scholarly journals Potential restoration of HDL function with apolipoprotein A-I mimetic peptide in end-stage renal disease

2009 ◽  
Vol 76 (4) ◽  
pp. 359-361 ◽  
Author(s):  
George A. Kaysen
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Mimetic Peptide ◽  
Hdl Function ◽  
Apolipoprotein A ◽  
Stage Renal Disease ◽  
End Stage

Reviews and Original Articles Lipoprotein(A) and Apolipoprotein(A) Phenotypes in Patients with End-Stage Renal Disease

1997 ◽  
Vol 17 (3) ◽  
pp. 236-242 ◽  
Author(s):  
Soon Bae Kim ◽  
Won Seok Yang ◽  
Eun Suk Kang ◽  
Won Ki Min ◽  
Jung Sik Park
Keyword(s):  
Molecular Weight ◽  
Renal Disease ◽  
Serum Albumin ◽  
High Molecular Weight ◽  
End Stage Renal Disease ◽  
Lipoprotein A ◽  
Apolipoprotein A ◽  
Significant Difference ◽  
Stage Renal Disease ◽  
End Stage

Objective To evaluate the distribution pattern of apolipoprotein(a) [Apo(a)] phenotypes in Koreans and the effect of dialysis modality on serum lipoprotein(a) [Lp(a)] concentration according to apo(a) phenotype in patients with end-stage renal disease (ESRO). Design Cross-sectional study. Setting A university hospital. Participants: 153 normal controls, 99 hemodialysis (HO) patients and 82 continuous ambulatory peritoneal dialysis (CAPO) patients. Main Outcome Measures Fasting serum Lp(a), lipids, and apo(a) phenotypes were measured. Results The frequencies of the subjects with apo(a) phenotypes of high-molecular weight only, including S3, S4, or S5 or null type were 95.4% of control, 100% of HO patients, and 95.1% of CAPO patients. The frequent apo(a) phenotypes in Koreans consisted of S4, S4S5, S5, and S5S5 isoforms. Significant difference was found in serum Lp(a) concentration among controls and HO and CAPO patients [median (interquartile range): 0.05 g/L, (0.01 0.19); 0.19g/L, (0.10 0.35); 0.63g/L, (0.28 0.90), p< 0.001]. Lp(a) levels in CAPO patients were significantly higher than in HO patients for all four common apo(a) isoforms found in Korean subjects. CAPO patients had higher total and LOL cholesterol levels, and higher ApoB levels than H O patients. Significant differences were found in serum albumin levels between controls and HO and CAPO patients (44 ± 3 g/L, 40 ± 4 g/L, 32 ± 7 g/L, respectively, p < 0.05). There were significant inverse correlations between serum albumin and Lp(a) (r = -0.33, p < 0.01), total cholesterol (r = -0.31, p < 0.01), LOL (r = -0.39, p < 0.01) or ApoB (r = -0.35, p < 0.01) in ESRO patients. A significant positive correlation was found between serum albumin and ApoA1 (r = 0.24, p < 0.01). Conclusion These findings indicate that Koreans have mainly high -molecular weight apo(a) phenotypes and serum Lp(a) is elevated in CAPO patients compared to HO patients for common apo(a) phenotypes, which may contribute to the frequent cardiovascular mortality in CAPO patients.

OXIDATIVE STRESS AND HDL FUNCTION IN END STAGE RENAL DISEASE

Nephrology ◽  
2002 ◽  
Vol 7 (1) ◽  
pp. A125-A125
Author(s):  
K Dwyer ◽  
A Baker ◽  
G Kalogerakis ◽  
S Christov ◽  
H Buss ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Hdl Function ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Small Apolipoprotein(a) Size Predicts Mortality in End-Stage Renal Disease

Circulation ◽  
2002 ◽  
Vol 106 (22) ◽  
pp. 2812-2818 ◽  
Author(s):  
J. Craig Longenecker ◽  
Michael J. Klag ◽  
Santica M. Marcovina ◽  
Neil R. Powe ◽  
Nancy E. Fink ◽  
...  
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Apolipoprotein A ◽  
Stage Renal Disease ◽  
End Stage

Marked decrease of apolipoprotein A-V in both diabetic and nondiabetic patients with end-stage renal disease

Metabolism ◽  
2007 ◽  
Vol 56 (4) ◽  
pp. 462-463 ◽  
Author(s):  
Tsutomu Hirano ◽  
Toshiyuki Hayashi ◽  
Mitsuru Adachi ◽  
Takayasu Taira ◽  
Hiroaki Hattori
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Marked Decrease ◽  
Apolipoprotein A ◽  
Stage Renal Disease ◽  
End Stage
Sign in / Sign up

Export Citation Format

Share Document