Inhaled nitric oxide in preterm infants with prolonged preterm rupture of the membranes: a case series

2015 ◽  
Vol 35 (4) ◽  
pp. 304-306 ◽  
Author(s):  
J Semberova ◽  
S M O'Donnell ◽  
J Franta ◽  
J Miletin
Keyword(s):  
Nitric Oxide ◽  
Preterm Infants ◽  
Case Series ◽  
Inhaled Nitric Oxide

scholarly journals Inhaled Nitric Oxide at Birth Reduces Pulmonary Vascular Resistance and Improves Oxygenation in Preterm Lambs

Children ◽  
2021 ◽  
Vol 8 (5) ◽  
pp. 378
Author(s):  
Satyan Lakshminrusimha ◽  
Sylvia F. Gugino ◽  
Krishnamurthy Sekar ◽  
Stephen Wedgwood ◽  
Carmon Koenigsknecht ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Pulmonary Hypertension ◽  
Pulmonary Vascular Resistance ◽  
Preterm Infants ◽  
Vascular Resistance ◽  
Inhaled Nitric Oxide ◽  
Persistent Pulmonary Hypertension ◽  
Inhaled No ◽  
Birth Preterm

Resuscitation with 21% O2 may not achieve target oxygenation in preterm infants and in neonates with persistent pulmonary hypertension of the newborn (PPHN). Inhaled nitric oxide (iNO) at birth can reduce pulmonary vascular resistance (PVR) and improve PaO2. We studied the effect of iNO on oxygenation and changes in PVR in preterm lambs with and without PPHN during resuscitation and stabilization at birth. Preterm lambs with and without PPHN (induced by antenatal ductal ligation) were delivered at 134 d gestation (term is 147–150 d). Lambs without PPHN were ventilated with 21% O2, titrated O2 to maintain target oxygenation or 21% O2 + iNO (20 ppm) at birth for 30 min. Preterm lambs with PPHN were ventilated with 50% O2, titrated O2 or 50% O2 + iNO. Resuscitation with 21% O2 in preterm lambs and 50%O2 in PPHN lambs did not achieve target oxygenation. Inhaled NO significantly decreased PVR in all lambs and increased PaO2 in preterm lambs ventilated with 21% O2 similar to that achieved by titrated O2 (41 ± 9% at 30 min). Inhaled NO increased PaO2 to 45 ± 13, 45 ± 20 and 76 ± 11 mmHg with 50% O2, titrated O2 up to 100% and 50% O2 + iNO, respectively, in PPHN lambs. We concluded that iNO at birth reduces PVR and FiO2 required to achieve target PaO2.

Inhaled nitric oxide in very preterm infants with severe respiratory distress syndrome

2006 ◽  
Vol 95 (9) ◽  
pp. 1116-1123 ◽  
Author(s):  
Carlo Dani ◽  
Giovanna Bertini ◽  
Marco Pezzati ◽  
Luca Filippi ◽  
Alessandra Cecchi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Preterm Infants ◽  
Distress Syndrome ◽  
Inhaled Nitric Oxide ◽  
Severe Respiratory Distress ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Severe Respiratory Distress Syndrome

scholarly journals Inflammatory Mediators in Tracheal Aspirates of Preterm Infants Participating in a Randomized Trial of Inhaled Nitric Oxide

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0169352 ◽  
Author(s):  
Mandy Laube ◽  
Elena Amann ◽  
Ulrike Uhlig ◽  
Yang Yang ◽  
Hans W. Fuchs ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Randomized Trial ◽  
Preterm Infants ◽  
Inflammatory Mediators ◽  
Inhaled Nitric Oxide ◽  
Tracheal Aspirates

scholarly journals Effects of inhaled nitric oxide in high risk preterm infants

1997 ◽  
Vol 42 (3) ◽  
pp. 411-411
Author(s):  
Nimish V Subhedar ◽  
Ben N J Shaw
Keyword(s):  
Nitric Oxide ◽  
High Risk ◽  
Preterm Infants ◽  
Inhaled Nitric Oxide
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