scholarly journals Intracellular calcium concentration and activation of the Na+/H+ exchanger in essential hypertension

1994 ◽  
Vol 45 (4) ◽  
pp. 1037-1043 ◽  
Author(s):  
Esteban Poch ◽  
Albert Botey ◽  
Joan Gaya ◽  
Alejandro Darnell ◽  
Francisca Rivera ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Intracellular Calcium ◽  
Calcium Concentration ◽  
Intracellular Calcium Concentration

Sodium/lithium countertransport and intracellular calcium concentration in patients with essential hypertension and coronary heart disease

2003 ◽  
Vol 104 (3) ◽  
pp. 323-327
Author(s):  
Sybille GRUSKA ◽  
Ingo JENDRAL ◽  
Rainer RETTIG ◽  
Günter KRAATZ
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Essential Hypertension ◽  
Intracellular Calcium ◽  
Calcium Concentration ◽  
Calcium Signalling ◽  
Intracellular Calcium Concentration ◽  
Diabetic Patients ◽  
Hypertensive Patients ◽  
Increased Risk

The present study was designed to test the hypothesis that enhanced intracellular calcium signalling and increased sodium/lithium countertransport (Na+/Li+ CT) activity may be associated with coronary heart disease (CHD) in non-diabetic patients with essential hypertension. Platelet-activating factor (PAF)-evoked rises in the intracellular calcium concentration ([Ca2+]i) were measured in Epstein–Barr-virus-immortalized lymphoblasts from 62 hypertensive patients with CHD and 34 patients without CHD. Na+/Li+ CT activity was assessed in erythrocytes from 80 hypertensive patients with CHD and 46 patients without CHD. Baseline values of unstimulated and PAF-stimulated [Ca2+]i were not significantly different between hypertensive subjects with (baseline, 126±5nmol/l; stimulated, 550±43nmol/l) and without (baseline, 125±5nmol/l; stimulated, 654±105nmol/l) CHD. Similarly, Na+/Li+ CT activity was not significantly different between the two groups (patients with CHD, 219±8µmol·l-1·h-1; patients without CHD, 234±10µmol·l-1·h-1). We conclude that intracellular signal transduction, as indicated by PAF-induced rises in [Ca2+]i and Na+/Li+ CT activity, is not associated with an increased risk of CHD in non-diabetic patients with essential hypertension.

β-Amyloid-induced increase in the resting intracellular calcium concentration gives support to tell Alzheimer lymphocytes from control ones

2002 ◽  
Vol 58 (2) ◽  
pp. 203-205 ◽  
Author(s):  
András Palotás ◽  
János Kálmán ◽  
Miklós Palotás ◽  
Anna Juhász ◽  
Zoltán Janka ◽  
...  
Keyword(s):  
Intracellular Calcium ◽  
Calcium Concentration ◽  
Intracellular Calcium Concentration ◽  
Β Amyloid
Sign in / Sign up

Export Citation Format

Share Document