scholarly journals Packed red blood cell transfusion is not associated with increased risk of necrotizing enterocolitis in premature infants

2014 ◽  
Vol 34 (11) ◽  
pp. 858-862 ◽  
Author(s):  
R Sharma ◽  
D F Kraemer ◽  
R M Torrazza ◽  
V Mai ◽  
J Neu ◽  
...  
Keyword(s):  
Blood Cell ◽  
Necrotizing Enterocolitis ◽  
Premature Infants ◽  
Red Blood Cell ◽  
Red Blood Cell Transfusion ◽  
Increased Risk

scholarly journals Red blood cell transfusion in premature infants leads to worse necrotizing enterocolitis outcomes

2017 ◽  
Vol 213 ◽  
pp. 158-165 ◽  
Author(s):  
Kellie E. Cunningham ◽  
Frances C. Okolo ◽  
Robyn Baker ◽  
Kevin P. Mollen ◽  
Misty Good
Keyword(s):  
Blood Cell ◽  
Necrotizing Enterocolitis ◽  
Premature Infants ◽  
Red Blood Cell ◽  
Red Blood Cell Transfusion

Allogeneic Leukocyte-Reduced Red Blood Cell Transfusion Is Associated with Postoperative Infectious Complications and Cancer Recurrence after Colon Cancer Resection

2019 ◽  
Vol 37 (2) ◽  
pp. 163-170 ◽  
Author(s):  
Andrew-Paul Deeb ◽  
Christopher T. Aquina ◽  
John R.T. Monson ◽  
Neil Blumberg ◽  
Adan Z. Becerra ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cancer Recurrence ◽  
Infectious Complications ◽  
Oncologic Outcomes ◽  
Red Blood Cell Transfusion ◽  
Elective Resection ◽  
Increased Risk ◽  
The Impact

Background/Aims: Transfusion rates in colon cancer surgery are traditionally very high. Allogeneic red blood cell (RBC) transfusions are reported to induce immunomodulation that contributes to infectious morbidity and adverse oncologic outcomes. In an effort to attenuate these effects, the study institution implemented a universal leukocyte reduction protocol. The purpose of this study was to examine the impact of leukocyte-reduced (LR) transfusions on postoperative infectious complications, recurrence-free survival, and overall survival (OS). Methods: In a retrospective study, patients with stage I–III adenocarcinoma of the colon from 2003 to 2010 who underwent elective resection were studied. The primary outcome measures were postoperative infectious complications and recurrence-free and OS in patients that received a transfusion. Bivariate and multivariable regression analyses were performed for each endpoint. Results: Of 294 patients, 66 (22%) received a LR RBC transfusion. After adjustment, transfusion of LR RBCs was found to be independently associated with increased infectious complications (OR 3.10, 95% CI 1.24–7.73), increased odds of cancer recurrence (hazard ratio [HR] 3.74, 95% CI 1.94–7.21), and reduced OS when ≥3 units were administered (HR 2.24, 95% CI 1.12–4.48). Conclusion: Transfusion of LR RBCs is associated with an increased risk of infectious complications and worsened survival after elective surgery for colon cancer, irrespective of leukocyte reduction.

scholarly journals RhD Immunization Despite Adequate Immunoprophylaxis: Role of Fc Gamma Receptor Gene Polymorphisms

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 759-759
Author(s):  
Tamara C Stegmann ◽  
Sietse Q Nagelkerke ◽  
Dian van Winkelhorst ◽  
Taco W Kuijpers ◽  
Gestur Vidarsson ◽  
...  
Keyword(s):  
Risk Factors ◽  
Genetic Variation ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Potential Risk ◽  
Caesarian Section ◽  
Red Blood Cell Transfusion ◽  
Control Group ◽  
Increased Risk ◽  
Potential Risk Factors

