scholarly journals Angiotensin I converting enzyme gene polymorphism in non-insulin dependent diabetes mellitus

1996 ◽  
Vol 50 (2) ◽  
pp. 657-664 ◽  
Author(s):  
Hiroaki Yoshida ◽  
Satoru Kuriyama ◽  
Yoshihito Atsumi ◽  
Haruo Tomonari ◽  
Tetsuya Mitarai ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gene Polymorphism ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Converting Enzyme ◽  
Angiotensin I ◽  
Enzyme Gene ◽  
Angiotensin I Converting Enzyme ◽  
Insulin Dependent

scholarly journals Angiotensin I-converting enzyme gene polymorphisms: relationship to nephropathy in patients with non-insulin dependent diabetes mellitus.

1998 ◽  
Vol 9 (9) ◽  
pp. 1664-1669
Author(s):  
W Grzeszczak ◽  
M J Zychma ◽  
B Lacka ◽  
E Zukowska-Szczechowska
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Control Group ◽  
Converting Enzyme ◽  
Angiotensin I ◽  
Enzyme Gene ◽  
Angiotensin I Converting Enzyme ◽  
Insulin Dependent

Nephropathy is a frequent complication of long-term diabetes. Strong evidence exists that genetic predisposition plays a major role in the development of diabetic nephropathy. The role of the angiotensin I-converting enzyme gene (ACE) in the susceptibility to nephropathy in diabetes, especially in non-insulin dependent diabetes mellitus (NIDDM), remains unclear. This study examines the association of two ACE polymorphisms: a 287-bp insertion/deletion (I/D) in intron 16 and PstI (A/G substitution in intron 7; alleles P/M) with renal complications in 941 NIDDM patients. From this group, for further analysis 127 patients were selected with overt proteinuria or chronic renal failure, 335 patients with microalbuminuria, and a control group of 254 normoalbuminuric patients with a diabetes duration of at least 10 yr. No significant differences in the distribution of ACE I/D and PstI genotypes or allele frequencies were observed between the examined groups. The results of this study strongly suggest that there is no association between the ACE gene I/D and PstI polymorphisms and nephropathy in NIDDM.

A DR3-related DX? gene polymorphism strongly associates with insulin-dependent diabetes mellitus

1986 ◽  
Vol 23 (1) ◽  
pp. 47-51 ◽  
Author(s):  
G. A. Hitman ◽  
J. Sachs ◽  
P. Cassell ◽  
J. Awad ◽  
G. F. Bottazzo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gene Polymorphism ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent
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