scholarly journals Shiga toxin-associated hemolytic uremic syndrome and thrombotic thrombocytopenic purpura: distinct mechanisms of pathogenesis

2009 ◽  
Vol 75 ◽  
pp. S29-S32 ◽  
Author(s):  
Phillip I Tarr
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Shiga Toxin ◽  
Thrombocytopenic Purpura ◽  
Uremic Syndrome

Atypical hemolytic uremic syndrome: from diagnosis to treatment

2015 ◽  
Vol 53 (11) ◽  
Author(s):  
Massimo Franchini
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Shiga Toxin ◽  
Thrombotic Microangiopathy ◽  
Atypical Hemolytic Uremic Syndrome ◽  
Rare Condition ◽  
Organ Damage ◽  
Thrombocytopenic Purpura ◽  
Haemolytic Uremic Syndrome ◽  
Uremic Syndrome

AbstractThrombotic microangiopathy (TMA) is a relatively rare condition but a medical urgency requiring immediate intervention to avoid irreversible organ damage or death. Symptoms on presentation include microangiopathic haemolytic anaemia, thrombocytopenia and organ damage. The most frequent direct causes of TMA are thrombotic thrombocytopenic purpura (TTP) and haemolytic uremic syndrome (HUS). The most common form of HUS is related to Shiga toxin producing

scholarly journals Making the Correct Diagnosis in Thrombotic Microangiopathy: A Narrative Review

2021 ◽  
Vol 8 ◽  
pp. 205435812110087
Author(s):  
Philip A. McFarlane ◽  
Martin Bitzan ◽  
Catherine Broome ◽  
Dana Baran ◽  
Jocelyn Garland ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Hemolytic Uremic Syndrome ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Shiga Toxin ◽  
Thrombotic Microangiopathy ◽  
Definitive Treatment ◽  
Accurate Identification ◽  
Thrombocytopenic Purpura ◽  
Etiological Diagnosis ◽  
Uremic Syndrome

Purpose of review: Thrombotic microangiopathy (TMA) is suspected in patients presenting with thrombocytopenia and evidence of a microangiopathic hemolytic anemia. Patients with TMA can be critically ill, so rapid and accurate identification of the underlying etiology is essential. Due to better insights into pathophysiology and causes of TMA, we can now categorize TMAs as thrombotic thrombocytopenic purpura, postinfectious (mainly Shiga toxin-producing Escherichia coli–induced) hemolytic uremic syndrome (HUS), TMA associated with a coexisting condition, or atypical HUS (aHUS). We recognized an unmet need in the medical community to guide the timely and accurate identification of TMA, the selection of tests to clarify its etiology, and the sequence of steps to initiate treatment. Sources of information: Key published studies relevant to the identification, classification, and treatment of TMAs in children or adults. These studies were obtained through literature searches conducted with PubMed or based on the prior knowledge of the authors. Methods: This review is the result of a consultation process that reflects the consensus of experts from Canada, the United States, and the United Arab Emirates. The members represent individuals who are clinicians, researchers, and teachers in pediatric and adult medicine from the fields of hematology, nephrology, and laboratory medicine. Authors, through an iterative review process identified and synthesized information from relevant published studies. Key findings: Thrombotic thrombocytopenic purpura occurs in the setting of insufficient activity of the von Willebrand factor protease known as ADAMTS13. Shiga toxin-producing Escherichia coli–induced hemolytic uremic syndrome, also known as “typical” HUS, is caused by gastrointestinal infections with bacteria that produce Shiga toxin (initially called verocytotoxin). A variety of clinical conditions or drug exposures can trigger TMA. Finally, aHUS occurs in the setting of inherited or acquired abnormalities in the alternative complement pathway leading to dysregulated complement activation, often following a triggering event such as an infection. It is possible to break the process of etiological diagnosis of TMA into 2 distinct steps. The first covers the initial presentation and diagnostic workup, including the processes of identifying the presence of TMA, appropriate initial tests and referrals, and empiric treatments when appropriate. The second step involves confirming the etiological diagnosis and moving to definitive treatment. For many forms of TMA, the ultimate response to therapies and the outcome of the patient depends on the rapid and accurate identification of the presence of TMA and then a standardized approach to seeking the etiological diagnosis. We present a structured approach to identifying the presence of TMA and steps to identifying the etiology including standardized lab panels. We emphasize the importance of early consultation with appropriate specialists in hematology and nephrology, as well as identification of whether the patient requires plasma exchange. Clinicians should consider appropriate empiric therapies while following the steps we have recommended toward definitive etiologic diagnosis and management of the TMA. Limitations: The evidence base for our recommendations consists of small clinical studies, case reports, and case series. They are generally not controlled or randomized and do not lend themselves to a stricter guideline-based methodology or a Grading of Recommendations Assessment, Development and Evaluation (GRADE)-based approach.

scholarly journals Two novel ADAMTS13 gene mutations in thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome (TTP/HUS)

2004 ◽  
Vol 66 (3) ◽  
pp. 955-958 ◽  
Author(s):  
Christoph Licht ◽  
Ludwig Stapenhorst ◽  
Thorsten Simon ◽  
Ulrich Budde ◽  
Reinhard Schneppenheim ◽  
...  
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Gene Mutations ◽  
Thrombocytopenic Purpura ◽  
Uremic Syndrome

The Japanese experience with thrombotic thrombocytopenic purpura-hemolytic uremic syndrome

2004 ◽  
Vol 41 (1) ◽  
pp. 68-74 ◽  
Author(s):  
Masanori Matsumoto ◽  
Hideo Yagi ◽  
Hiromichi Ishizashi ◽  
Hideo Wada ◽  
Yoshihiro Fujimura
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Thrombocytopenic Purpura ◽  
Japanese Experience ◽  
Uremic Syndrome
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