scholarly journals Dietary protein, urea nitrogen appearance and total nitrogen appearance in chronic renal failure and CAPD patients

1997 ◽  
Vol 52 (2) ◽  
pp. 486-494 ◽  
Author(s):  
Joel D. Kopple ◽  
Xiu-Lin Gao ◽  
David Peiyuan Qing
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Total Nitrogen ◽  
Dietary Protein ◽  
Urea Nitrogen ◽  
Urea Nitrogen Appearance

Origin of Glycosylated Hemoglobin Al in Chronic Renal Failure

1983 ◽  
Vol 6 (2) ◽  
pp. 77-82 ◽  
Author(s):  
S. De Marchi ◽  
E. Cecchin ◽  
C. Camurri ◽  
P. Quaia ◽  
A. Raimondi ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Blood Urea Nitrogen ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Urea Nitrogen ◽  
Plasma Bicarbonate ◽  
Arterial Blood ◽  
Blood Ph

In chronic renal failure both HbAI and HbAlc levels have been reported to be elevated. In order to investigate the causes of such increase we measured HbAI (cation-exchange chromatography), blood urea nitrogen, arterial blood pH, plasma bicarbonate, phosphatemia, serum iron and serum ferritin before dialysis in 60 uremic patients receiving long term hemodialysis. The increased levels of HbAI do not correlate with glucose intolerance, phosphatemia, blood urea nitrogen, time averaged concentration of urea, serum iron and serum ferritin. On the contrary the presence of a highly significant correlation between HbAI and arterial blood pH (p < 0.001) and between HbAI and plasma bicarbonate (p < 0.001) seems to emphasize a major role for acidosis in increasing the HbAI levels in uremic patients on long term hemodialysis.

The Estimation of Dietary Protein Intake in Chronic Renal Failure

1989 ◽  
Vol 4 (10) ◽  
pp. 877-882 ◽  
Author(s):  
G. A. Coles ◽  
J. H. Meadows ◽  
C. Bright ◽  
K. Tomlinson
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Dietary Protein ◽  
Protein Intake ◽  
Dietary Protein Intake

DIETARY PROTEIN RESTRICTION IN CHRONIC RENAL FAILURE

The Lancet ◽  
1985 ◽  
Vol 325 (8426) ◽  
pp. 465-466 ◽  
Author(s):  
H.A. Bock ◽  
F.P. Brunner ◽  
JohanB. Rosman ◽  
WimJ. Sluiter ◽  
AbJ.M. Donker
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Dietary Protein ◽  
Protein Restriction ◽  
Dietary Protein Restriction

Increased protein level of PEPT1 intestinal H+-peptide cotransporter upregulates absorption of glycylsarcosine and ceftibuten in 5/6 nephrectomized rats

2005 ◽  
Vol 288 (4) ◽  
pp. G664-G670 ◽  
Author(s):  
Yuriko Shimizu ◽  
Satohiro Masuda ◽  
Kumiko Nishihara ◽  
Lin Ji ◽  
Masahiro Okuda ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Dietary Protein ◽  
Peptide Transporter ◽  
Protein Digestion ◽  
Small Peptides ◽  
Progression Of Renal Failure ◽  
Progression Of Renal Disease ◽  
Drug Pharmacokinetics ◽  
Pept1 Mrna

In chronic renal failure (CRF), dietary protein is one of the factors that deteriorates residual renal functions. Numerous studies have indicated that the products of protein digestion are mainly absorbed as small peptides. However, how small peptides are absorbed in CRF remains poorly understood. H+-coupled peptide transporter (PEPT1/ SLC15A1) plays an important role in the absorption of small peptides and peptide-like drugs in the small intestine. Because dietary protein intake is one of the risk factors for renal failure, the alteration of intestinal PEPT1 might have implications in the progression of renal disease as well as the pharmacokinetics of peptide-like drugs. In this study, we examined the alteration of intestinal PEPT1 in 5/6 nephrectomized (5/6 NR) rats, extensively used as a model of chronic renal failure. Absorption of [14C]glycylsarcosine and ceftibuten was significantly increased in 5/6 NR rats compared with sham-operated rats, without a change in intestinal protease activity. Western blot analysis indicated that the amount of intestinal PEPT1 protein in 5/6 NR rats was increased mainly at the upper region. On the other hand, the amount of intestinal PEPT1 mRNA was not significantly different from that of sham-operated rats. These findings indicate that the increase in absorption of small peptides and peptide-like drugs, caused by the upregulation of intestinal PEPT1 protein, might contribute to the progression of renal failure as well as the alteration of drug pharmacokinetics.

scholarly journals Effects of dietary protein on renal function and lipid metabolism in five-sixths nephrectomized rats

2003 ◽  
Vol 89 (4) ◽  
pp. 491-497 ◽  
Author(s):  
Shu-Tzu Chen ◽  
Sheng-Jeng Peng ◽  
Jiun-Rong Chen
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Lipid Metabolism ◽  
Chronic Renal Failure ◽  
Renal Disease ◽  
Dietary Protein ◽  
Casein Diet ◽  
Experimental Animals ◽  
Rate Of Progression ◽  
Progression Of Renal Failure

The objective of the present experiment was to examine the effect of substituting different quantities of soyabean protein for casein on renal function and lipid metabolism in rats with chronic renal failure induced by a five-sixths nephrectomy. Experimental animals were subjected to a nephrectomy and fed either casein or soyabean protein (200 or 100 g/kg diet). The diets were isoenergetic with identical fat, Na, K and P contents. Rats ingesting 200 g casein/kg diet showed a significantly (P<0·05) accelerated course of chronic renal failure, while the soyabean-protein groups showed retarded progression of the experimentally induced renal disease and hypercholesterolaemic effects. Rats in the low-soyabean-protein diet (100 g/kg) also demonstrated increased serum albumin and decreased serum triacylglycerol, total cholesterol concentrations and blood urea-N; however, the low-casein diet significantly (P<0·05) increased serum triacylglycerol. Results of the present study show that the replacement of casein by soyabean protein was related to the rate of progression of renal failure and improvement in lipid profiles in serum of five-sixths nephrectomized rats.

scholarly journals Dietary protein restriction in chronic renal failure: nutritional efficacy, compliance, and progression of renal insufficiency.

1991 ◽  
Vol 2 (4) ◽  
pp. 823-831
Author(s):  
W E Mitch
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Chronic Renal Failure ◽  
Renal Insufficiency ◽  
Dietary Protein ◽  
Scientific Basis ◽  
Protein Restriction ◽  
Dietary Compliance ◽  
Dietary Protein Restriction ◽  
Low Protein

Two findings prompted investigators to examine the effects of dietary manipulation on progression of chronic renal failure: dietary protein restriction is an effective method of ameliorating uremic symptoms and the course of renal insufficiency in an individual patient is predictable. Results from studies of patients and animals with chronic renal failure suggested that a low-protein, phosphorus-restricted diet could slow the rate of loss of renal function. In evaluating these studies, three questions should be considered. First, is the diet nutritionally adequate? Second, has dietary compliance been monitored and achieved? Third, is there evidence that restricting the diet will change the rate of loss of renal function? The scientific basis for each of these questions is addressed in this review.

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