scholarly journals The self-association coiled-coil domain of PML is sufficient for the oncogenic conversion of the retinoic acid receptor (RAR) alpha

Leukemia ◽  
2011 ◽  
Vol 25 (5) ◽  
pp. 814-820 ◽  
Author(s):  
M Occhionorelli ◽  
F Santoro ◽  
I Pallavicini ◽  
A Gruszka ◽  
S Moretti ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Receptor ◽  
Coiled Coil ◽  
The Self ◽  
Acid Receptor ◽  
Coiled Coil Domain ◽  
Self Association

scholarly journals The Coiled-Coil Domain of the Adenovirus Type 5 Protein IX Is Dispensable for Capsid Incorporation and Thermostability

2005 ◽  
Vol 79 (5) ◽  
pp. 3206-3210 ◽  
Author(s):  
Jort Vellinga ◽  
Diana J. M. van den Wollenberg ◽  
Stephanie van der Heijdt ◽  
Martijn J. W. E. Rabelink ◽  
Rob C. Hoeben
Keyword(s):  
Amino Acids ◽  
Coiled Coil ◽  
Adenovirus Type ◽  
The Self ◽  
Viral Capsid ◽  
Rich Domain ◽  
Coiled Coil Domain ◽  
Self Association ◽  
Protein Ix ◽  
Adenovirus Type 5

ABSTRACT The 14.4-kDa hexon-associated protein IX (pIX) acts as a cement in the capsids of primate adenoviruses and confers a thermostable phenotype. Here we show that deletion of amino acids 100 to 114 of adenovirus type 5 pIX, which eliminates the conserved coiled-coil domain, impairs its capacity to self-associate. However, pIXΔ100-114 is efficiently incorporated into the viral capsid, and the resulting virions are thermostable. Deletion of the central alanine-rich domain, as in pIXΔ60-72, does not impair self-association, incorporation into the capsid, or the thermostable phenotype. These data demonstrate, first, that the self-association of pIX is dispensable for its incorporation into the capsid and generation of the thermostability phenotype and, second, that the increased thermostability results from pIX monomers binding to different hexon capsomers rather than capsid stabilization by pIX multimers.

Contribution of retinoic acid receptor signalling to adrenal cortex morphology and functional zonation through modulation of WNT/[beta]-catenin pathway

2017 ◽  
Author(s):  
Zein Rami El ◽  
Amanda J Rickard ◽  
Golib Dzib Jose Felipe ◽  
Benoit Samson-Couterie ◽  
Angelique Rocha ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Adrenal Cortex ◽  
Retinoic Acid Receptor ◽  
Beta Catenin ◽  
Acid Receptor ◽  
Receptor Signalling

scholarly journals Arg269 and Lys220 of retinoic acid receptor-beta are important for the binding of retinoic acid.

1994 ◽  
Vol 269 (30) ◽  
pp. 19516-19522
Author(s):  
N. Tairis ◽  
J.L. Gabriel ◽  
M. Gyda ◽  
K.J. Soprano ◽  
D.R. Soprano
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Receptor ◽  
Acid Receptor ◽  
Retinoic Acid Receptor Beta ◽  
Receptor Beta

scholarly journals Structural insights into the interaction of the intrinsically disordered co-activator TIF2 with retinoic acid receptor heterodimer (RXR/RAR)

2021 ◽  
pp. 166899
Author(s):  
Lucile Senicourt ◽  
Albane le Maire ◽  
Frédéric Allemand ◽  
JoÃo E. Carvalho ◽  
Laura Guee ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Receptor ◽  
Acid Receptor ◽  
Intrinsically Disordered ◽  
Structural Insights
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