scholarly journals Tissue-specific modulation of Na, K-ATPase α-subunit gene expression in uremic rats

1994 ◽  
Vol 45 (3) ◽  
pp. 672-678 ◽  
Author(s):  
Pilar Bofill ◽  
I. Annelise Goecke ◽  
Silvia Bonilla ◽  
Miriam Alvo ◽  
Elisa T. Marusic
Keyword(s):  
Gene Expression ◽  
Subunit Gene ◽  
Α Subunit ◽  
Tissue Specific

Extracellular signal regulated protein kinases mediate H+-K+ATPase α-subunit gene expression

2001 ◽  
Vol 120 (5) ◽  
pp. A308-A308
Author(s):  
S KUSAYANAGI ◽  
Y TAKEUCHI ◽  
K MITAMURA ◽  
A TODISCO
Keyword(s):  
Gene Expression ◽  
Protein Kinases ◽  
Subunit Gene ◽  
Α Subunit ◽  
Extracellular Signal

Comparison between parr and smolt Atlantic salmon (Salmo salar) α subunit gene expression of Na+/K+ ATPase in gill tissue

1996 ◽  
Vol 15 (1) ◽  
pp. 29-39 ◽  
Author(s):  
Helena C. D'Cotta ◽  
Claudiane Gallais ◽  
Bénédicte Saulier ◽  
Patrick Prunet
Keyword(s):  
Gene Expression ◽  
Atlantic Salmon ◽  
Salmo Salar ◽  
Gill Tissue ◽  
Subunit Gene ◽  
Α Subunit ◽  
Atlantic Salmon Salmo Salar

INHIBIN GENE EXPRESSION IN THE HUMAN CORPUS LUTEUM

1987 ◽  
Vol 115 (3) ◽  
pp. R21-R23 ◽  
Author(s):  
S.R. Davis ◽  
Z. Krozowski ◽  
R.I. McLachlan ◽  
H.G. Burger
Keyword(s):  
Gene Expression ◽  
Corpus Luteum ◽  
Luteal Phase ◽  
Corpora Lutea ◽  
Subunit Gene ◽  
Nucleic Acid Probes ◽  
Α Subunit ◽  
Normal Human ◽  
Human Menstrual Cycle ◽  
Human Corpus Luteum

ABSTRACT We report inhibin α- and βA -subunit gene expression in the human corpus luteum and placenta using human α-subunit and bovine βA -subunit nucleic acid probes. In addition, we have demonstrated the presence of immunoreactive and bioactive inhibin in human corpora lutea. Our findings suggest that this tissue is a significant source of inhibin during the luteal phase of the normal human menstrual cycle.

Regulation of Na+,K+-ATPase α Subunit Gene Expression during Mouse Preimplantation Development

1994 ◽  
Vol 162 (1) ◽  
pp. 259-266 ◽  
Author(s):  
Daniel J. MacPhee ◽  
Kevin J. Barr ◽  
Paul A. De Sousa ◽  
Stanley D.L. Todd ◽  
Gerald M. Kidder
Keyword(s):  
Gene Expression ◽  
Preimplantation Development ◽  
Subunit Gene ◽  
Α Subunit

scholarly journals Estrogen Receptor α Signaling Pathways Differentially Regulate Gonadotropin Subunit Gene Expression and Serum Follicle-Stimulating Hormone in the Female Mouse

Endocrinology ◽  
2008 ◽  
Vol 149 (8) ◽  
pp. 4168-4176 ◽  
Author(s):  
C. Glidewell-Kenney ◽  
J. Weiss ◽  
L. A. Hurley ◽  
J. E. Levine ◽  
J. L. Jameson
Keyword(s):  
Gene Expression ◽  
Estrogen Receptor ◽  
Targeted Mutagenesis ◽  
Estrogen Signaling ◽  
Subunit Gene ◽  
Glycoprotein Hormone ◽  
Estrogen Regulation ◽  
Α Subunit ◽  
Ovariectomized Mice ◽  
Serum Lh

