Hippocampal long-term potentiation in adult mice after recovery from ketamine anesthesia

Lab Animal ◽  
2014 ◽  
Vol 43 (10) ◽  
pp. 353-357 ◽  
Author(s):  
Patrícia O. Ribeiro ◽  
Henrique B. Silva ◽  
Ângelo R. Tomé ◽  
Rodrigo A. Cunha ◽  
Luís M. Antunes
Keyword(s):  
Long Term Potentiation ◽  
Adult Mice ◽  
Term Potentiation ◽  
Ketamine Anesthesia

scholarly journals Compensatory network changes in the dentate gyrus restore long-term potentiation following ablation of neurogenesis in young-adult mice

2011 ◽  
Vol 108 (13) ◽  
pp. 5437-5442 ◽  
Author(s):  
B. H. Singer ◽  
A. E. Gamelli ◽  
C. L. Fuller ◽  
S. J. Temme ◽  
J. M. Parent ◽  
...  
Keyword(s):  
Young Adult ◽  
Dentate Gyrus ◽  
Long Term Potentiation ◽  
Adult Mice ◽  
Term Potentiation

scholarly journals Oligodendrocytic Na+-K+-Cl– co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yoshihiko Yamazaki ◽  
Yoshifumi Abe ◽  
Satoshi Fujii ◽  
Kenji F. Tanaka
Keyword(s):  
Mouse Brain ◽  
Adult Mouse ◽  
Long Term Potentiation ◽  
Adaptive Plasticity ◽  
Adult Mouse Brain ◽  
Adult Mice ◽  
Term Potentiation ◽  
The Central Nervous System ◽  
Juvenile Mouse

AbstractThe juvenile brain presents plasticity. Oligodendrocytes are the myelinating cells of the central nervous system and myelination can be adaptive. Plasticity decreases from juvenile to adulthood. The mechanisms involving oligodendrocytes underlying plasticity are unclear. Here, we show Na+-K+-Cl– co-transporter 1 (NKCC1), highly expressed in the juvenile mouse brain, regulates the oligodendrocyte activity from juvenile to adulthood in mice, as shown by optogenetic manipulation of oligodendrocytes. The reduced neuronal activity in adults was restored by Nkcc1 overexpression in oligodendrocytes. Moreover, in adult mice overexpressing Nkcc1, long-term potentiation and learning were facilitated compared to age-matched controls. These findings demonstrate that NKCC1 plays a regulatory role in the age-dependent activity of oligodendrocytes, furthermore inducing activation of NKCC1 in oligodendrocytes can restore neuronal plasticity in the adult mouse brain.

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