scholarly journals Aluminum localization in bone from hemodialyzed patients: Relationship to matrix mineralization

1981 ◽  
Vol 20 (3) ◽  
pp. 375-385 ◽  
Author(s):  
Giulia Cournot-Witmer ◽  
Johanna Zingraff ◽  
Jean Jacques Plachot ◽  
Françoise Escaig ◽  
Roger Lefèvre ◽  
...  
Keyword(s):  
Matrix Mineralization ◽  
Aluminum Localization

Tranexamic acid promotes matrix mineralization in osteoblasts and inhibits osteoclastogenesis in vitro.

2020 ◽  
Author(s):  
J Keller ◽  
J Appelt ◽  
K Tseneva ◽  
D Jahn ◽  
S Jiang ◽  
...  
Keyword(s):  
Tranexamic Acid ◽  
Matrix Mineralization

Long bone fragility in NF1 is due to deficiency of architecture, micro-structure and matrix mineralization

2013 ◽  
Author(s):  
Jirko Kuhnisch ◽  
Jong Seto ◽  
Claudia Lange ◽  
Susanne Schrof ◽  
Sabine Stumpp ◽  
...  
Keyword(s):  
Bone Fragility ◽  
Long Bone ◽  
Micro Structure ◽  
Matrix Mineralization

Rescue diet restores bone matrix mineralization in mice with a non-functioning vitamin D receptor

2019 ◽  
Author(s):  
Barbara Misof ◽  
Stephane Blouin ◽  
Markus Hartmann ◽  
Jochen Hofstaetter ◽  
Klaus Klaushofer ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Bone Matrix ◽  
Matrix Mineralization ◽  
Bone Matrix Mineralization

Vitamin D Control of Osteoblast Function and Bone Extracellular Matrix Mineralization

2001 ◽  
Vol 11 (1-3) ◽  
pp. 28 ◽  
Author(s):  
J. P. T. M. van Leeuwen ◽  
M. van Driel ◽  
G. J. C. M. van den Bemd ◽  
H. A. P. Pols
Keyword(s):  
Vitamin D ◽  
Extracellular Matrix ◽  
Matrix Mineralization ◽  
Osteoblast Function

scholarly journals Head and neck osteosarcoma: CT and MR imaging features

2020 ◽  
Vol 49 (2) ◽  
pp. 20190202
Author(s):  
Zhendong Luo ◽  
Weiguo Chen ◽  
Xinping Shen ◽  
Genggeng Qin ◽  
Jianxiang Yuan ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Head And Neck ◽  
Giant Cell ◽  
High Signal ◽  
Imaging Features ◽  
Matrix Mineralization ◽  
Imaging Characteristics ◽  
Mri Features ◽  
Signal Intensities ◽  
Ct And Mri

Objective: This study aims to assess the CT and MRI features of head and neck osteosarcoma (HNO). Methods: 37 HNOs were identified, and the following imaging characteristics were reviewed on CT and MRI. Results: A total of 37 patients(age 41.5 ± 15.0 years old; 16 males, 21 females) were included in the study. Tumours occurred in the maxilla (16, 43.2%), mandible (8, 21.6%), skull base (6, 16.2%), calvarium (5, 13.5%), paranasal sinuses (1, 2.7%) and cervical soft tissue (1, 2.7%). 16 patients received radiotherapy for nasopharyngeal carcinoma. Three patients (8.1%) developed osteosarcomas related to a primary bone disease. 16 of the (43.2%) tumours demonstrated lytic density on CT scans, followed by 13 (35.1%) showing mixed density and 7 (18.9%) with sclerotic density. Matrix mineralization was present in 32 (86.5%). 3 out of 24 (12.5%) tumours showed lamellar periosteal reactions, 21 out of 24 (87.5%) showed spiculated periosteal reactions. 12 tumours showed low signal intensities on T1WI, with 16 having heterogeneous signal intensities. 10 tumours showed high signal intensities on T2WI, and 18 showed heterogeneous signal intensities. With contrast-enhanced images, 3 tumours showed homogeneous enhancement (2 osteoblastic and 1 giant cell-rich), 18 tumours showed heterogeneous enhancement (13 osteoblastic, 4 fibroblastic and 1 giant cell-rich), and 7 tumours showed peripheral enhancement (6 chondroblastic and 1 osteoblastic). These tumours were characterized by soft tissue masses with a diameter of 5.6 ± 1.8 cm. Conclusions: HNO is a rare condition and is commonly associated with previous radiation exposure. This study provides age, sex distribution, location, CT and MRI features of HNO.

