scholarly journals Common genetic variants in the chromogranin A promoter alter autonomic activity and blood pressure

2008 ◽  
Vol 74 (1) ◽  
pp. 115-125 ◽  
Author(s):  
Y. Chen ◽  
F. Rao ◽  
J.L. Rodriguez-Flores ◽  
N.R. Mahapatra ◽  
M. Mahata ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Genetic Variants ◽  
Chromogranin A ◽  
Autonomic Activity ◽  
Common Genetic Variants

scholarly journals Common Genetic Variants in the Endothelial System Predict Blood Pressure Response to Sodium Intake: The GenSalt Study

2013 ◽  
Vol 26 (5) ◽  
pp. 643-656 ◽  
Author(s):  
M. D. Defago ◽  
D. Gu ◽  
J. E. Hixson ◽  
L. C. Shimmin ◽  
T. K. Rice ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Genetic Variants ◽  
Sodium Intake ◽  
Blood Pressure Response ◽  
Pressure Response ◽  
Common Genetic Variants

scholarly journals Identifying Common Genetic Variants in Blood Pressure Due to Polygenic Pleiotropy With Associated Phenotypes

Hypertension ◽  
2014 ◽  
Vol 63 (4) ◽  
pp. 819-826 ◽  
Author(s):  
Ole A. Andreassen ◽  
Linda K. McEvoy ◽  
Wesley K. Thompson ◽  
Yunpeng Wang ◽  
Sjur Reppe ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Genetic Variants ◽  
Common Genetic Variants

Abstract 17254: Adenosine A2A Receptor Polymorphisms and Response to Regadenoson

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Rolf P Kreutz ◽  
Ronald Mastouri ◽  
Rayan Saab ◽  
Santosh Philips ◽  
Todd Skaar
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Genetic Variants ◽  
Stress Testing ◽  
Multivariate Adjustment ◽  
Common Genetic Variants ◽  
A2a Receptor ◽  
Stress Score ◽  
Nuclear Stress Testing ◽  
Adenosine A2a

Introduction: Activation of adenosine A2A receptors induces coronary vasodilation and sympathetic activation. Regadenoson is an A2A agonist used in pharmacologic cardiac nuclear stress testing, and exhibits large variability in hemodynamic response and incidence of side effects. Common genetic variants of A2A have been associated with functional differences in neurological phenotypes. Hypothesis: We hypothesized that common polymorphisms of A2A may influence response to regadenoson during cardiac stress testing. Methods: We prospectively enrolled 268 patients undergoing resting regadenoson stress testing. Five common A2A receptor variants were analyzed by Taqman genotyping assay. SPECT technetium nuclear stress tests were performed and analyzed using the 17-segment model. Blood pressure and heart rate changes were recorded prospectively after administration of regadenoson. Results: Variants of A2A were associated with significant differences in heart rate (HR), peak systolic blood pressure (SBP), and summed stress score (Table). The association of rs2298383 (minor allele frequency (MAF)=0.49), rs5751876 (MAF=0.39), and rs3761422 (MAF=0.4) with heart rate and blood pressure at rest and peak remained significant after multivariate adjustment for demographics, race, and clinical variables. Similarly, carrier status of rs2298383, rs5751876, rs3761422, and rs2267076 (MAF=0.37) remained significantly associated with summed stress score (SSS) after multivariate adjustment. Conclusion: Common genetic variants of A2A may be associated with variability in heart rate and blood pressure response to regadenoson and extent of ischemia on nuclear myocardial perfusion imaging. Further studies are necessary to examine the influence of A2A receptor variants on diagnostic sensitivity of regadenoson nuclear stress testing.

Genetic Variation: Impact on Folate (and Choline) Bioefficacy

2010 ◽  
Vol 80 (45) ◽  
pp. 319-329 ◽  
Author(s):  
Allyson A. West ◽  
Marie A. Caudill
Keyword(s):  
Carbon Metabolism ◽  
Genetic Variants ◽  
Plasma Homocysteine ◽  
Water Soluble ◽  
Gene Interactions ◽  
Dietary Folate ◽  
Methyl Donors ◽  
Common Genetic Variants ◽  
One Carbon Metabolism ◽  
The Impact

Folate and choline are water-soluble micronutrients that serve as methyl donors in the conversion of homocysteine to methionine. Inadequacy of these nutrients can disturb one-carbon metabolism as evidenced by alterations in circulating folate and/or plasma homocysteine. Among common genetic variants that reside in genes regulating folate absorptive and metabolic processes, homozygosity for the MTHFR 677C > T variant has consistently been shown to have robust effects on status markers. This paper will review the impact of genetic variants in folate-metabolizing genes on folate and choline bioefficacy. Nutrient-gene and gene-gene interactions will be considered along with the need to account for these genetic variants when updating dietary folate and choline recommendations.

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