scholarly journals Blockade of PDGF receptor signaling reduces myofibroblast number and attenuates renal fibrosis

2011 ◽  
Vol 80 (11) ◽  
pp. 1119-1121 ◽  
Author(s):  
Valerie S. LeBleu ◽  
Raghu Kalluri
Keyword(s):  
Renal Fibrosis ◽  
Pdgf Receptor ◽  
Receptor Signaling

scholarly journals Large-Scale Phosphoproteomics Reveals Shp-2 Phosphatase-Dependent Regulators of Pdgf Receptor Signaling

Cell Reports ◽  
2018 ◽  
Vol 22 (10) ◽  
pp. 2784-2796 ◽  
Author(s):  
Tanveer S. Batth ◽  
Moreno Papetti ◽  
Anamarija Pfeiffer ◽  
Maxim A.X. Tollenaere ◽  
Chiara Francavilla ◽  
...  
Keyword(s):  
Large Scale ◽  
Pdgf Receptor ◽  
Receptor Signaling

scholarly journals STXBP4 Drives Tumor Growth and Is Associated with Poor Prognosis through PDGF Receptor Signaling in Lung Squamous Cell Carcinoma

2017 ◽  
Vol 23 (13) ◽  
pp. 3442-3452 ◽  
Author(s):  
Yukihiro Otaka ◽  
Susumu Rokudai ◽  
Kyoichi Kaira ◽  
Michiru Fujieda ◽  
Ikuko Horikoshi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Tumor Growth ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Lung Squamous Cell Carcinoma ◽  
Pdgf Receptor ◽  
Receptor Signaling

scholarly journals Platelet-Derived Growth Factor Receptors Direct Vascular Development Independent of Vascular Smooth Muscle Cell Function

2008 ◽  
Vol 28 (18) ◽  
pp. 5646-5657 ◽  
Author(s):  
Wendy J. French ◽  
Esther E. Creemers ◽  
Michelle D. Tallquist
Keyword(s):  
Smooth Muscle ◽  
Growth Factor ◽  
Blood Vessel ◽  
Vascular Smooth Muscle ◽  
Yolk Sac ◽  
Embryonic Lethality ◽  
Platelet Derived Growth Factor ◽  
Pdgf Receptor ◽  
Cardiovascular Development ◽  
Receptor Signaling

ABSTRACT Complete loss of platelet-derived growth factor (PDGF) receptor signaling results in embryonic lethality around embryonic day 9.5, but the cause of this lethality has not been identified. Because cardiovascular failure often results in embryonic lethality at this time point, we hypothesized that a failure in cardiovascular development could be the cause. To assess the combined role of PDGF receptor α (PDGFRα) and PDGFRβ, we generated embryos that lacked these receptors in cardiomyocytes and vascular smooth muscle cells (VSMC) using conditional gene ablation. Deletion of either PDGFRα or PDGFRβ caused no overt vascular defects, but loss of both receptors using an SM22α-Cre transgenic mouse line led to a disruption in yolk sac blood vessel development. The cell population responsible for this vascular defect was the yolk sac mesothelial cells, not the cardiomyocytes or the VSMC. Coincident with loss of PDGF receptor signaling, we found a reduction in collagen deposition and an increase in MMP-2 activity. Finally, in vitro allantois cultures demonstrated a requirement for PDGF signaling in vessel growth. Together, these data demonstrate that PDGF receptors cooperate in the yolk sac mesothelium to direct blood vessel maturation and suggest that these effects are independent of their role in VSMC development.

scholarly journals Toll-Like Receptor Signaling and SIGIRR in Renal Fibrosis upon Unilateral Ureteral Obstruction

PLoS ONE ◽  
2011 ◽  
Vol 6 (4) ◽  
pp. e19204 ◽  
Author(s):  
Veronika Skuginna ◽  
Maciej Lech ◽  
Ramanjaneyulu Allam ◽  
Mi Ryu ◽  
Sebastian Clauss ◽  
...  
Keyword(s):  
Ureteral Obstruction ◽  
Renal Fibrosis ◽  
Unilateral Ureteral Obstruction ◽  
Receptor Signaling ◽  
Toll Like Receptor

Dual inhibition of c‐abl and PDGF receptor signaling by dasatinib and nilotinib for the treatment of dermal fibrosis

2008 ◽  
Vol 22 (7) ◽  
pp. 2214-2222 ◽  
Author(s):  
Alfiya Akhmetshina ◽  
Clara Dees ◽  
Margarita Pileckyte ◽  
Britta Maurer ◽  
Roland Axmann ◽  
...  
Keyword(s):  
Pdgf Receptor ◽  
Receptor Signaling ◽  
Dermal Fibrosis ◽  
Dual Inhibition

scholarly journals Small-molecule control of insulin and PDGF receptor signaling and the role of membrane attachment

1998 ◽  
Vol 8 (1) ◽  
pp. 11-18 ◽  
Author(s):  
Jian-xin Yang ◽  
Karen Symes ◽  
Mark Mercola ◽  
Stuart L. Schreiber
Keyword(s):  
Small Molecule ◽  
Pdgf Receptor ◽  
Receptor Signaling ◽  
Membrane Attachment
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