Approaches to animal research project evaluation in Europe after implementation of Directive 2010/63/EU

Lab Animal ◽  
2014 ◽  
Vol 44 (1) ◽  
pp. 23-31 ◽  
Author(s):  
Javier Guillén ◽  
Sally Robinson ◽  
Thierry Decelle ◽  
Cornelia Exner ◽  
Martje Fentener van Vlissingen
Keyword(s):  
Project Evaluation ◽  
Animal Research ◽  
Research Project

scholarly journals Research Project Evaluation—Learnings from the PATHWAYS Project Experience

2018 ◽  
Vol 15 (6) ◽  
pp. 1071 ◽  
Author(s):  
Aleksander Galas ◽  
Aleksandra Pilat ◽  
Matilde Leonardi ◽  
Beata Tobiasz-Adamczyk
Keyword(s):  
Project Evaluation ◽  
Research Project

scholarly journals Research project evaluation and selection: an evidential reasoning rule-based method for aggregating peer review information with reliabilities

2015 ◽  
Vol 105 (3) ◽  
pp. 1469-1490 ◽  
Author(s):  
Wei-dong Zhu ◽  
Fang Liu ◽  
Yu-wang Chen ◽  
Jian-bo Yang ◽  
Dong-ling Xu ◽  
...  
Keyword(s):  
Peer Review ◽  
Project Evaluation ◽  
Evidential Reasoning ◽  
Research Project ◽  
Rule Based

scholarly journals Internal consistency and compatibility of the 3Rs and 3Vs principles for project evaluation of animal research

2020 ◽  
pp. 002367722096858
Author(s):  
Matthias Eggel ◽  
Hanno Würbel
Keyword(s):  
Internal Consistency ◽  
Study Protocol ◽  
Project Evaluation ◽  
Animal Research ◽  
Evaluation Procedure ◽  
Scientific Validity ◽  
Guiding Principle ◽  
Trade Offs ◽  
Study Designs ◽  
Internal And External Validity

Using animals for research raises ethical concerns that are addressed in project evaluation by weighing expected harm to animals against expected benefit to society. A harm–benefit analysis (HBA) relies on two preconditions: (a) the study protocol is scientifically suitable and (b) the use of (sentient) animals and harm imposed on them are necessary for achieving the study’s aims. The 3Rs (Replace, Reduce and Refine) provide a guiding principle for evaluating whether the use of animals, their number and the harm imposed on them are necessary. A similar guiding principle for evaluating whether a study protocol is scientifically suitable has recently been proposed: the 3Vs principle referring to the three main aspects of scientific validity in animal research (construct, internal and external validity). Here, we analyse the internal consistency and compatibility of these two principles, address conflicts within and between the 3Rs and 3Vs principles and discuss their implications for project evaluation. We show that a few conflicts and trade-offs exist, but that these can be resolved either by appropriate study designs or by ethical deliberation in the HBA. In combination, the 3Vs, 3Rs and the HBA thus offer a coherent framework for a logically structured evaluation procedure to decide about the legitimacy of animal research projects.

scholarly journals Monitoring and project evaluation as a principle of following efficiency of adopted measures

2012 ◽  
Vol 49 (No. 3) ◽  
pp. 128-132
Author(s):  
M. Hrabánková
Keyword(s):  
Monitoring System ◽  
Project Evaluation ◽  
Main Task ◽  
Research Project ◽  
The Individual ◽  
The Eu

The contribution supplies an outline of indicators, through which benefits from projects will be followed, that are prepared for usage in the LFA areas. It will be necessary to use the monitoring system for realisation of measures suggested on the base of the research project. The main task is to follow the efficiency of adopted measures for the individual environment sections, to evaluate efficiency of subsidies and finances from the EU funds. From the hitherto results, it is obvious on which measures are the prepared projects oriented at and by what indicators it will be possible to evaluate outputs, results and impacts of realised projects. The prepared system will enable feedback on decisions regarding efficiency of the realised measures in the monitored areas.

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