Estrogen, acting via estrogen receptor (ER)α, regulates serum gonadotropin levels and pituitary gonadotropin subunit expression. However, the cellular pathways mediating this regulation are unknown. ERα signals through classical estrogen response element (ERE)-dependent genomic as well as nonclassical ERE-independent genomic and nongenomic pathways. Using targeted mutagenesis in mice to disrupt ERα DNA binding activity, we previously demonstrated that ERE-independent signaling is sufficient to suppress serum LH levels. In this study, we examined the relative roles of ERE-dependent and -independent estrogen signaling in estrogen regulation of LH, FSH, prolactin, and activin/inhibin subunit gene expression, pituitary LH and FSH protein content, and serum FSH levels. ERE-independent signaling was not sufficient for estrogen to induce pituitary prolactin mRNA or suppress pituitary LHβ mRNA, LH content, or serum FSH in estrogen-treated ovariectomized mice. However, ERE-independent signaling was sufficient to reduce pituitary glycoprotein hormone α-subunit, FSHβ, and activin-βB mRNA expression. Together with previous serum LH results, these findings suggest ERE-independent ERα signaling suppresses serum LH via reduced secretion, not synthesis. Additionally, ERE-dependent and ERE-independent ERα pathways may distinctly regulate steps involved in the synthesis and secretion of FSH.

Control of TSHβ and α Subunit Gene Expression by Thyroid Hormone

1986 ◽  
Vol 70 (s13) ◽  
pp. 16P-16P
Author(s):  
J.A. Franklyn ◽  
D.F. Wood ◽  
T.C. Lynam ◽  
D.B. Ramsden ◽  
K. Docherty ◽  
...  
Keyword(s):  
Gene Expression ◽  
Thyroid Hormone ◽  
Subunit Gene ◽  
Α Subunit

scholarly journals GATA-binding proteins regulate the human gonadotropin alpha-subunit gene in the placenta and pituitary gland.

1994 ◽  
Vol 14 (8) ◽  
pp. 5592-5602 ◽  
Author(s):  
D J Steger ◽  
J H Hecht ◽  
P L Mellon
Keyword(s):  
Gene Expression ◽  
Binding Proteins ◽  
Alpha Subunit ◽  
Sequence Motif ◽  
Subunit Gene ◽  
Glycoprotein Hormone ◽  
Specific Expression ◽  
Tissue Specific ◽  
Response Elements ◽  
Tissue Specific Expression

The human glycoprotein hormone alpha-subunit gene is expressed in two quite dissimilar tissues, the placenta and anterior pituitary. Tissue-specific expression is determined by combinations of elements, some of which are common and others of which are specific to each tissue. In the placenta, a composite enhancer confers specific expression. It contains four protein-binding sites: two cyclic AMP (cAMP) response elements that bind CREB, a trophoblast-specific element that binds TSEB, and a sequence motif, AGATAA, that matches the consensus binding site for a family of transcription factors termed the GATA-binding proteins. In pituitary gonadotropes, the cAMP response elements remain important for expression, TSEB is absent, and elements further upstream participate in tissue-specific expression. Here we establish a regulatory role for the GATA element in both the placenta and pituitary by demonstrating that a mutation of this element decreases alpha-subunit gene expression 15-fold in JEG-3 human placental cells and 2.5-fold in alpha T3-1 mouse pituitary gonadotropes. In JEG-3 cells, human GATA-2 (hGATA-2) and hGATA-3 are highly expressed and both proteins bind to the alpha-subunit gene GATA element. In alpha T3-1 cells, the GATA motif is bound by mouse GATA-2 (mGATA-2) and an mGATA-4-related protein. Cotransfection of hGATA-2 or hGATA-3 into alpha T3-1 cells activates the alpha-subunit gene threefold. These studies establish a role for the GATA-binding proteins in placental and pituitary alpha-subunit gene expression, significantly expanding the known target genes of GATA-2, GATA-3, and perhaps GATA-4.

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