scholarly journals Results from the Atherosclerosis Risk in Communities study suggest that low serum magnesium is associated with incident kidney disease

2015 ◽  
Vol 87 (4) ◽  
pp. 820-827 ◽  
Author(s):  
Adrienne Tin ◽  
Morgan E. Grams ◽  
Nisa M. Maruthur ◽  
Brad C. Astor ◽  
David Couper ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Serum Magnesium ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Low Serum

Abstract P011: Serum Magnesium and the Incidence of Coronary Heart Disease Over 20 Years of Follow-up: The Atherosclerosis Risk in Communities Study

Circulation ◽  
2016 ◽  
Vol 133 (suppl_1) ◽  
Author(s):  
Jeffrey R Misialek ◽  
Alvaro Alonso ◽  
Aaron R Folsom ◽  
Erin D Michos ◽  
Casey M Rebholz ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Serum Magnesium ◽  
Peripheral Blood Flow ◽  
Atherosclerosis Risk In Communities ◽  
Chd Risk ◽  
Increased Risk ◽  
Atherosclerosis Risk ◽  
Low Serum

Background: Low serum magnesium (Mg) may be linked to higher cardiovascular risk through impaired glucose levels, elevated blood pressure, chronic inflammation, impaired vasomotor tone or peripheral blood flow, and electrocardiogram abnormalities. Relatively few studies have examined the association of serum Mg and coronary heart disease (CHD). Hypothesis: Individuals with low serum Mg levels will have an increased risk for CHD. Methods: We studied 13,349 participants (75% white, 57% women, mean age 54) free of CHD at baseline from the Atherosclerosis Risk in Communities study. Serum Mg, assessed at baseline (1987-89) and a second visit (1990-92), was averaged. Incident CHD cases through 2012 were ascertained from hospital discharge codes and death certificates and adjudicated by physician review. Multivariate Cox proportional hazards regression was used to estimate hazard ratios and 95% confidence intervals. Interactions by age, race, and sex were tested. Results: Over a median follow-up time of 23.4 years, 1,606 incident CHD cases were identified. Low serum Mg was associated with higher CHD risk after adjustment for demographics and behaviors (Table, Model 2). Although the test for trend was significant, most of the excess risk was for the lowest Mg category. The association persisted after adjustment for potential mediators (Table, Mediation Model). There was no evidence of significant interactions between serum Mg and age, race, or sex. Conclusion: Low serum Mg was associated with higher CHD risk, which is consistent with the proposed mechanisms and prior studies that have suggested a relationship. Interventional primary prevention studies could be considered to evaluate whether raising low serum Mg levels might lower CHD risk.

scholarly journals Serum magnesium and the incidence of coronary artery disease over a median 27 years of follow-up in the Atherosclerosis Risk in Communities (ARIC) Study and a meta-analysis

2019 ◽  
Vol 111 (1) ◽  
pp. 52-60 ◽  
Author(s):  
Mary R Rooney ◽  
Alvaro Alonso ◽  
Aaron R Folsom ◽  
Erin D Michos ◽  
Casey M Rebholz ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Meta Analysis ◽  
Serum Magnesium ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Artery Disease ◽  
Aric Study ◽  
Cad Risk ◽  
Low Serum

ABSTRACT Background Low serum magnesium (Mg) concentrations have been associated with higher coronary artery disease (CAD) risk. A previous Atherosclerosis Risk in Communities (ARIC) Study article that evaluated the Mg–CAD association, based on 319 events occurring over 4–7 y, identified a sex-interaction whereby the inverse Mg–CAD association was much stronger among women than men. More than 1700 additional ARIC CAD events have since accrued. Objective We aimed to test our hypothesis that serum Mg is inversely and independently associated with long-term CAD risk in ARIC and in a meta-analysis with other prospective studies. Methods A total of 14,446 ARIC study participants (baseline mean ± SD age: 54 ± 6 y, 57% women, 27% African American) were followed for incident CAD through 2017. CAD events were defined by myocardial infarction or CAD mortality. Serum Mg was modeled as quintiles based on mean visit 1 (1987–1989) and visit 2 (1990–1992) concentrations. Cox regression models were used. We also conducted a random-effects meta-analysis incorporating these contemporary ARIC findings. Results Over a median follow-up of 27 y, 2131 incident CAD cases accrued. Overall, low serum Mg was associated with higher CAD risk after adjustment for demographics, lifestyle factors, and other CAD risk factors than was higher serum Mg (HR Q1 compared with Q5: 1.28; 95% CI: 1.11, 1.47; P-linear trend <0.001). The association was stronger among women (HR Q1 compared with Q5: 1.53; 95% CI: 1.22, 1.92) than men (HR: 1.11; 95% CI: 0.92, 1.34) (P-interaction = 0.05). In the meta-analysis including 5 studies, the pooled RR (95% CI) for CAD in the lowest compared with the highest circulating Mg category was 1.18 (1.06, 1.31) (I2 = 22%, P-heterogeneity = 0.27). Conclusions In this large community-based cohort and updated meta-analysis, low circulating Mg was associated with higher CAD risk than was higher Mg. Whether increasing Mg concentrations within healthy limits is a useful strategy for CAD prevention remains to be seen.

scholarly journals Lung Function and Incident Kidney Disease: The Atherosclerosis Risk in Communities (ARIC) Study

2017 ◽  
Vol 70 (5) ◽  
pp. 675-685 ◽  
Author(s):  
Keiichi Sumida ◽  
Lucia Kwak ◽  
Morgan E. Grams ◽  
Kunihiro Yamagata ◽  
Naresh M. Punjabi ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Lung Function ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Aric Study

scholarly journals Serum magnesium and risk of sudden cardiac death in the Atherosclerosis Risk in Communities (ARIC) Study

2010 ◽  
Vol 160 (3) ◽  
pp. 464-470 ◽  
Author(s):  
James M. Peacock ◽  
Tetsuya Ohira ◽  
Wendy Post ◽  
Nona Sotoodehnia ◽  
Wayne Rosamond ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Serum Magnesium ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Aric Study
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