Abstract Introduction: One of the most effective immunological interventions in clinical medicine is the prevention of hemolytic disease of the newborn by prophylactic Rh immune globulin (Rh-Ig) therapy. The administration of ante- and postnatal Rh-Ig has reduced the risk of RhD immunization in the Netherlands from 17% to a mere 0.31%, yet its mechanism of action is still unknown. To gain more insight into the possible working mechanism of the Rh-Ig prophylaxis we analyzed potential risk factors and genotyped all known IgG-Fc receptor (protein FcγR, gene FCGR) variants known to date, on a cohort of Dutch women who failed Rh-Ig prophylaxis and developed anti-D antibodies. Adequate Rh-Ig immunoprophylaxis was defined as an antenatal and postnatal prophylaxis of 1,000 IU (200 µg) in both current and previous pregnancies, according to the Dutch guidelines. Material and Methods: Between 1999 and 2013 we identified 274 women who produced anti-D antibodies. Through a structured questionnaire we collected information about Rh-Ig prophylaxis and additional clinical data for potential risk factors. In 122 cases, adequate Rh-Ig prophylaxis was given, and clinical risk factors for fetal maternal hemorrhage (FMH) could be collected. Their clinical circumstances were compared to a control group of 339 randomly selected pregnant women. The Rh-Ig therapy failure of 57 of those women could not be explained through our risk factor analysis. From these 57 cases, DNA was obtained, and used for the FcγR-specific multiplex ligation-dependent probe amplification (MLPA) assay, identifying both single nucleotide polymorphisms and copy number variations in the FCGR locus. The results were compared to a control group of 200 healthy donors. Results: A history of red blood cell transfusion (p=0.05) and caesarean section (p<0.0001) were identified to be independent risk factors for RhD immunization. All other described risk factors for FMH such as miscarriage, termination of pregnancy, or invasive diagnostic procedures, requiring an additional Rh-Ig dose according to the guidelines, were not found to increase the risk of immunoprophylaxis failure. RhD-immunization due to caesarian section or red blood cell transfusion accounted for 53% of our cohort, suggesting an alternative explanation for the production of Rh-Ig alloantibodies in the remaining 47% of the cases - despite adequate amount of prophylaxis given in current and previous pregnancies. We therefore postulate the existence of a genetic variation that puts women at increased risk for RhD immunization during pregnancy. To test this hypothesis we analyzed the genetic variation in the FCGR locus and found a significantly (p=0.02) increased prevalence of the FCGR2 -ORF, expressing a functional copy of the activating FcγRIIc, which is otherwise a pseudogene. Strikingly, the prevalence of the 2B.4-promotor haplotype of the FCGR2B gene, associated with a 1.5 fold increase of the inhibitory FcγRIIb, was strongly (p=0.0001) increased. Conclusion: Caesarian section and red blood cell transfusion are risk factors that increase RhD immunization during pregnancies, accounting for about half failed Rh-Ig prophylactic cases. Genetic variation in the FCGR-gene might be a possible explanation for increased immunization risk. In our cohort we encountered a significantly increased frequency of individuals expressing FcγRIIc, along with a polymorphism encoding for a higher expression of the inhibitory receptor FcγRIIb, suggesting these genes to influence immune responses to RBC in a manner previously unrecognized. Disclosures No relevant conflicts of interest to declare.

Risk of Necrotizing Enterocolitis Following Packed Red Blood Cell Transfusion in Very Low Birth Weight Infants

2019 ◽  
Vol 86 (4) ◽  
pp. 347-353 ◽  
Author(s):  
Waricha Janjindamai ◽  
Arunee Prapruettrong ◽  
Anucha Thatrimontrichai ◽  
Supaporn Dissaneevate ◽  
Gulawadee Maneenil ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Blood Cell ◽  
Necrotizing Enterocolitis ◽  
Red Blood Cell ◽  
Very Low Birth Weight ◽  
Red Blood Cell Transfusion ◽  
Low Birth Weight Infants

Copper, zinc and iron levels in premature infants following red blood cell transfusion

2016 ◽  
Vol 38 ◽  
pp. 126-130
Author(s):  
Murat Kizilgun ◽  
Sahin Takci ◽  
Pinar Erkekoglu ◽  
Ali Asci ◽  
Aylin Balci ◽  
...  
Keyword(s):  
Blood Cell ◽  
Premature Infants ◽  
Red Blood Cell ◽  
Red Blood Cell Transfusion ◽  
Copper Zinc

Necrotizing enterocolitis and red blood cell transfusion

2011 ◽  
Vol 159 (2) ◽  
pp. 354-355 ◽  
Author(s):  
Stefano Ghirardello ◽  
Carlo Andrea Lonati ◽  
Elisa Dusi ◽  
Lorenza Pugni ◽  
Fabio Mosca
Keyword(s):  
Blood Cell ◽  
Necrotizing Enterocolitis ◽  
Red Blood Cell ◽  
Red Blood Cell Transfusion
Sign in / Sign up

Export Citation Format

Share Document