Better lab animal models for translational neuroscience research and CNS drug development

Lab Animal ◽  
2017 ◽  
Vol 46 (4) ◽  
pp. 91-92 ◽  
Author(s):  
Darya A Meshalkina ◽  
Cai Song ◽  
Allan V Kalueff
Keyword(s):  
Animal Models ◽  
Drug Development ◽  
Translational Neuroscience ◽  
Neuroscience Research

scholarly journals Methods Used and Application of the Mouse Grimace Scale in Biomedical Research 10 Years On: A Scoping Review

Animals ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 673
Author(s):  
Alexandra L. Whittaker ◽  
Yifan Liu ◽  
Timothy H. Barker
Keyword(s):  
Animal Models ◽  
Mouse Models ◽  
Biomedical Research ◽  
Scoping Review ◽  
Facial Features ◽  
Inclusion Criteria ◽  
Academic Literature ◽  
Research Fields ◽  
Neuroscience Research ◽  
Wide Range

The Mouse Grimace Scale (MGS) was developed 10 years ago as a method for assessing pain through the characterisation of changes in five facial features or action units. The strength of the technique is that it is proposed to be a measure of spontaneous or non-evoked pain. The time is opportune to map all of the research into the MGS, with a particular focus on the methods used and the technique’s utility across a range of mouse models. A comprehensive scoping review of the academic literature was performed. A total of 48 articles met our inclusion criteria and were included in this review. The MGS has been employed mainly in the evaluation of acute pain, particularly in the pain and neuroscience research fields. There has, however, been use of the technique in a wide range of fields, and based on limited study it does appear to have utility for pain assessment across a spectrum of animal models. Use of the method allows the detection of pain of a longer duration, up to a month post initial insult. There has been less use of the technique using real-time methods and this is an area in need of further research.

scholarly journals Correction: A standardised framework to identify optimal animal models for efficacy assessment in drug development

PLoS ONE ◽  
2019 ◽  
Vol 14 (7) ◽  
pp. e0220325 ◽  
Author(s):  
Guilherme S. Ferreira ◽  
Désirée H. Veening-Griffioen ◽  
Wouter P. C. Boon ◽  
Ellen H. M. Moors ◽  
Christine C. Gispen-de Wied ◽  
...  
Keyword(s):  
Animal Models ◽  
Drug Development ◽  
Efficacy Assessment

scholarly journals Inhibitory control and emotion dysregulation: A framework for research on anxiety

2019 ◽  
Vol 31 (3) ◽  
pp. 859-869 ◽  
Author(s):  
Elise M. Cardinale ◽  
Anni R. Subar ◽  
Melissa A. Brotman ◽  
Ellen Leibenluft ◽  
Katharina Kircanski ◽  
...  
Keyword(s):  
Emotion Dysregulation ◽  
Flanker Task ◽  
Emotional Dysregulation ◽  
Response To Treatment ◽  
Second Step ◽  
Signal Delay ◽  
Antisaccade Task ◽  
Translational Neuroscience ◽  
Pediatric Anxiety ◽  
Neuroscience Research

AbstractWhile emotional dysregulation is a broad construct, the current paper adopts a narrow approach to facilitate translational neuroscience research on pediatric anxiety. The paper first presents data on an adapted version of the antisaccade task and then integrates these data into a research framework. Data on an adapted version of the antisaccade task were collected in 57 youth, including 35 seeking treatment for an anxiety disorder. Associations were examined between performance on the antisaccade task and (a) age, (b) performance on other cognitive-control tasks (i.e., the stop-signal delay and flanker tasks), and (c) level of anxiety symptoms. Better performance on the antisaccade task occurred in older relative to younger subjects and correlated with better performance on the flanker task. Across the 57 youth, higher levels of anxiety correlated with shorter latency for correct antisaccades. These data can be placed within a three-step framework for translational neuroscience research. In the first step, a narrow index of emotion dysregulation is targeted. In the second step, this narrow index is linked to other correlated indicators of the same underlying narrow latent construct. In the third and final step, associations are examined with clinical outcomes and response to treatment.

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