scholarly journals Renal growth hormone—Insulin-like growth factor-I system in acute renal failure

1995 ◽  
Vol 47 (6) ◽  
pp. 1658-1668 ◽  
Author(s):  
Tanny Tsao ◽  
Jin Wang ◽  
Fernando C. Fervenza ◽  
Thanh H. Vu ◽  
Isabella H. Jin ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Renal Growth ◽  
Factor I ◽  
Growth Factor I

The Insulin-Like Growth Factor–I Axis in Acute Renal Failure

Renal Failure ◽  
1998 ◽  
Vol 20 (2) ◽  
pp. 343-348 ◽  
Author(s):  
Michael M. Friedlaender ◽  
Fernando C. Fervenza ◽  
Tanny Tsao ◽  
Fay Hsu ◽  
Ralph Rabkin
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

Insulin-like growth factor I administration in young rats with acute renal failure

2002 ◽  
Vol 17 (12) ◽  
pp. 1005-1012 ◽  
Author(s):  
Alberto Medina ◽  
Marta Fernández-Fuente ◽  
Eduardo Carbajo-Pérez ◽  
Fernando Santos ◽  
Benito Amil ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Young Rats ◽  
Growth Factor I

Rat models for clinical use of insulin-like growth factor I in acute renal failure

1994 ◽  
Vol 266 (6) ◽  
pp. F949-F956 ◽  
Author(s):  
S. B. Miller ◽  
D. R. Martin ◽  
J. Kissane ◽  
M. R. Hammerman
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Growth Factor ◽  
Therapeutic Agent ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Renal Histology ◽  
Igf I ◽  
Growth Factor I ◽  
Short Time

Insulin-like growth factor I (IGF-I) improves kidney function and histopathology, when given within a short time (0.5 or 5 h) after an ischemic renal insult in rats. To examine the effects of IGF-I at times that would be more applicable if it were to be used as a therapeutic agent for acute renal failure in humans, we administered IGF-I to rats 24 h after ischemic injury or prior to the induction of injury (pretreatment). In rats that received IGF-I 24 h postischemia, serum creatinine and blood urea nitrogen (BUN) values were significantly lower during the subsequent 6 days than in vehicle-treated rats, and incorporation of 5-bromo-2'-deoxyuridine into tubular cells of the regenerating cortex, measured 48 h postischemia, was enhanced. When examined 7 days postinjury, kidneys from rats that received IGF-I 24 h postischemia were improved in histopathological appearance compared with kidneys from vehicle-treated animals. Whereas creatinine and BUN values were elevated above baseline in both vehicle and IGF-I-pretreated groups, recovery of normal renal function was accelerated by pretreatment with IGF-I. In addition, although we could detect no differences in histopathology at 24 h postinjury, IGF-I pretreatment resulted in more normal renal histology at 7 days postischemic injury and reduced weight loss after injury. Our data show that IGF-I hastens recovery and accelerates regeneration or repair of damaged epithelia following acute renal failure in rats when administered either 24 h postinjury or prior to induction of acute renal failure.(ABSTRACT TRUNCATED AT 250 WORDS)

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