scholarly journals Hyperplasia precedes increased glomerular filtration rate in rat remnant kidney

1990 ◽  
Vol 37 (2) ◽  
pp. 758-766 ◽  
Author(s):  
Carol A. Miskell ◽  
David P. Simpson
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Remnant Kidney

scholarly journals Remnant kidney metabolism in the dog.

1991 ◽  
Vol 2 (1) ◽  
pp. 70-76
Author(s):  
A Fine
Keyword(s):  
Glomerular Filtration Rate ◽  
Metabolic Acidosis ◽  
Oxygen Uptake ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Normal Kidney ◽  
Renal Metabolism ◽  
Energy Substrates ◽  
Chronic Metabolic Acidosis ◽  
Remnant Kidney

A marked increase in oxygen uptake (Qo2) per nephron has been described in the remnant kidney of the rat. However, it is not known which substrates support renal metabolism in remnant kidney nor is it known whether similar changes in Qo2 occur in other species. Remnant kidney in the dog was induced by ligation of 60 to 75% of the renal arterial branches on one side followed 1 to 2 wk later by contralateral nephrectomy. At 3 months marked hypertrophy of the remnant kidney was found and the glomerular filtration rate was 18 +/- 1.8 mL/min compared with 31 +/- 2 in a normal kidney (P less than 0.01). Qo2 was 689 +/- 60 mumol/min/100 mL glomerular filtration rate in the remnant kidney compared with 564 +/- 42 mumol/min/100 mL glomerular filtration rate in the normal kidney (P less than 0.01). Total renal ammoniagenesis per nephron increased to values found in chronic metabolic acidosis although serum (K+) and (HCO3-) were no different than in the normal dog. The oxidation of glutamine and lactate by remnant kidneys accounted for over 80% of Qo2, similar to that of normal kidneys. It is concluded that hypermetabolism per nephron occurs in the remnant kidney of the dog and that glutamine and lactate are the major energy substrates in remnant kidney. Furthermore, factors other than serum (K+) and (HCO3-) augment ammoniagenesis in this model. However, when these results are expressed per whole kidney or per gram of tissue, hypermetabolism does not occur in these remnant kidneys.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals Compensation Capacity of the Living-Related Donor’s Remnant Kidney and Recipient’s Transplanted Kidney

2021 ◽  
Vol 7 (4) ◽  
Author(s):  
Huang X ◽  
Ma B ◽  
Lin W ◽  
Shao K ◽  
An H ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Transplanted Kidney ◽  
Living Related ◽  
Remnant Kidney

Introduction: We try to explore the compensatory capacity of living-related donor’s remnant kidney and recipient’s transplanted kidney in terms of the glomerular filtration rate (GFR).

Mechanisms of Post-Obstructive Diuresis in the Solitary Hydronephrotic Kidney of the Rat

1975 ◽  
Vol 48 (3) ◽  
pp. 167-176
Author(s):  
D. R. Wilson
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Sodium Excretion ◽  
Filtration Rate ◽  
Urine Osmolality ◽  
Urine Flow ◽  
Control Group ◽  
Water Reabsorption ◽  
Hydronephrotic Kidney ◽  
Remnant Kidney

1. In order to clarify further the phenomenon of post-obstructive diuresis, clearance and micro-puncture experiments were done before and after relief of partial ureteral obstruction in rats with a solitary hydronephrotic kidney. 2. Glomerular filtration rate, urine flow and sodium excretion increased markedly, whereas surface nephron glomerular filtration rate increased only slightly and intratubular pressure, proximal and distal tubular water reabsorption did not change significantly. Decreased tubular reabsorption in deeper nephrons and collecting ducts appeared to be of major importance in the post-obstructive diuresis after relief of chronic obstruction. 3. In order to examine further the distinctive functional characteristics of the chronically hydronephrotic kidney, the results were compared with control rats having a solitary normal kidney or a solitary remnant kidney with an intact renal medulla. Urine flow rate and sodium excretion were higher and urine osmolality was lower (P < 0.01) in post-obstructive kidneys when compared with either control group. There were no differences in glomerular filtration rate or surface nephron function which could account for the greater diuresis and natriuresis from the hydronephrotic kidney, thus confirming the importance of an abnormality in deep nephron or medullary function in post-obstructive diuresis. 4. There was a greater diuresis in post-obstructive rats with a marked increase in blood urea concentration. Water reabsorption in the distal nephron was decreased in such animals, as well as in urea-loaded rats with a remnant kidney, indicating the probable mechanism by which urea diuresis potentiates the phenomenon of post-obstructive diuresis.

Late intervention in the remnant kidney model attenuates proteinuria but not glomerular filtration rate decline

Nephrology ◽  
2020 ◽  
Author(s):  
Matthew R. Veitch ◽  
Kerri Thai ◽  
Yanling Zhang ◽  
Jean‐Francois Desjardins ◽  
Golam Kabir ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Late Intervention ◽  
Glomerular Filtration Rate Decline ◽  
Remnant Kidney

Clinical Renal Function Testing by External Double Isotope Monitoring Technique

1971 ◽  
Vol 10 (01) ◽  
pp. 16-24
Author(s):  
J. Fog Pedersen ◽  
M. Fog Pedersen ◽  
Paul Madsen
Keyword(s):  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Plasma Flow ◽  
Filtration Rate ◽  
Renal Plasma Flow ◽  
Correlation Coefficients ◽  
Feedback System ◽  
Effective Renal Plasma Flow ◽  
Advantages And Disadvantages

SummaryAn accurate catheter-free technique for clinical determination simultaneouslyof glomerular filtration rate and effective renal plasma flow by means of radioisotopes has been developed. The renal function is estimated by the amount of radioisotopes necessary to maintain a constant concentration in the patient’s blood. The infusion pumps are steered by a feedback system, the pumps being automatically turned on when the radiation measured over the patient’s head falls below a certain preset level and turned off when this level is again readied. 131I-iodopyracet was used for the estimation of effective renal plasma flow and125I-iothalamate estimation of the glomerular filtration rate. These clearances were compared to the conventional bladder clearances and good correlation was found between these two clearance methods (correlation coefficients 0.97 and.90 respectively). The advantages and disadvantages of this new clearance technique are discussed.

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