822 (6) ◽

pp. 1062-1069 ◽

Cited By ~ 25

Author(s):

Z. Assouline ◽

M. Jambou ◽

M. Rio ◽

C. Bole-Feysot ◽

P. de Lonlay ◽

...

Keyword(s):

Respiratory Chain ◽

Complex I ◽

Chain Complex ◽

Leigh Syndrome ◽

Mitochondrial Respiratory Chain ◽

Rapid Identification ◽

Respiratory Chain Complex ◽

Mitochondrial Respiratory Chain Complex ◽

Assembly Defect ◽

Mitochondrial Respiratory

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Inhibition of Mitochondrial Respiratory Chain Complex I Induces Vascular Endothelial Cell Apoptosis and Release of Mitochondrial DNA

The FASEB Journal ◽

10.1096/fasebj.2019.33.1_supplement.677.9 ◽

2019 ◽

Vol 33 (S1) ◽

Author(s):

Maryam Riaz ◽

Spencer C. Cushen ◽

Nicole R. Phillips ◽

Styliani Goulopoulou

Keyword(s):

Mitochondrial Dna ◽

Endothelial Cell ◽

Complex I ◽

Vascular Endothelial Cell ◽

Chain Complex ◽

Mitochondrial Respiratory Chain ◽

Vascular Endothelial ◽

Respiratory Chain Complex ◽

Endothelial Cell Apoptosis ◽

Mitochondrial Respiratory Chain Complex

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Dysfunction of Mitochondrial Respiratory Chain Complex I in Neurological Disorders: Genetics and Pathogenetic Mechanisms

Advances in Experimental Medicine and Biology - Advances in Mitochondrial Medicine ◽

10.1007/978-94-007-2869-1_17 ◽

2011 ◽

pp. 371-384 ◽

Cited By ~ 9

Author(s):

Vittoria Petruzzella ◽

Anna Maria Sardanelli ◽

Salvatore Scacco ◽

Damiano Panelli ◽

Francesco Papa ◽

...

Keyword(s):

Respiratory Chain ◽

Neurological Disorders ◽

Complex I ◽

Chain Complex ◽

Mitochondrial Respiratory Chain ◽

Respiratory Chain Complex ◽

Mitochondrial Respiratory Chain Complex ◽

Pathogenetic Mechanisms ◽

Mitochondrial Respiratory

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