scholarly journals Phosphorylation of ribosomal protein S6 mediates compensatory renal hypertrophy

2015 ◽  
Vol 87 (3) ◽  
pp. 543-556 ◽  
Author(s):  
Jinxian Xu ◽  
Jianchun Chen ◽  
Zheng Dong ◽  
Oded Meyuhas ◽  
Jian-Kang Chen
Keyword(s):  
Ribosomal Protein ◽  
Renal Hypertrophy ◽  
Ribosomal Protein S6 ◽  
Compensatory Renal Hypertrophy

Regulation of ribosome synthesis during compensatory renal hypertrophy in mice

1987 ◽  
Vol 253 (4) ◽  
pp. C506-C513 ◽  
Author(s):  
A. J. Ouellette ◽  
R. Moonka ◽  
A. D. Zelenetz ◽  
R. A. Malt
Keyword(s):  
Ribosomal Protein ◽  
Ribosomal Proteins ◽  
Rdna Transcription ◽  
Renal Hypertrophy ◽  
Renal Growth ◽  
Compensatory Renal Hypertrophy ◽  
Steady State Levels ◽  
Precursor Rna ◽  
Ribosomal Precursor

Ribosomal synthesis was studied at the transcriptional and translational levels to investigate the mechanisms of ribosome accretion during compensatory renal hypertrophy. As measured by in vitro transcriptional runoff comparisons 6-48 h after surgery, nuclei from the kidney remaining after contralateral nephrectomy show an increase of up to 150% in the rate of synthesis of ribosomal precursor RNA. The rate of rDNA transcription is 40-50% greater than control values as early as 6 h after nephrectomy; by 48 h, the rate returns to normal. In contrast to the stimulated transcription of rDNA and accretion of rRNA, the steady-state levels and the cytoplasmic distribution of ribosomal protein mRNAs S16 and L10 remain unchanged during induced renal growth. Thus coordinate production of adequate protein for increased assembly of ribosomes during induced renal growth appears to be accomplished by increasingly efficient translation of existing ribosomal protein mRNAs or by post-translational stabilization of ribosomal proteins. The rate of rDNA transcription may be regulated by accelerating the transcription of already functioning genes or, more likely, by recruiting transcription units that are transcriptionally inactive in the normal kidney.

scholarly journals Ethionine and the phosphorylation of ribosomal protein S6.

1977 ◽  
Vol 252 (17) ◽  
pp. 6217-6221
Author(s):  
M A Treloar ◽  
M E Treloar ◽  
R Kisilevsky
Keyword(s):  
Ribosomal Protein ◽  
Ribosomal Protein S6
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