scholarly journals Effect of vitamin D metabolites on calcitriol metabolism in experimental renal failure

1989 ◽  
Vol 36 (2) ◽  
pp. 234-239 ◽  
Author(s):  
Sanjeev Patel ◽  
Robert U. Simpson ◽  
Chen H. Hsu
Nephron ◽  
1977 ◽  
Vol 18 (1) ◽  
pp. 26-34 ◽  
Author(s):  
Steven E. Weisbrode ◽  
Charles C. Capen

Nephron ◽  
1985 ◽  
Vol 40 (3) ◽  
pp. 286-291 ◽  
Author(s):  
Shoshi Takamoto ◽  
Toshio Onishi ◽  
Shigeto Morimoto ◽  
Shunji Imanaka ◽  
Hiroyasu Tsuchiya ◽  
...  

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Pierre D'Amour ◽  
Louise Rousseau ◽  
Stephen Hornyak ◽  
Zan Yang ◽  
Tom Cantor

Rats(r) with secondary hyperparathyroidism were studied to define the relationship between vitamin D metabolites and rPTH levels measured by 3 different rat ELISAs. Controls and renal failure (RF) rats were on a normal diet, while 2 groups on a low-calcium (-Ca) or a vitamin D-deficient (-D) diet. RF was induced surgically. Mild RF rats had normal calcium and 25(OH)D but reduced 1,25(OH)2D levels (P<.001) with a 2.5-fold increased in rPTH (P<.001). Severe RF rats and those on a -Ca or -D diet had reduced calcium (P<.01) and 25(OH)D levels (P<.05), with rPTH increased by 2 (-Ca diet;P<.05), 4 (-D diet;P<.001), and 20-folds (RF;P<.001) while 1,25(OH)2D was high (-Ca diet:P<.001) or low (-D diet, RF:P<.001). 25(OH)D and 1,25(OH)2D were positively and negatively related on the -Ca and -D diets, respectively. rPTH molecular forms behaved as expected in RF and on -Ca diet, but not on -D diet with more C-rPTH fragments when less were expected. This may be related to the short-time course of this study compared to prior studies.


1994 ◽  
Vol 45 (2) ◽  
pp. 509-514 ◽  
Author(s):  
Sanjeevkumar R. Patel ◽  
Hui Qiong Ke ◽  
Chen H. Hsu

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