Isolated mild white matter signal changes in preterm infants: a regional approach for comparison of cranial ultrasound and MRI findings

2014 ◽  
Vol 34 (6) ◽  
pp. 476-482 ◽  
Author(s):  
M Weinstein ◽  
D Ben Bashat ◽  
V Gross-Tsur ◽  
Y Leitner ◽  
I Berger ◽  
...  
Keyword(s):  
White Matter ◽  
Preterm Infants ◽  
Cranial Ultrasound ◽  
Mri Findings ◽  
Regional Approach ◽  
Signal Changes

scholarly journals Comparing brain white matter on sequential cranial ultrasound and MRI in very preterm infants

2008 ◽  
Vol 50 (9) ◽  
pp. 799-811 ◽  
Author(s):  
Lara M. Leijser ◽  
Lishya Liauw ◽  
Sylvia Veen ◽  
Inge P. de Boer ◽  
Frans J. Walther ◽  
...  
Keyword(s):  
White Matter ◽  
Preterm Infants ◽  
Cranial Ultrasound ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Brain White Matter

scholarly journals Bilateral Telencephalic Gliomatosis Cerebri in a Dog

2014 ◽  
Vol 2014 ◽  
pp. 1-5
Author(s):  
Mario Ricciardi ◽  
Antonio De Simone ◽  
Pasquale Giannuzzi ◽  
Maria Teresa Mandara ◽  
Alice Reginato ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
White Matter ◽  
Mass Effect ◽  
Gliomatosis Cerebri ◽  
Imaging Findings ◽  
Mri Findings ◽  
Intact Male ◽  
Presumptive Diagnosis ◽  
Atypical Cells ◽  
Signal Changes

An 8-year-old intact male Lagotto Romagnolo was presented with forebrain signs. Neuroanatomic localization was diffuse prosencephalon. MRI revealed diffuse, bilateral, and symmetric T2 and FLAIR hyperintensities in the parieto-occipital white matter and corpus callosum. No mass effect or contrast enhancement was noted. Analysis of cerebrospinal fluid revealed normal protein content and mild mononuclear pleocytosis. Atypical cells were not identified. 15 days later because of the worsening of clinical condition the patient was euthanized upon owner’s request. Neuropathological investigations were consistent with gliomatosis cerebri (GC). Such an unusual imaging pattern appeared similar to some cases of human GC and to a previous reported case in a dog, suggesting a possible repeatable imaging findings for this rare brain neoplasm. GC should be included in the MRI differentials for diffuse bilateral white matter signal changes and specific MRI findings described in this report may help in reaching a presumptive diagnosis of this tumor.

scholarly journals Consensus Approach for Standardizing the Screening and Classification of Preterm Brain Injury Diagnosed With Cranial Ultrasound: A Canadian Perspective

2021 ◽  
Vol 9 ◽  
Author(s):  
Khorshid Mohammad ◽  
James N. Scott ◽  
Lara M. Leijser ◽  
Hussein Zein ◽  
Jehier Afifi ◽  
...  
Keyword(s):  
Brain Injury ◽  
White Matter ◽  
Preterm Infants ◽  
Intraventricular Hemorrhage ◽  
White Matter Injury ◽  
Cranial Ultrasound ◽  
Consensus Approach ◽  
Germinal Matrix ◽  
Very Preterm Infants ◽  
Very Preterm

Acquired brain injury remains common in very preterm infants and is associated with significant risks for short- and long-term morbidities. Cranial ultrasound has been widely adopted as the first-line neuroimaging modality to study the neonatal brain. It can reliably detect clinically significant abnormalities that include germinal matrix and intraventricular hemorrhage, periventricular hemorrhagic infarction, post-hemorrhagic ventricular dilatation, cerebellar hemorrhage, and white matter injury. The purpose of this article is to provide a consensus approach for detecting and classifying preterm brain injury to reduce variability in diagnosis and classification between neonatologists and radiologists. Our overarching goal with this work was to achieve homogeneity between different neonatal intensive care units across a large country (Canada) with regards to classification, timing of brain injury screening and frequency of follow up imaging. We propose an algorithmic approach that can help stratify different grades of germinal matrix-intraventricular hemorrhage, white matter injury, and ventricular dilatation in very preterm infants.

