scholarly journals MEK inhibitors potentiate dexamethasone lethality in acute lymphoblastic leukemia cells through the pro-apoptotic molecule BIM

Leukemia ◽  
2009 ◽  
Vol 23 (10) ◽  
pp. 1744-1754 ◽  
Author(s):  
A A Rambal ◽  
Z L G Panaguiton ◽  
L Kramer ◽  
S Grant ◽  
H Harada
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Mek Inhibitors

scholarly journals BIM mediates synergistic killing of B-cell acute lymphoblastic leukemia cells by BCL-2 and MEK inhibitors

2016 ◽  
Vol 7 (4) ◽  
pp. e2177-e2177 ◽  
Author(s):  
K Korfi ◽  
M Smith ◽  
J Swan ◽  
T C P Somervaille ◽  
N Dhomen ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
B Cell ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Mek Inhibitors ◽  
Cell Acute Lymphoblastic Leukemia

scholarly journals Inhibition of Autophagy Enhances the Antitumor Effect of Thioridazine in Acute Lymphoblastic Leukemia Cells

Life ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 365
Author(s):  
Carina Colturato-Kido ◽  
Rayssa M. Lopes ◽  
Hyllana C. D. Medeiros ◽  
Claudia A. Costa ◽  
Laura F. L. Prado-Souza ◽  
...  
Keyword(s):  
Cell Death ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Clinical Problem ◽  
Jurkat Cells ◽  
Leukemia Cells ◽  
Peripheral Mononuclear Blood ◽  
Induced Apoptosis ◽  
Cure Rates

Acute lymphoblastic leukemia (ALL) is an aggressive malignant disorder of lymphoid progenitor cells that affects children and adults. Despite the high cure rates, drug resistance still remains a significant clinical problem, which stimulates the development of new therapeutic strategies and drugs to improve the disease outcome. Antipsychotic phenothiazines have emerged as potential candidates to be repositioned as antitumor drugs. It was previously shown that the anti-histaminic phenothiazine derivative promethazine induced autophagy-associated cell death in chronic myeloid leukemia cells, although autophagy can act as a “double-edged sword” contributing to cell survival or cell death. Here we evaluated the role of autophagy in thioridazine (TR)-induced cell death in the human ALL model. TR induced apoptosis in ALL Jurkat cells and it was not cytotoxic to normal peripheral mononuclear blood cells. TR promoted the activation of caspase-8 and -3, which was associated with increased NOXA/MCL-1 ratio and autophagy triggering. AMPK/PI3K/AKT/mTOR and MAPK/ERK pathways are involved in TR-induced cell death. The inhibition of the autophagic process enhanced the cytotoxicity of TR in Jurkat cells, highlighting autophagy as a targetable process for drug development purposes in ALL.

Effects of amsacrine in combination with other anticancer agents in human acute lymphoblastic leukemia cells in culture

1991 ◽  
Vol 15 (11) ◽  
pp. 1059-1066 ◽  
Author(s):  
Yasuhiko Kano ◽  
Shinobu Sakamoto ◽  
Tadashi Kasahara ◽  
Miyuki Akutsu ◽  
Yoshiharu Inoue ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Anticancer Agents ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Cells In Culture ◽  
Human Acute Lymphoblastic Leukemia

scholarly journals 3D/4D multiscale imaging in acute lymphoblastic leukemia cells-visualizing dynamics of cell death

2017 ◽  
Author(s):  
Sreelatha Sarangapani ◽  
Rosmin Elsa Mohan ◽  
Ajeetkumar Patil ◽  
Matthew J. Lang ◽  
Anand Asundi
Keyword(s):  
Cell Death ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Multiscale Imaging
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