scholarly journals Novel NKX2.1 mutation associated with hypothyroidism and lethal respiratory failure in a full-term neonate

2013 ◽  
Vol 33 (2) ◽  
pp. 157-160 ◽  
Author(s):  
E S Gillett ◽  
G H Deutsch ◽  
M J Bamshad ◽  
R M McAdams ◽  
P C Mann
NeoReviews ◽  
2020 ◽  
Vol 21 (11) ◽  
pp. e768-e771
Author(s):  
Suzanne Al-Hamad ◽  
Nicholas Pietris ◽  
Suma B. Hoffman ◽  
Alison J. Falck
Keyword(s):  

PEDIATRICS ◽  
1993 ◽  
Vol 92 (1) ◽  
pp. 135-139
Author(s):  
Hatem Khammash ◽  
Max Perlman ◽  
Julian Wojtulewicz ◽  
Michael Dunn

Objective. In light of the paucity of published data on the use of surfactant in full-term infants with respiratory failure due to meconium aspiration syndrome and respiratory distress syndrome, we report our experience with this therapy. Our goal was to explore possible justification for randomized controlled trials of surfactant treatment in similar patients at an earlier, less severe stage of the disease. Methods. Retrospective consecutive case series of 20 infants with severe meconium aspiration syndrome and 29 infants with severe respiratory distress syndrome who received bovine surfactant between March 1990 and December 1992 in three neonatal intensive care units in a regionalized setting. Outcome of treatment was assessed by comparing changes in several respiratory indices including the oxygenation index, between 4 and 6 hours and 1 and 3 hours before and after the first dose of surfactant. Differences were analyzed using analysis of variance for repeated measures, with treatment and time as co-variates. Results. In the meconium aspiration group the mean oxygenation index decreased from 36 ± 12 at 1 to 3 hours presurfactant to 24 ± 14 at 1 to 3 hours postsurfactant (P < .001). In the patients with respiratory distress syndrome the mean oxygenation index fell from 30 ± 17 at 1 to 3 hours presurfactant to 12 ± 6 at 1 to 3 hours postsurfactant (P = .0001). Three of 20 patients with meconium aspiration syndrome and 3 of 29 patients with respiratory distress syndrome received extracorporeal membrane oxygenation. Conclusions. Surfactant therapy in full-term infants with respiratory failure due to the meconium aspiration and respiratory distress syndromes is often effective in improving gas exchange. A randomized controlled trial of surfactant therapy at an earlier stage in the course of the illness should be performed.


2012 ◽  
Vol 33 (1) ◽  
pp. 15-20 ◽  
Author(s):  
J C Barrera-de León ◽  
R Cervantes-Munguía ◽  
C Vásquez ◽  
M A Higareda-Almaraz ◽  
A Bravo-Cuellar ◽  
...  

2011 ◽  
pp. 667 ◽  
Author(s):  
Yoshitaka Kubo ◽  
Ogasawara ◽  
Akira Kurose ◽  
Hiroshi Kashimura ◽  
Takahiro Koji ◽  
...  

PEDIATRICS ◽  
1973 ◽  
Vol 51 (2) ◽  
pp. 311-311
Author(s):  
Morton L. Cohen

In reporting the third case of Wilson-Mikity syndrome in a full-term neonate, Drs. Keidel and Feingold1 appear instead to have described a classic case of meconium aspiration syndrome. Their patient, delivered with difficulty at 41 weeks' gestation, aspirated meconium at the time of delivery and was severely asphyxiated at birth. Respiratory distress developed after resuscitation and the baby was noted to have "diffuse granularity of both lung fields and hyperinflation indicating meconium aspiration." Later, when the chest film showed "hyperexpanded lungs with depressed diaphragms and cyst-like foci alternating with coarse infiltrates" their diagnostic impression apparently changed to Mikity-Wilson syndrome.


2019 ◽  
Vol 32 (2) ◽  
pp. 745
Author(s):  
AdityaP Singh ◽  
ArunK Gupta ◽  
Rajlaxmi Pardeshi ◽  
Vinay Mathur

2019 ◽  
Vol 09 (02) ◽  
pp. e144-e146
Author(s):  
Nadereh Taee ◽  
Mojgan Goodarzi ◽  
Mohammad Safdari ◽  
Amir Bajelan

AbstractPentalogy of Cantrell (PC) is an uncommon congenital disorder characterized by severe defects in the chest and abdomen, including abdominal visceral prolapsed via umbilical cord (omphalocele), defect in the lower part of the sternum, defect in the front of the diaphragm, defects in the anterior part of the pericardium, and the ectopiacordis. Here, we report a 2-hour-old girl, weighing 3,500 g, who was referred to Shahid Madani Hospital in Khorramabad due to the large omphalocele on her chest with pulsating mass above it. The baby was the first child of a 24-year-old mother who was born with an uncomplicated vaginal delivery. Very rare cases of PC are born as a term new-born.


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