scholarly journals In situ formation of subepithelial glomerular immune complexes in passive serum sickness

1980 ◽  
Vol 17 (5) ◽  
pp. 631-637 ◽  
Author(s):  
Gertjan Fleuren ◽  
Joris Grond ◽  
Philip J. Hoedemaeker
Keyword(s):  
Immune Complexes ◽  
Serum Sickness ◽  
In Situ Formation

scholarly journals Covalent attachment of soluble proteins by nonenzymatically glycosylated collagen. Role in the in situ formation of immune complexes.

1983 ◽  
Vol 158 (5) ◽  
pp. 1739-1744 ◽  
Author(s):  
M Brownlee ◽  
S Pongor ◽  
A Cerami
Keyword(s):  
Immune Complexes ◽  
Structural Proteins ◽  
Covalent Attachment ◽  
Nonenzymatic Glycosylation ◽  
Collagen Binding ◽  
Free Antibody ◽  
In Situ Formation ◽  
Immune Complex Formation

The chronic tissue damage associated with long-term diabetes mellitus may arise in part from in situ immune complex formation by accumulated immunoglobulins and/or antigens bound to long-lived structural proteins that have undergone excessive nonenzymatic glycosylation. In this report, we have tested this hypothesis using nonenzymatically glycosylated collagen. Binding of both albumin and IgG averaged four times the amount bound to unmodified collagen. Both albumin and IgG (anti-BSA) bound to nonenzymatically glycosylated collagen retained their ability to form immune complexes in situ with free antibody and antigen.

In situ Formation of Subepithelial Immune Complexes in the Rabbit Glomerulus: Requirement of a Cationic Antigen

Nephron ◽  
1984 ◽  
Vol 36 (4) ◽  
pp. 257-264 ◽  
Author(s):  
Harry J. Ward ◽  
Arthur H. Cohen ◽  
Wayne A. Border
Keyword(s):  
Immune Complexes ◽  
In Situ Formation ◽  
Cationic Antigen

scholarly journals INTERSTITIAL IMMUNE COMPLEX THYROIDITIS IN MICE

1974 ◽  
Vol 140 (6) ◽  
pp. 1439-1456 ◽  
Author(s):  
James A. Clagett ◽  
Curtis B. Wilson ◽  
William O. Weigle
Keyword(s):  
Basement Membrane ◽  
Immune Complex ◽  
Immune Complexes ◽  
Basal Area ◽  
Dense Deposits ◽  
Thyroid Glands ◽  
Intimate Association ◽  
In Situ Formation ◽  
Neutrophil Infiltrate

Mice immunized with soluble heterologous thyroglobulins developed autoantibody that cross-reacted with autologous thyroglobulin. There was a direct correlation between the temporal appearance and quantity of serum autoantibody and the presumed in situ formation of immune complexes in the interstitium of the thyroid glands. Immediately after the formation of interstitial immune complexes containing antibody of the IgG complement-fixing type, the thyroids were invaded by a transient but intense neutrophil infiltrate which within 1 wk was replaced by chronic mononuclear elements. By the combination of fluorescence microscopy and autoradiography, thyroglobulin was demonstrated to be one, if not the sole, antigen in the interstitial immune complexes. The interstitial immune complexes were granular to lumpy in appearance and formed at the basal area of the follicular cells in intimate association with the follicular basement membrane. Electron microscopy revealed electron dense deposits, presumably immune complexes, between the follicular basement membrane and the plasma membrane. The presumed in situ formation of immune complexes in this model is similar to that which occurs in the Arthus reaction and is a different mechanism of immune complex injury than that caused by tissue deposition of circulating immune complexes as occurs in serum sickness.

scholarly journals Formation of compact systems of super-Earths via dynamical instabilities and giant impacts

2019 ◽  
Vol 491 (4) ◽  
pp. 5595-5620 ◽  
Author(s):  
Sanson T S Poon ◽  
Richard P Nelson ◽  
Seth A Jacobson ◽  
Alessandro Morbidelli
Keyword(s):  
Initial Conditions ◽  
Post Processing ◽  
Significant Modification ◽  
Kepler Mission ◽  
Giant Impacts ◽  
Low Mass ◽  
In Situ Formation ◽  
Dynamical Instabilities ◽  
Gaseous Envelopes

ABSTRACT The NASA’s Kepler mission discovered ∼700 planets in multiplanet systems containing three or more transiting bodies, many of which are super-Earths and mini-Neptunes in compact configurations. Using N-body simulations, we examine the in situ, final stage assembly of multiplanet systems via the collisional accretion of protoplanets. Our initial conditions are constructed using a subset of the Kepler five-planet systems as templates. Two different prescriptions for treating planetary collisions are adopted. The simulations address numerous questions: Do the results depend on the accretion prescription?; do the resulting systems resemble the Kepler systems, and do they reproduce the observed distribution of planetary multiplicities when synthetically observed?; do collisions lead to significant modification of protoplanet compositions, or to stripping of gaseous envelopes?; do the eccentricity distributions agree with those inferred for the Kepler planets? We find that the accretion prescription is unimportant in determining the outcomes. The final planetary systems look broadly similar to the Kepler templates adopted, but the observed distributions of planetary multiplicities or eccentricities are not reproduced, because scattering does not excite the systems sufficiently. In addition, we find that ∼1 per cent of our final systems contain a co-orbital planet pair in horseshoe or tadpole orbits. Post-processing the collision outcomes suggests that they would not significantly change the ice fractions of initially ice-rich protoplanets, but significant stripping of gaseous envelopes appears likely. Hence, it may be difficult to reconcile the observation that many low-mass Kepler planets have H/He envelopes with an in situ formation scenario that involves giant impacts after dispersal of the gas disc.

scholarly journals Method for determining the thermal conductivity of in situ formation rock using drilling cuttings

AIP Advances ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 065015
Author(s):  
Fu Yi ◽  
Xupeng Qi ◽  
Xuexin Zheng ◽  
Huize Yu ◽  
Wenming Bai ◽  
...  
Keyword(s):  
Thermal Conductivity ◽  
In Situ Formation
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