scholarly journals Accuracy of the diagnosis of hypertensive nephrosclerosis in African Americans: A report from the African American Study of Kidney Disease (AASK) Trial

1997 ◽  
Vol 51 (1) ◽  
pp. 244-252 ◽  
Author(s):  
Agnes Fogo ◽  
Julia A. Breyer ◽  
Michael C. Smith ◽  
William H. Cleveland ◽  
Lawrence Agodoa ◽  
...  
Keyword(s):  
African American ◽  
African Americans ◽  
Kidney Disease ◽  
African American Study ◽  
American Study ◽  
Hypertensive Nephrosclerosis

scholarly journals Factors associated with enrollment of African Americans into a clinical trial: Results from the African American study of kidney disease and hypertension

2008 ◽  
Vol 29 (6) ◽  
pp. 837-842 ◽  
Author(s):  
Crystal A. Gadegbeku ◽  
Phyllis Kreger Stillman ◽  
Mark D. Huffman ◽  
James S. Jackson ◽  
John W. Kusek ◽  
...  
Keyword(s):  
Clinical Trial ◽  
African American ◽  
African Americans ◽  
Kidney Disease ◽  
African American Study ◽  
American Study ◽  
Factors Associated ◽  
Clinical Trial Results

scholarly journals Evaluation of serum creatinine for estimating glomerular filtration rate in African Americans with hypertensive nephrosclerosis: results from the African-American Study of Kidney Disease and Hypertension (AASK) Pilot Study.

1997 ◽  
Vol 8 (2) ◽  
pp. 279-287 ◽  
Author(s):  
R D Toto ◽  
K A Kirk ◽  
J Coresh ◽  
C Jones ◽  
L Appel ◽  
...  
Keyword(s):  
African American ◽  
Pilot Study ◽  
African Americans ◽  
Kidney Disease ◽  
Serum Creatinine ◽  
Creatinine Clearance ◽  
African American Study ◽  
Coefficient Of Determination ◽  
American Study ◽  
New Equation

Measurement of GFR is considered the standard for estimating renal function. However, standardized accurate GFR methodology is expensive and cumbersome; therefore, estimates of GFR based on serum creatinine concentration have been employed. The purpose of the study presented here was to assess the accuracy and precision of using serum creatinine measurements to estimate GFR in the screen cohort of The African-American Study of Kidney Disease and Hypertension (AASK) Pilot Study. GFR was estimated by four methods: 100/serum creatinine, Cockcroft-Gault equation, creatinine clearance from 24-h urine collection, and a new regression equation derived from the pilot study data. These methods were compared with renal clearance of 125I-iothalamate GFR (GFR1) in 193 hypertensive (diastolic blood pressure > or = 95 mm Hg) African-American screen (142 men, 51 women). A second GFR (GFR2) was performed in 98 screen who were eligible (GFR1 25-70 mL/min per 1.73 m2) for the pilot study. Accuracy was assessed by the difference of 125I-iothalamate GFR-estimated GFR (delta GFR), and precision was estimated from the combined root mean squared error (CRMSE) and the coefficient of determination (r2). The results for accuracy (+/- SD) and precision were as follows: (1) 100/Scr, delta GFR = -0.76 +/- 16.5, CRMSE = 16.5, r2 = 0.69; (2) Cockcroft-Gault, delta GFR = 9.56 +/- 14.9, CRMSE = 17.7, r2 = 0.66; 3) 24-h creatinine clearance, delta GFR = 0.79 +/- 20.7, CRMSE = 20.7, r2 = 0.49; 4) New equation delta GFR = -0.08 +/- 12.8, CRMSE 12.7, r2 = 0.75. In comparison, a second GFR (GFR2, N = 98) had delta GFR = 1.36 +/- 8.48, CRMSE 8.6, r2 = 0.75. Estimates based on 100/SCr and the new equation were the most precise. It was concluded that GFR estimated by serum creatinine is superior to outpatient 24-h urine creatinine clearance in this population. Serum creatinine values can be used to provide a reasonably accurate estimate of GFR in hypertensive African Americans.

Recruitment experience in the African American Study of Kidney disease and hypertension (AASK) pilot study

1996 ◽  
Vol 17 (4) ◽  
pp. S17-S33 ◽  
Author(s):  
Paul K. Whelton ◽  
Jeannette Y. Lee ◽  
John W. Kusek ◽  
Jeanne Charleston ◽  
Jennifer DeBruge ◽  
...  
Keyword(s):  
African American ◽  
Pilot Study ◽  
Kidney Disease ◽  
African American Study ◽  
American Study
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