scholarly journals Molecular fingerprinting of the podocyte reveals novel gene and protein regulatory networks

2013 ◽  
Vol 83 (6) ◽  
pp. 1052-1064 ◽  
Author(s):  
Melanie Boerries ◽  
Florian Grahammer ◽  
Sven Eiselein ◽  
Moritz Buck ◽  
Charlotte Meyer ◽  
...  
Keyword(s):  
Regulatory Networks ◽  
Molecular Fingerprinting ◽  
Novel Gene

scholarly journals Bacterial contribution to genesis of the novel germ line determinant oskar

2018 ◽  
Author(s):  
Leo Blondel ◽  
Tamsin E. M. Jones ◽  
Cassandra G. Extavour
Keyword(s):  
Regulatory Networks ◽  
De Novo ◽  
Germ Line ◽  
Cell Formation ◽  
Unknown Origin ◽  
Coding Region ◽  
Novel Genes ◽  
Novel Gene ◽  
Developmental Mechanisms ◽  
Gene Origin

AbstractNew cellular functions and developmental processes can evolve by modifying existing genes or creating novel genes. Novel genes can arise not only via duplication or mutation but also by acquiring foreign DNA, also called horizontal gene transfer (HGT). Here we show that HGT likely contributed to the creation of a novel gene indispensable for reproduction in some insects. Long considered a novel gene with unknown origin, oskar has evolved to fulfil a crucial role in insect germ cell formation. Our analysis of over 100 insect Oskar sequences suggests that Oskar arose de novo via fusion of eukaryotic and prokaryotic sequences. This work shows that highly unusual gene origin processes can give rise to novel genes that can facilitate evolution of novel developmental mechanisms.One Sentence SummaryOur research shows that gene origin processes often considered highly unusual, including HGT and de novo coding region evolution, can give rise to novel genes that can both participate in pre-existing gene regulatory networks, and also facilitate the evolution of novel developmental mechanisms.

Abstract PR06: Analysis of enhancer transcription reveals novel gene regulatory networks in breast cancer

2016 ◽  
Author(s):  
Hector L. Franco ◽  
Anusha Nagari ◽  
Yuanxin Xi ◽  
Wenqian Li ◽  
Dana Richardson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Regulatory Networks ◽  
Regulatory Networks ◽  
Novel Gene ◽  
Gene Regulatory

EMBJ08, a novel gene promoting cell proliferation

2010 ◽  
Vol 34 (8) ◽  
pp. S50-S50
Author(s):  
Jing Li ◽  
Dongxia Hao ◽  
Weiwei Deng ◽  
Na Li ◽  
Shai Guo ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Novel Gene

1650: Novel Gene Expression Markers in Renal Tumors Using Rt-PCR on Fixed Tissues Useful in Differentiating Histologic Subtypes

2004 ◽  
Vol 171 (4S) ◽  
pp. 436-436
Author(s):  
John A. Petros ◽  
Audry N. Schuetz ◽  
Andrew N. Young ◽  
Q. Yin Goen ◽  
So Dug Lim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Renal Tumors ◽  
Rt Pcr ◽  
Novel Gene ◽  
Histologic Subtypes
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