scholarly journals Focal segmental glomerulosclerosis in children with idiopathic nephrotic syndrome. A report of the Southwest Pediatric Nephrology Study Group1

1985 ◽  
Vol 27 (2) ◽  
pp. 442-449 ◽  
Author(s):  
R.J. Hogg
Keyword(s):  
Nephrotic Syndrome ◽  
Focal Segmental Glomerulosclerosis ◽  
Idiopathic Nephrotic Syndrome ◽  
Pediatric Nephrology ◽  
Segmental Glomerulosclerosis

scholarly journals The role of cationic channels of the potential TRPC receptor in the pathogenesis of idiopathic nephrotic syndrome in children

2021 ◽  
Vol 66 (5) ◽  
pp. 67-74
Author(s):  
S. L. Morozov ◽  
V. V. Dlin
Keyword(s):  
Nephrotic Syndrome ◽  
Focal Segmental Glomerulosclerosis ◽  
Idiopathic Nephrotic Syndrome ◽  
Pediatric Nephrology ◽  
Urgent Problem ◽  
Steady Decrease ◽  
Segmental Glomerulosclerosis ◽  
Cationic Channels ◽  
Morphological Picture

Idiopathic nephrotic syndrome is the most common glomerulopathy in children, with a prevalence of approximately 16 per 100,000 of child population worldwide. Any chronic glomerular disease has the same type of development mechanism. Regardless of the damaging factor, after the death of a significant part of the nephrons, there occurs a steady decrease in the glomerular filtration rate, while morphologically we most often determine focal segmental glomerulosclerosis. Studying the causes of focal segmental glomerulosclerosis is an urgent problem in pediatric nephrology. Recently, there has been discussed the role of the cation channels of the potential receptor TRPC of podocytes in the development of proteinuria and focal segmental glomerulosclerosis. The article provides data on the role of TRPC receptors in the pathogenesis of focal segmental glomerulosclerosis. The authors present their our own data demonstrating gene expression of the cationic channels family of the potential receptor TRPC1, TRPC3, TRPC4, TRPC5 and TRPC6 in children with idiopathic nephrotic syndrome, depending on the morphological picture of the disease and sensitivity to steroid therapy.

Idiopathic Nephrotic Syndrome Associated with Focal Segmental Glomerulosclerosis

1982 ◽  
pp. 23-30 ◽  
Author(s):  
K. Schärer ◽  
R. Waldherr ◽  
D. E. Müller-Wiefel ◽  
F. Manz ◽  
V. Lenhard ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Focal Segmental Glomerulosclerosis ◽  
Idiopathic Nephrotic Syndrome ◽  
Segmental Glomerulosclerosis

scholarly journals Renal Biopsy: Use of Biomarkers as a Tool for the Diagnosis of Focal Segmental Glomerulosclerosis

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Crislaine Aparecida da Silva ◽  
Mariana Molinar Mauad Cintra ◽  
Eliângela de Castro Côbo ◽  
Marcos Vinícius da Silva ◽  
Fabiano Bichuette Custódio ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Renal Biopsy ◽  
Focal Segmental Glomerulosclerosis ◽  
Idiopathic Nephrotic Syndrome ◽  
Biological Molecules ◽  
Podocyte Injury ◽  
Segmental Glomerulosclerosis ◽  
Morphological Diagnosis ◽  
Potential Use

Focal segmental glomerulosclerosis (FSGS) is a glomerulopathy associated with nephrotic syndrome and podocyte injury. FSGS occurs both in children and adults and it is considered the main idiopathic nephrotic syndrome nowadays. It is extremely difficult to establish a morphological diagnosis, since some biopsies lack a considerable quantifiable number of sclerotic glomeruli, given their focal aspect and the fact that FSGS occurs in less than half of the glomeruli. Therefore, many biological molecules have been evaluated as potential markers that would enhance the diagnosis of FSGS. Some of these molecules and receptors are associated with the pathogenesis of FSGS and have potential use in diagnosis.

Sign in / Sign up

Export Citation Format

Share Document