scholarly journals Analysis of risk factors influencing outcome in children with myelodysplastic syndrome after unrelated cord blood transplantation

Leukemia ◽  
2010 ◽  
Vol 25 (3) ◽  
pp. 449-454 ◽  
Author(s):  
A B M Madureira ◽  
◽  
M Eapen ◽  
F Locatelli ◽  
P Teira ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myelodysplastic Syndrome ◽  
Cord Blood ◽  
Cord Blood Transplantation ◽  
Unrelated Cord Blood Transplantation ◽  
Blood Transplantation ◽  
Factors Influencing ◽  
Unrelated Cord Blood

Unrelated cord blood transplantation for adult patients with advanced myelodysplastic syndrome

Blood ◽  
2003 ◽  
Vol 101 (12) ◽  
pp. 4711-4713 ◽  
Author(s):  
Jun Ooi ◽  
Tohru Iseki ◽  
Satoshi Takahashi ◽  
Akira Tomonari ◽  
Koji Ishii ◽  
...  
Keyword(s):  
Myelodysplastic Syndrome ◽  
Cord Blood ◽  
Median Time ◽  
Cord Blood Transplantation ◽  
Chronic Gvhd ◽  
Disease Free Survival ◽  
Adult Patients ◽  
Unrelated Cord Blood Transplantation ◽  
Blood Transplantation ◽  
Unrelated Cord Blood

AbstractWe report the results of unrelated cord blood transplantation (CBT) for 13 adult patients with advanced myelodysplastic syndrome (MDS). The median age was 40 years, the median weight was 51 kg, and the median number of infused nucleated cells was 2.43 × 107/kg. Twelve patients had myeloid reconstitution, and the median time to more than 0.5 × 109/L (5 × 108/L) absolute neutrophil count was 22.5 days. A self-sustained platelet count more than 50 × 109/L was achieved in 11 patients at a median time of 49 days. Acute graft versus host disease (GVHD) occurred in 9 of 12 evaluable patients and chronic GVHD in 8 of 11 evaluable patients. Ten patients are alive and free of disease at between 171 and 1558 days after transplantation. The probability of disease-free survival at 2 years was 76.2%. These results suggest that adult advanced MDS patients without suitable related or unrelated bone marrow donors should be considered as candidates for CBT.

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