scholarly journals Detergent-resistant globotriaosyl ceramide may define verotoxin/glomeruli-restricted hemolytic uremic syndrome pathology

2009 ◽  
Vol 75 (11) ◽  
pp. 1209-1216 ◽  
Author(s):  
Fahima Khan ◽  
François Proulx ◽  
Clifford A. Lingwood
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
Uremic Syndrome ◽  
Globotriaosyl Ceramide

Involvement of the fractalkine pathway in the pathogenesis of childhood hemolytic uremic syndrome

Blood ◽  
2006 ◽  
Vol 109 (6) ◽  
pp. 2438-2445 ◽  
Author(s):  
María Victoria Ramos ◽  
Gabriela C. Fernández ◽  
Natasha Patey ◽  
Pablo Schierloh ◽  
Ramón Exeni ◽  
...  
Keyword(s):  
Renal Failure ◽  
Endothelial Cells ◽  
Hemolytic Uremic Syndrome ◽  
Cell Damage ◽  
Mononuclear Leukocytes ◽  
Selective Depletion ◽  
Inflammatory Processes ◽  
Uremic Syndrome ◽  
Globotriaosyl Ceramide ◽  
Postdiarrheal Hemolytic Uremic Syndrome

Abstract Thrombotic microangiopathy and acute renal failure are cardinal features of postdiarrheal hemolytic uremic syndrome (HUS). These conditions are related to endothelial and epithelial cell damage induced by Shiga toxin (Stx) through the interaction with its globotriaosyl ceramide receptor. However, inflammatory processes contribute to the pathogenesis of HUS by sensitizing cells to Stx fractalkine (FKN), a CX3C transmembrane chemokine expressed on epithelial and endothelial cells upon activation, is involved in the selective migration and adhesion of specific leukocyte subsets to tissues. Here, we demonstrated a selective depletion of circulating mononuclear leukocytes expressing the receptor for FKN (CX3CR1) in patients with HUS. We found a unique phenotype in children with HUS distinct from that seen in healthy, uremic, or infected controls, in which monocytes lost CX3CR1, down-modulated CD62L, and increased CD16. In addition, the CD56dim natural killer (NK) subpopulation was decreased, leading to an altered peripheral CD56dim/CD56bright ratio from 10.0 to 4.5. It is noteworthy that a negative correlation existed between the percentage of circulating CX3CR1+ leukocytes and the severity of renal failure. Finally, CX3CR1+ leukocytes were observed in renal biopsies from patients with HUS. We suggest that the interaction of CX3CR1+ cells with FKN present on activated endothelial cells may contribute to renal injury in HUS.

Modern Trends in Demographics and Inpatient Healthcare Utilization for Hemolytic Uremic Syndrome in the U.S.A.

2014 ◽  
Vol 2 (2) ◽  
pp. 19
Author(s):  
H. Stella Shin ◽  
Brian Becknell ◽  
Patricia B. Reagan ◽  
John D. Mahan ◽  
David S. Hains
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
Healthcare Utilization ◽  
Uremic Syndrome

Early Volume Expansion Improves the Outcome of Shigatoxin-Associated Hemolytic Uremic Syndrome. Data from the North Italian HUS Network

PEDIATRICS ◽  
2016 ◽  
Vol 137 (Supplement 3) ◽  
pp. 299A-299A
Author(s):  
Gianluigi Ardissino ◽  
Francesca Tel ◽  
Ilaria Possenti ◽  
Sara Testa ◽  
Dario Consonni ◽  
...  
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
Volume Expansion ◽  
The North ◽  
Uremic Syndrome

Early Volume Expansion Improves the Outcome of Shigatoxin-Associated Hemolytic Uremic Syndrome. Data from the North Italian HUS Network

2017 ◽  
Author(s):  
Gianluigi Ardissino ◽  
Francesca Tel ◽  
Ilaria Possenti ◽  
Sara Testa ◽  
Dario Consonni ◽  
...  
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
Volume Expansion ◽  
The North ◽  
Uremic Syndrome
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