scholarly journals Thromboxane A2 receptor blockade improves renal function and histopathology in the post-obstructive kidney

1994 ◽  
Vol 45 (1) ◽  
pp. 185-192 ◽  
Author(s):  
Craig A. Rinder ◽  
Perry V. Halushka ◽  
Mary Ann Sens ◽  
David W. Ploth
Keyword(s):  
Renal Function ◽  
Thromboxane A2 ◽  
Receptor Blockade ◽  
Thromboxane A2 Receptor

Thromboxane A2 synthase inhibition and thromboxane A2 receptor blockade by 2-[(4-cyanophenyl)amino]-3-chloro-1,4-naphthalenedione (NQ-Y15) in rat platelets

1997 ◽  
Vol 54 (2) ◽  
pp. 259-268 ◽  
Author(s):  
Tong-Shin Chang ◽  
Hyun-Mee Kim ◽  
Ki-Seon Lee ◽  
Lee-Yong Khil ◽  
Woong-Chon Mar ◽  
...  
Keyword(s):  
Thromboxane A2 ◽  
Receptor Blockade ◽  
Thromboxane A2 Receptor ◽  
Rat Platelets

Redirection of prostaglandin endoperoxide synthesis exerts additive antiplatelet effects in the presence of thromboxane A2 receptor blockade

1992 ◽  
Vol 24 ◽  
pp. 89
Author(s):  
Paolo Golino ◽  
Giuseppe Ambrosio ◽  
Massimo Ragni ◽  
Enrico Russolillo ◽  
Immacolata Pascucci ◽  
...  
Keyword(s):  
Thromboxane A2 ◽  
Receptor Blockade ◽  
Thromboxane A2 Receptor ◽  
Prostaglandin Endoperoxide

scholarly journals Thromboxane receptor blockade attenuates chronic cyclosporine nephrotoxicity and improves survival in rats with renal isograft.

1992 ◽  
Vol 2 (9) ◽  
pp. 1398-1404
Author(s):  
N Perico ◽  
M Rossini ◽  
O Imberti ◽  
B Malanchini ◽  
R P Cornejo ◽  
...  
Keyword(s):  
Serum Creatinine ◽  
Thromboxane A2 ◽  
Receptor Blockade ◽  
Lewis Rat ◽  
Thromboxane A2 Receptor ◽  
Time Points ◽  
Thromboxane Receptor ◽  
Before And After ◽  
Cyclosporine Nephrotoxicity ◽  
Observation Period

The question of whether pharmacological inhibition of the thromboxane A2 activity prevents cyclosporine-induced chronic renal dysfunction in a Lewis rat model of renal isograft was addressed. Transplanted animals were given a daily oral dose of cyclosporine (20 mg/kg; N = 15), cyclosporine (20 mg/kg) and the thromboxane A2 receptor antagonist GR32191 (3 mg/kg twice daily, by gavage; N = 15), or the vehicle alone (N = 12). Treatments were started the day of kidney transplant, and animals were monitored for 1 year. Cyclosporine-treated animals developed renal insufficiency, as documented by serum creatinine levels of 0.49 +/- 0.09, 0.95 +/- 0.12, and 1.38 +/- 0.15 mg/dL before and after 6 and 12 months of observation, respectively. Cyclosporine and GR32191 used in combination partially but significantly prevented the deterioration of renal function (serum creatinine, basal, 0.52 +/- 0.06; month 6, 0.68 +/- 0.04; month 12, 0.93 +/- 0.10 mg/dL). At the end of the study, GFR, as insulin clearance, was significantly lower in rats given cyclosporine (0.28 +/- 0.09 mL/min/100 g) than in rats given cyclosporine plus GR32191 (0.45 +/- 0.05 mL/min/100 g) or than in vehicle-treated animals (0.56 +/- 0.07 mL/min/100 g). Similar results were obtained for the effective RPF, measured as p-aminohippurate clearance. At the same time points, comparable to whole-blood cyclosporine levels were found in rats receiving cyclosporine alone and in those given cyclosporine plus GR32191. More than 50% of the animals on cyclosporine alone died from uremia before the end of the observation period. By contrast, rats receiving cyclosporine in combination with GR32191 had a prolonged survival.(ABSTRACT TRUNCATED AT 250 WORDS)

Sign in / Sign up

Export Citation Format

Share Document