Development and use of a single-animal whole-body system for inhalation exposure

Lab Animal ◽  
2008 ◽  
Vol 37 (1) ◽  
pp. 33-40 ◽  
Author(s):  
Brian A. Wong ◽  
Paul W. Ross ◽  
R. Arden James
Keyword(s):  
Inhalation Exposure ◽  
Whole Body ◽  
Body System ◽  
Single Animal

Lung toxicity and gene expression changes in response to whole-body inhalation exposure to cellulose nanocrystal in rats

2021 ◽  
Vol 33 (2) ◽  
pp. 66-80
Author(s):  
Pius Joseph ◽  
Christina M. Umbright ◽  
Jenny R. Roberts ◽  
Jared L. Cumpston ◽  
Marlene S. Orandle ◽  
...  
Keyword(s):  
Gene Expression ◽  
Inhalation Exposure ◽  
Lung Toxicity ◽  
Cellulose Nanocrystal ◽  
Whole Body ◽  
Whole Body Inhalation

In vivo high-resolution MR imaging of the skin in a whole-body system at 1.5 T.

Radiology ◽  
1990 ◽  
Vol 176 (2) ◽  
pp. 457-460 ◽  
Author(s):  
J Bittoun ◽  
H Saint-Jalmes ◽  
B G Querleux ◽  
L Darrasse ◽  
O Jolivet ◽  
...  
Keyword(s):  
High Resolution ◽  
Mr Imaging ◽  
Whole Body ◽  
Body System

Improvement of Aerosol Distribution in Whole-Body Inhalation Exposure Chambers

1989 ◽  
Vol 1 (2) ◽  
pp. 153-166 ◽  
Author(s):  
Yung-Sung Cheng ◽  
Edward B. Barr ◽  
Robert L. Carpenter ◽  
Janet M. Benson ◽  
Charles H. Hobbs
Keyword(s):  
Inhalation Exposure ◽  
Whole Body ◽  
Aerosol Distribution ◽  
Whole Body Inhalation

Improvement of the acquisition of a large amount of MR images on a conventional whole body system

1999 ◽  
Vol 17 (3) ◽  
pp. 471-474 ◽  
Author(s):  
Uwe Klose ◽  
Michael Erb ◽  
Dirk Wildgruber ◽  
Edgar Müller ◽  
Wolfgang Grodd
Keyword(s):  
Whole Body ◽  
Body System ◽  
Mr Images

scholarly journals Mathematical model for glucose regulation in the whole-body system

Islets ◽  
2012 ◽  
Vol 4 (2) ◽  
pp. 84-93 ◽  
Author(s):  
Hyuk Kang ◽  
Kyungreem Han ◽  
MooYoung Choi
Keyword(s):  
Mathematical Model ◽  
Whole Body ◽  
Glucose Regulation ◽  
Body System

Radiation Carcinogenesis in the Whole-Body System

1991 ◽  
Vol 126 (2) ◽  
pp. 157 ◽  
Author(s):  
R. J. M. Fry
Keyword(s):  
Whole Body ◽  
Body System ◽  
Radiation Carcinogenesis

Thirteen-week study of toxicity of fiber-like multi-walled carbon nanotubes with whole-body inhalation exposure in rats

2014 ◽  
Vol 9 (4) ◽  
pp. 413-422 ◽  
Author(s):  
Tatsuya Kasai ◽  
Yumi Umeda ◽  
Makoto Ohnishi ◽  
Hitomi Kondo ◽  
Tetsuya Takeuchi ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Inhalation Exposure ◽  
Whole Body ◽  
Multi Walled Carbon Nanotubes ◽  
Whole Body Inhalation ◽  
Walled Carbon Nanotubes

Acute Microinstillation Inhalation Exposure to Sarin Induces Changes in Respiratory Dynamics and Functions in Guinea Pigs

2009 ◽  
Vol 28 (5) ◽  
pp. 436-447 ◽  
Author(s):  
Michele L. Conti ◽  
Magnus M. Che ◽  
Megan Boylan ◽  
Alfred M. Sciuto ◽  
Richard K. Gordon ◽  
...  
Keyword(s):  
Guinea Pigs ◽  
Inhalation Exposure ◽  
Minute Volume ◽  
Whole Body ◽  
Inspiratory Time ◽  
Post Exposure ◽  
Peak Inspiratory Flow ◽  
Respiratory Dynamics ◽  
Dynamics And Function ◽  
And Function

This study investigates the toxic effects of sarin on respiratory dynamics following microinstillation inhalation exposure in guinea pigs. Animals are exposed to sarin for 4 minutes, and respiratory functions are monitored at 4 hours and 24 hours by whole-body barometric plethysmography. Data show significant changes in respiratory dynamics and function following sarin exposure. An increase in respiratory frequency is observed at 4 hours post exposure compared with saline controls. Tidal volume and minute volume are also increased in sarin-exposed animals 4 hours after exposure. Peak inspiratory flow increases, whereas peak expiratory flow increases at 4 hours and is erratic following sarin exposure. Animals exposed to sarin show a significant decrease in expiratory time and inspiratory time. End-inspiratory pause is unchanged whereas end-expiratory pause is slightly decreased 24 hours after sarin exposure. These results indicate that inhalation exposure to sarin alters respiratory dynamics and function at 4 hours, with return to normal levels at 24 hours post exposure.

Sign in / Sign up

Export Citation Format

Share Document