scholarly journals For better or worse: a niche for Notch in parietal epithelial cell activation

2013 ◽  
Vol 83 (6) ◽  
pp. 988-990 ◽  
Author(s):  
Mariya T. Sweetwyne ◽  
Katalin Susztak
Keyword(s):  
Epithelial Cell ◽  
Cell Activation ◽  
Parietal Epithelial Cell

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

10.3791/60324 ◽  
2020 ◽  
Author(s):  
Jennifer Eymael ◽  
Laura Miesen ◽  
Fieke Mooren ◽  
Jitske Jansen ◽  
Jack Wetzels ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Activation ◽  
Ex Vivo ◽  
Parietal Epithelial Cell ◽  
Ex Vivo Assay

scholarly journals New Insights into Glomerular Parietal Epithelial Cell Activation and Its Signaling Pathways in Glomerular Diseases

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Hua Su ◽  
Shan Chen ◽  
Fang-Fang He ◽  
Yu-Mei Wang ◽  
Philip Bondzie ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Signaling Pathways ◽  
Membranous Nephropathy ◽  
Cell Activation ◽  
Crescentic Glomerulonephritis ◽  
Diabetic Glomerulopathy ◽  
Glomerular Diseases ◽  
The Past ◽  
Parietal Epithelial Cell ◽  
Parietal Epithelial Cells

The glomerular parietal epithelial cells (PECs) have aroused an increasing attention recently. The proliferation of PECs is the main feature of crescentic glomerulonephritis; besides that, in the past decade, PEC activation has been identified in several types of noninflammatory glomerulonephropathies, such as focal segmental glomerulosclerosis, diabetic glomerulopathy, and membranous nephropathy. The pathogenesis of PEC activation is poorly understood; however, a few studies delicately elucidate the potential mechanisms and signaling pathways implicated in these processes. In this review we will focus on the latest observations and concepts about PEC activation in glomerular diseases and the newest identified signaling pathways in PEC activation.

scholarly journals Nature and Mediators of Parietal Epithelial Cell Activation in Glomerulonephritides of Human and Rat

2013 ◽  
Vol 183 (6) ◽  
pp. 1769-1778 ◽  
Author(s):  
Paola Rizzo ◽  
Norberto Perico ◽  
Elena Gagliardini ◽  
Rubina Novelli ◽  
Malcolm R. Alison ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Activation ◽  
Parietal Epithelial Cell

scholarly journals Parietal Epithelial Cell Activation Marker in Early Recurrence of FSGS in the Transplant

2012 ◽  
Vol 7 (11) ◽  
pp. 1852-1858 ◽  
Author(s):  
Huma Fatima ◽  
Marcus J. Moeller ◽  
Bart Smeets ◽  
Hai-Chun Yang ◽  
Vivette D. D’Agati ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Activation ◽  
Early Recurrence ◽  
Activation Marker ◽  
Cell Activation Marker ◽  
Parietal Epithelial Cell

scholarly journals Endothelial Epas1 Deficiency Is Sufficient To Promote Parietal Epithelial Cell Activation and FSGS in Experimental Hypertension

2017 ◽  
Vol 28 (12) ◽  
pp. 3563-3578 ◽  
Author(s):  
Yosu Luque ◽  
Olivia Lenoir ◽  
Philippe Bonnin ◽  
Lise Hardy ◽  
Anna Chipont ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Activation ◽  
Experimental Hypertension ◽  
Parietal Epithelial Cell

scholarly journals Glomerular parietal epithelial cell activation induces collagen secretion and thickening of Bowman’s capsule in diabetes

2014 ◽  
Vol 95 (3) ◽  
pp. 273-282 ◽  
Author(s):  
Alexander Holderied ◽  
Simone Romoli ◽  
Jonathan Eberhard ◽  
Lukas A Konrad ◽  
Satish K Devarapu ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Activation ◽  
Collagen Secretion ◽  
Parietal Epithelial Cell ◽  
Bowman's Capsule

Pathogenic Mechanisms Underlying Idiopathic Pulmonary Fibrosis

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Benjamin J. Moss ◽  
Stefan W. Ryter ◽  
Ivan O. Rosas
Keyword(s):  
Epithelial Cell ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Cell Activation ◽  
Alveolar Epithelial Cell ◽  
Cell Types ◽  
Annual Review ◽  
Publication Date ◽  
Metabolic Dysfunction ◽  
Epithelial Repair

The pathogenesis of idiopathic pulmonary fibrosis (IPF) involves a complex interplay of cell types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in the context of predisposing factors (e.g., genetic, environmental, epigenetic, immunologic, and gerontologic), leading to metabolic dysfunction, senescence, aberrant epithelial cell activation, and dysregulated epithelial repair. The dysregulated epithelial cell interacts with mesenchymal, immune, and endothelial cells via multiple signaling mechanisms to trigger fibroblast and myofibroblast activation. Recent single-cell RNA sequencing studies of IPF lungs support the epithelial injury model. These studies have uncovered a novel type of AEC with characteristics of an aberrant basal cell, which may disrupt normal epithelial repair and propagate a profibrotic phenotype. Here, we review the pathogenesis of IPF in the context of novel bioinformatics tools as strategies to discover pathways of disease, cell-specific mechanisms, and cell-cell interactions that propagate the profibrotic niche. Expected final online publication date for the Annual Review of Pathology: Mechanisms of Disease, Volume 17 is January 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

scholarly journals Divergent effects of Nitric oxide on airway epithelial cell activation

2010 ◽  
Vol 43 (4) ◽  
pp. 467-473
Author(s):  
Tommaso Neri ◽  
Ilaria Conti ◽  
Chiara Cerri ◽  
Laura Tavanti ◽  
Pierluigi Paggiaro ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Epithelial Cell ◽  
Cell Activation ◽  
Airway Epithelial Cell ◽  
Airway Epithelial
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