scholarly journals Can we prevent donor-specific antibodies from developing after ABO-incompatible kidney transplantation?

2014 ◽  
Vol 85 (2) ◽  
pp. 245-247 ◽  
Author(s):  
Lionel Rostaing ◽  
Nassim Kamar
Keyword(s):  
Kidney Transplantation ◽  
Specific Antibodies ◽  
Donor Specific Antibodies

scholarly journals Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates

2017 ◽  
Vol 1 (24) ◽  
pp. 2115-2119 ◽  
Author(s):  
Jean Kwun ◽  
Christopher Burghuber ◽  
Miriam Manook ◽  
Brian Ezekian ◽  
Jaeberm Park ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Graft Survival ◽  
Nonhuman Primates ◽  
Proteasome Inhibition ◽  
Costimulation Blockade ◽  
Specific Antibodies ◽  
Key Points ◽  
Donor Specific Antibodies

Key Points Targeting both PCs and GC response reduces donor-specific antibodies and prolongs graft survival in sensitized NHP kidney transplantation.

scholarly journals Impact of low‐level pretransplant donor‐specific antibodies on outcomes after kidney transplantation

2021 ◽  
Author(s):  
Sandesh Parajuli ◽  
Natalie M. Bath ◽  
Luis Hidalgo ◽  
Glen Leverson ◽  
Neetika Garg ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Specific Antibodies ◽  
Low Level ◽  
Donor Specific Antibodies

scholarly journals Combined Liver-Kidney Transplantation With Preformed Anti–human Leukocyte Antigen Donor-Specific Antibodies

2020 ◽  
Vol 5 (12) ◽  
pp. 2202-2211
Author(s):  
Arnaud Del Bello ◽  
Olivier Thaunat ◽  
Moglie Le Quintrec ◽  
Oriol Bestard ◽  
Antoine Durrbach ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Specific Antibodies ◽  
Leukocyte Antigen ◽  
Donor Specific Antibodies

Donor-specific antibodies in kidney transplantation

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Neetika Garg ◽  
Sandesh Parajuli ◽  
Didier A. Mandelbrot ◽  
Arjang Djamali
Keyword(s):  
Kidney Transplantation ◽  
Specific Antibodies ◽  
Donor Specific Antibodies

scholarly journals Kidney transplantation with positive complement-dependent lymphocytotoxicity crossmatch with negative flow crossmatching and Luminexx donor-specific antibodies

Renal Failure ◽  
2013 ◽  
Vol 35 (7) ◽  
pp. 1027-1030 ◽  
Author(s):  
Vivek B. Kute ◽  
Aruna V. Vanikar ◽  
Manoj R. Gumber ◽  
Varsha B. Trivedi ◽  
Pankaj R. Shah ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Specific Antibodies ◽  
Donor Specific Antibodies

scholarly journals Clinical relevance of HLA donor-specific antibodies detected by single antigen assay in kidney transplantation

2011 ◽  
Vol 27 (3) ◽  
pp. 1231-1238 ◽  
Author(s):  
J. L. Caro-Oleas ◽  
M. F. Gonzalez-Escribano ◽  
F. M. Gonzalez-Roncero ◽  
M. J. Acevedo-Calado ◽  
V. Cabello-Chaves ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Clinical Relevance ◽  
Specific Antibodies ◽  
Antigen Assay ◽  
Single Antigen ◽  
Donor Specific Antibodies

scholarly journals Intensity of de novo DSA detected by Immucor Lifecodes assay and C3d fixing antibodies are not predictive of subclinical ABMR after Kidney Transplantation

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0249934
Author(s):  
Dominique Bertrand ◽  
Rangolie Kaveri ◽  
Charlotte Laurent ◽  
Philippe Gatault ◽  
Maïté Jauréguy ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Prognostic Value ◽  
De Novo ◽  
Added Value ◽  
Multicentric Study ◽  
Specific Antibodies ◽  
Antibody Mediated Rejection ◽  
Single Antigen ◽  
Donor Specific Antibodies ◽  
Allograft Loss

De novo donor-specific antibodies (dnDSA) are associated with antibody-mediated rejection (ABMR) and allograft loss. We tested Immucor* (IM) Luminex Single-antigen beads (LSAB) assay and C3d-fixing antibodies in the setting of dnDSA and subclinical (s) ABMR. This retrospective multicentric study included 123 patients biopsied because of the presence of subclinical de novo DSA detected by One Lamda* Labscreen (MFI > 1000). In 112 patients, sera of the day of the biopsy were available and tested in a central lab with IM Lifecodes LSAB and C3d fixing antibodies assays. In 16 patients (14.3%), no DSA was detected using Immucor test. In 96 patients, at least one DSA was determined with IM. Systematic biopsies showed active sABMR in 30 patients (31.2%), chronic active sABMR in 17 patients (17.7%) and no lesions of sABMR in 49 KT recipients (51%). Intensitity criteria (BCM, BCR and AD-BCR) of DSA were not statistically different between these 3 histological groups. The proportion of patients with C3d-fixing DSA was not statistically different between the 3 groups and did not offer any prognostic value regarding graft survival. Performing biopsy for dnDSA could not be guided by the intensity criteria of IM LSAB assay. C3d-fixing DSA do not offer added value.

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