Frequently encountered cranial ultrasound features in the white matter of preterm infants: Correlation with MRI

2009 ◽  
Vol 13 (4) ◽  
pp. 317-326 ◽  
Author(s):  
Lara M. Leijser ◽  
Latha Srinivasan ◽  
Mary A. Rutherford ◽  
Gerda van Wezel-Meijler ◽  
Serena J. Counsell ◽  
...  
Keyword(s):  
White Matter ◽  
Preterm Infants ◽  
Cranial Ultrasound ◽  
Ultrasound Features

scholarly journals Is sequential cranial ultrasound reliable for detection of white matter injury in very preterm infants?

2010 ◽  
Vol 52 (5) ◽  
pp. 397-406 ◽  
Author(s):  
Lara M. Leijser ◽  
Francisca T. de Bruïne ◽  
Jeroen van der Grond ◽  
Sylke J. Steggerda ◽  
Frans J. Walther ◽  
...  
Keyword(s):  
White Matter ◽  
Preterm Infants ◽  
White Matter Injury ◽  
Cranial Ultrasound ◽  
Very Preterm Infants ◽  
Very Preterm

scholarly journals Incidence of brain lesions in moderate-late preterm infants assessed by cranial ultrasound and MRI: The BIMP-study

2020 ◽  
pp. 109500
Author(s):  
V. Boswinkel ◽  
M.F. Krüse-Ruijter ◽  
J. Nijboer - Oosterveld ◽  
I.M. Nijholt ◽  
M.A. Edens ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Brain Lesions ◽  
Late Preterm ◽  
Cranial Ultrasound ◽  
Late Preterm Infants

scholarly journals Factors associated with neurodevelopment in preterm infants with systematic inflammation

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Eun Sun Lee ◽  
Ee-Kyung Kim ◽  
Seung han Shin ◽  
Young-Hun Choi ◽  
Young Hwa Jung ◽  
...  
Keyword(s):  
White Matter ◽  
Preterm Infants ◽  
Systemic Inflammation ◽  
Head Circumference ◽  
Brain Mri ◽  
White Matter Injury ◽  
Social Emotional ◽  
Postmenstrual Age ◽  
Neurodevelopmental Impairment ◽  
Near Term

Abstract Background Several studies have suggested that adverse neurodevelopment could be induced by systemic inflammation in preterm infants. We aimed to investigate whether preterm infants with systemic inflammation would have impaired neurodevelopment and which biomarkers and neurophysiologic studies during inflammation are associated with poor neurodevelopment. Methods This prospective cohort study enrolled infants born before 30 weeks of gestation or with birth weight < 1250 g. Infants were grouped according to the presence of systemic inflammation: Control (no inflammation, n = 49), I (systemic inflammation, n = 45). Blood and cerebrospinal fluid samples for markers of brain injury and inflammation were collected and amplitude-integrated electroencephalography (aEEG) was performed within 4 h of septic workup. We evaluated aEEG at 35 weeks postmenstrual age (PMA), head circumference at 36 weeks PMA, and brain MRI at discharge. The Bayley Scales of Infant and Toddler Development III (Bayley-III) was performed at a corrected age (CA) of 18 months. Results The I group had more white matter injuries (2 vs. 26.7%, Control vs. I, respectively) at the time of discharge, lower brain functional maturation (9.5 vs. 8), and smaller head size (z-score − 1.45 vs. -2.12) at near-term age and poorer neurodevelopment at a CA of 18 months than the control (p < 0.05). Among the I group, the proportion of immature neutrophils (I/T ratios) and IL-1 beta levels in the CSF were associated with aEEG measures at the day of symptom onset (D0). Seizure spike on aEEG at D0 was significantly correlated with motor and social-emotional domains of Bayley-III (p < 0.05). The I/T ratio and CRP and TNF-α levels of blood at D0, white matter injury on MRI at discharge, head circumference and seizure spikes on aEEG at near-term age were associated with Bayley-III scores at a CA of 18 months. Conclusions Systemic inflammation induced by clinical infection and NEC are associated with neurodevelopmental impairment in preterm infants. The seizure spike on aEEG, elevated I/T ratio, CRP, and plasma TNF-alpha during inflammatory episodes are associated with poor neurodevelopment.

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