scholarly journals The association of congenital heart disease with necrotizing enterocolitis in preterm infants: a birth cohort study

2015 ◽  
Vol 35 (11) ◽  
pp. 949-953 ◽  
Author(s):  
C Motta ◽  
W Scott ◽  
L Mahony ◽  
J Koch ◽  
M Wyckoff ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Cohort Study ◽  
Heart Disease ◽  
Birth Cohort ◽  
Preterm Infants ◽  
Necrotizing Enterocolitis ◽  
Congenital Heart ◽  
Birth Cohort Study

The Diagnostic Yield of Prenatal Genetic Technologies in Congenital Heart Disease: A Prospective Cohort Study

2021 ◽  
pp. 1-8
Author(s):  
Fionnuala Mone ◽  
Bethany K. Stott ◽  
Susan Hamilton ◽  
Anna N. Seale ◽  
Elizabeth Quinlan-Jones ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Cohort Study ◽  
Heart Disease ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Congenital Heart ◽  
Diagnostic Yield ◽  
Genetic Diagnosis ◽  
Uncertain Significance ◽  
Conotruncal Anomalies

<b><i>Introduction:</i></b> The objective was to evaluate: (i) the proportion of prenatally diagnosed congenital heart disease (CHD) associated with an abnormal quantitative fluorescence-PCR (QF-PCR), chromosome microarray (CMA), and exome sequencing (ES) result; and (ii) the diagnostic yield of these technologies based on CHD category and presence of extra-cardiac anomalies (ECAs). <b><i>Methods:</i></b> This prospective cohort study was set across 12 UK foetal medicine centres. All cases underwent QF-PCR, CMA, and ES, and the diagnostic yield in <i>n</i> = 147 cases of prenatally diagnosed CHD was assessed. <b><i>Results:</i></b> In 34.7% (<i>n</i> = 51/147), a genetic diagnosis was obtained. Using a stepwise testing strategy, the diagnostic yield for QF-PCR, CMA, and ES was 15.6% (<i>n</i> = 23/147), 13.7% (<i>n</i> = 17/124), and 10.2% (<i>n</i> = 11/107), respectively. Abnormal QF-PCR/shunt (septal) defects 31.4% (<i>n</i> = 11/35), <i>p</i> = 0.046, and abnormal CMA/conotruncal anomalies 22.7% (<i>n</i> = 10/44), <i>p</i> = 0.04, had significant associations. Monogenic variants were commonest in complex CHD 36.4% (<i>n</i> = 4/11). Multisystem CHD had a greater diagnostic yield overall compared to isolated OR 2.41 (95% CI, 1.1–5.1), particularly in association with brain and gastrointestinal tract anomalies. The proportion of variants of uncertain significance was 4.7% (<i>n</i> = 5/107) with ES, with none in the CMA group. <b><i>Conclusion:</i></b> In the era of prenatal ES, there remains an important role for QF-PCR and CMA. Identification of monogenic pathologic variants further allows delineation of prognosis in CHD.

Association Between Enteral Nutrition and Necrotizing Enterocolitis in Neonates with Congenital Heart Disease

2021 ◽  
Author(s):  
Joann Herridge ◽  
Seth Gray ◽  
Sarah Wedde ◽  
Shayanthan Parameswaran ◽  
Helena Frndova ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Enteral Nutrition ◽  
Necrotizing Enterocolitis ◽  
Congenital Heart

Advanced maternal age and risk of adverse perinatal outcome among women with congenital heart disease: A nationwide register‐based cohort study

2020 ◽  
Vol 34 (6) ◽  
pp. 637-644
Author(s):  
Stine Kloster ◽  
Anne‐Marie Nybo Andersen ◽  
Søren Paaske Johnsen ◽  
Dorte Guldbrand Nielsen ◽  
Annette Kjær Ersbøll ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Cohort Study ◽  
Heart Disease ◽  
Perinatal Outcome ◽  
Maternal Age ◽  
Congenital Heart ◽  
Advanced Maternal Age ◽  
Adverse Perinatal Outcome

Outcome of preterm infants with congenital heart disease

2000 ◽  
Vol 137 (5) ◽  
pp. 653-659 ◽  
Author(s):  
Ellen Dees ◽  
Hwei Lin ◽  
Robert B. Cotton ◽  
Thomas P. Graham ◽  
Debra A. Dodd
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Preterm Infants ◽  
Congenital Heart
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