scholarly journals A genome-wide association study for diabetic nephropathy genes in African Americans

2011 ◽  
Vol 79 (5) ◽  
pp. 563-572 ◽  
Author(s):  
Caitrin W. McDonough ◽  
Nicholette D. Palmer ◽  
Pamela J. Hicks ◽  
Bong H. Roh ◽  
S Sandy An ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
African Americans ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals A Genome-Wide Association Study of Hypertension and Blood Pressure in African Americans

PLoS Genetics ◽  
2009 ◽  
Vol 5 (7) ◽  
pp. e1000564 ◽  
Author(s):  
Adebowale Adeyemo ◽  
Norman Gerry ◽  
Guanjie Chen ◽  
Alan Herbert ◽  
Ayo Doumatey ◽  
...  
Keyword(s):  
Blood Pressure ◽  
African Americans ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals Novel colon cancer susceptibility variants identified from a genome‐wide association study in African Americans

2017 ◽  
Vol 140 (12) ◽  
pp. 2728-2733 ◽  
Author(s):  
Hansong Wang ◽  
Stephanie L. Schmit ◽  
Christopher A. Haiman ◽  
Temitope O. Keku ◽  
Ikuko Kato ◽  
...  
Keyword(s):  
Colon Cancer ◽  
African Americans ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Cancer Susceptibility ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals A Genome-Wide Association Study of Renal Cell Carcinoma among African Americans

2013 ◽  
Vol 23 (1) ◽  
pp. 209-214 ◽  
Author(s):  
Mark P. Purdue ◽  
Yuanqing Ye ◽  
Zhaoming Wang ◽  
Joanne S. Colt ◽  
Kendra L. Schwartz ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
African Americans ◽  
Association Study ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals A genome-wide association study of serum uric acid in African Americans

2011 ◽  
Vol 4 (1) ◽  
Author(s):  
Bashira A Charles ◽  
Daniel Shriner ◽  
Ayo Doumatey ◽  
Guanjie Chen ◽  
Jie Zhou ◽  
...  
Keyword(s):  
Uric Acid ◽  
African Americans ◽  
Association Study ◽  
Serum Uric Acid ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals Insights to the Genetics of Diabetic Nephropathy Through a Genome-Wide Association Study of the GoKinD Collection

2010 ◽  
Vol 30 (2) ◽  
pp. 126-140 ◽  
Author(s):  
Marcus G. Pezzolesi ◽  
Jan Skupien ◽  
Josyf C. Mychaleckyj ◽  
James H. Warram ◽  
Andrzej S. Krolewski
Keyword(s):  
Diabetic Nephropathy ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

Genome-Wide Association Study of Platelet Function in African Americans

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 1068-1068
Author(s):  
Rehan Qayyum ◽  
Lewis Becker ◽  
Diane Becker ◽  
Lisa Yanek ◽  
Suzanne M Leal ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
African Americans ◽  
Association Study ◽  
Platelet Function ◽  
Genome Wide Association Study ◽  
Conflicts Of Interest ◽  
Platelet Rich Plasma ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

Abstract Abstract 1068 Background: We have previously shown that platelet aggregation, an essential component of pathogenesis of acute coronary syndromes, has higher heritability in African Americans than Caucasians. However, a genome-wide association study of native platelet function in African Americans has not been reported. Methods: Platelet-rich plasma (PRP) was isolated from blood samples obtained from the discovery (GeneSTAR, N=835) and replication (Platelet Genes and Physiology Study, N=119) cohorts. Optical aggregation was used to measure maximal aggregation in PRP after samples were stimulated with arachidonic acid, collagen, ADP, or epinephrine. Genotyping was conducted with Illumina 1M arrays. For each cohort, age- and sex-adjusted linear mixed models were used to test for association between each SNP and each phenotype under an additive model. Results: Of the 117 SNPs that were significant (P< 5 × 10−8) in the discovery sample, 50 SNPs in 4 regions were also significant in the replication sample (Table). Among the replicated SNPs, a previously reported SNP in European Americans, rs12041331, in the PEAR1 gene was associated with ADP- and epinephrine-mediated aggregation. 47 SNPs in the 17q21.31 region, in one LD block, were associated with collagen-mediated aggregation. Conclusions: In this first GWAS of native agonist-mediated platelet aggregation in African Americans, we have discovered, and replicated in an independent sample, 4 regions that are associated with platelet aggregation. Several genes in the identified regions are expressed in platelets and further study of these genes may provide novel insights in platelet biology. Disclosures: No relevant conflicts of interest to declare.

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