scholarly journals Activation of nuclear factor-kappa B by TNF promotes nucleus pulposus mineralization through inhibition of ANKH and ENPP1

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Agata K. Krzyzanowska ◽  
Robert J. Frawley ◽  
Sheela Damle ◽  
Tony Chen ◽  
Miguel Otero ◽  
...  
Keyword(s):  
Nucleus Pulposus ◽  
Inflammatory Cytokines ◽  
Intervertebral Disc Degeneration ◽  
Inflammatory Cytokine ◽  
Mineral Content ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Matrix Mineralization ◽  
Phenotypic Changes ◽  
Cellular Alterations

AbstractSpontaneous mineralization of the nucleus pulposus (NP) has been observed in cases of intervertebral disc degeneration (IDD). Inflammatory cytokines have been implicated in mineralization of multiple tissues through their modulation of expression of factors that enable or inhibit mineralization, including TNAP, ANKH or ENPP1. This study examines the underlying factors leading to NP mineralization, focusing on the contribution of the inflammatory cytokine, TNF, to this pathologic event. We show that human and bovine primary NP cells express high levels of ANKH and ENPP1, and low or undetectable levels of TNAP. Bovine NPs transduced to express TNAP were capable of matrix mineralization, which was further enhanced by ANKH knockdown. TNF treatment or overexpression promoted a greater increase in mineralization of TNAP-expressing cells by downregulating the expression of ANKH and ENPP1 via NF-κB activation. The increased mineralization was accompanied by phenotypic changes that resemble chondrocyte hypertrophy, including increased RUNX2 and COL10A1 mRNA; mirroring the cellular alterations typical of samples from IDD patients. Disc organ explants injected with TNAP/TNF- or TNAP/shANKH-overexpressing cells showed increased mineral content inside the NP. Together, our results confirm interactions between TNF and downstream regulators of matrix mineralization in NP cells, providing evidence to suggest their participation in NP calcification during IDD.

scholarly journals Effective Actions of Ion Release from Mesoporous Bioactive Glass and Macrophage Mediators on the Differentiation of Osteoprogenitor and Endothelial Progenitor Cells

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1152
Author(s):  
Alberto Polo-Montalvo ◽  
Laura Casarrubios ◽  
María Concepción Serrano ◽  
Adrián Sanvicente ◽  
María José Feito ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Mesoporous Structure ◽  
Ion Release ◽  
Endothelial Progenitor ◽  
Matrix Mineralization ◽  
Intracellular Content

Due to their specific mesoporous structure and large surface area, mesoporous bioactive glasses (MBGs) possess both drug-delivery ability and effective ionic release to promote bone regeneration by stimulating osteogenesis and angiogenesis. Macrophages secrete mediators that can affect both processes, depending on their phenotype. In this work, the action of ion release from MBG-75S, with a molar composition of 75SiO2-20CaO-5P2O5, on osteogenesis and angiogenesis and the modulatory role of macrophages have been assessed in vitro with MC3T3-E1 pre-osteoblasts and endothelial progenitor cells (EPCs) in monoculture and in coculture with RAW 264.7 macrophages. Ca2+, phosphorous, and silicon ions released from MBG-75S were measured in the culture medium during both differentiation processes. Alkaline phosphatase activity and matrix mineralization were quantified as the key markers of osteogenic differentiation in MC3T3-E1 cells. The expression of CD31, CD34, VEGFR2, eNOS, and vWF was evaluated to characterize the EPC differentiation into mature endothelial cells. Other cellular parameters analyzed included the cell size and complexity, intracellular calcium, and intracellular content of the reactive oxygen species. The results obtained indicate that the ions released by MBG-75S promote osteogenesis and angiogenesis in vitro, evidencing a macrophage inhibitory role in these processes and demonstrating the high potential of MBG-75S for the preparation of implants for bone regeneration.

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