scholarly journals Prediction of postnatal outcomes in congenital diaphragmatic hernia using MRI signal intensity of the fetal lung

2010 ◽  
Vol 31 (4) ◽  
pp. 269-273 ◽  
Author(s):  
K Terui ◽  
A Omoto ◽  
H Osada ◽  
T Hishiki ◽  
T Saito ◽  
...  
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Signal Intensity ◽  
Fetal Lung

scholarly journals Amniotic fluid stem cell extracellular vesicles promote fetal lung branching and cell differentiation in experimental congenital diaphragmatic hernia

2022 ◽  
Author(s):  
Kasra Khalaj ◽  
Rebeca Lopes Figueira ◽  
Lina Antounians ◽  
Sree Gandhi ◽  
Matthew Wales ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Congenital Diaphragmatic Hernia ◽  
Extracellular Vesicles ◽  
Diaphragmatic Hernia ◽  
Lung Development ◽  
Pulmonary Hypoplasia ◽  
Fetal Lung ◽  
Branching Morphogenesis ◽  
Neuroendocrine Cells ◽  
Beta Catenin

Pulmonary hypoplasia secondary to congenital diaphragmatic hernia (CDH) is characterized by impaired branching morphogenesis and differentiation. We have previously demonstrated that administration of extracellular vesicles derived from rat amniotic fluid stem cells (AFSC-EVs) rescues development of hypoplastic lungs at the pseudoglandular and alveolar stages in rodent models of CDH. Herein, we tested whether AFSC-EVs exert their regenerative effects at the canalicular and saccular stages, as these are translationally relevant for clinical intervention. To induce fetal pulmonary hypoplasia, we gavaged rat dams with nitrofen at embryonic day 9.5 and demonstrated that nitrofen-exposed lungs had impaired branching morphogenesis, dysregulated signaling pathways relevant to lung development (FGF10/FGFR2, ROBO/SLIT, Ephrin, Neuropilin 1, beta-catenin) and impaired epithelial and mesenchymal cell marker expression at both stages. AFSC-EVs administered to nitrofen-exposed lung explants rescued airspace density and increased the expression levels of key factors responsible for branching morphogenesis. Moreover, AFSC-EVs rescued the expression of alveolar type 1 and 2 cell markers at both canalicular and saccular stages, and restored markers of club, ciliated epithelial, and pulmonary neuroendocrine cells at the saccular stage. AFSC-EV treated lungs also had restored markers of lipofibroblasts and PDGFRA+ cells to control levels at both stages. EV tracking showed uptake of AFSC-EV RNA cargo throughout the fetal lung and an mRNA-miRNA network analysis identified that several miRNAs responsible for regulating lung development processes were contained in the AFSC-EV cargo. These findings suggest that AFSC-EV based therapies hold potential for restoring fetal lung growth and maturation in babies with pulmonary hypoplasia secondary to CDH.

Lipocalin 2 as a new biomarker for fetal lung hypoplasia in congenital diaphragmatic hernia

2016 ◽  
Vol 462 ◽  
pp. 71-76 ◽  
Author(s):  
Hiroyuki Tsuda ◽  
Tomomi Kotani ◽  
Tomoko Nakano ◽  
Kenji Imai ◽  
Shima Hirako ◽  
...  
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Fetal Lung ◽  
Lung Hypoplasia ◽  
Lipocalin 2

scholarly journals Local Fetal Lung Renin-Angiotensin System as a Target to Treat Congenital Diaphragmatic Hernia

2011 ◽  
Vol 18 (2) ◽  
pp. 231-243 ◽  
Author(s):  
Cristina Nogueira-Silva ◽  
Emanuel Carvalho-Dias ◽  
Paulina Piairo ◽  
Susana Nunes ◽  
Maria J. Baptista ◽  
...  
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Renin Angiotensin System ◽  
Fetal Lung ◽  
Angiotensin System ◽  
Renin Angiotensin

scholarly journals VP20.02: Cost‐effective fetal lung volumetry for assessment of congenital diaphragmatic hernia

2020 ◽  
Vol 56 (S1) ◽  
pp. 138-138
Author(s):  
R. Corroenne ◽  
A.N. Shetty ◽  
K. Zhu ◽  
R.M. Johnson ◽  
A. Mehollin‐Ray ◽  
...  
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Cost Effective ◽  
Fetal Lung

Assessment of fetal lung volumes and liver herniation with magnetic resonance imaging in congenital diaphragmatic hernia

2000 ◽  
Vol 183 (5) ◽  
pp. 1067-1069 ◽  
Author(s):  
Danielle S. Walsh ◽  
Anne M. Hubbard ◽  
Oluyinka O. Olutoye ◽  
Lori J. Howell ◽  
Timothy M. Crombleholme ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Fetal Lung ◽  
Resonance Imaging ◽  
Lung Volumes ◽  
Liver Herniation

Fetal Lung Growth in Congenital Diaphragmatic Hernia

2005 ◽  
Vol 21 (1) ◽  
pp. 39-44 ◽  
Author(s):  
F. Bargy ◽  
S. Beaudoin ◽  
P. Barbet
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Fetal Lung ◽  
Lung Growth

scholarly journals P09.11: What is the precision of 3DUS in estimating fetal lung volume in congenital diaphragmatic hernia?

2004 ◽  
Vol 24 (3) ◽  
pp. 319-320
Author(s):  
R. Ruano ◽  
J. Martinovic ◽  
A. Benachi ◽  
L. Joubin ◽  
M. C. Aubry ◽  
...  
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Lung Volume ◽  
Fetal Lung
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