scholarly journals Transcription Factor CTIP2 Maintains Hair Follicle Stem Cell Pool and Contributes to Altered Expression of LHX2 and NFATC1

2015 ◽  
Vol 135 (11) ◽  
pp. 2593-2602 ◽  
Author(s):  
Shreya Bhattacharya ◽  
Heather Wheeler ◽  
Mark Leid ◽  
Gitali Ganguli-Indra ◽  
Arup K. Indra
Keyword(s):  
Transcription Factor ◽  
Stem Cell ◽  
Hair Follicle ◽  
Altered Expression ◽  
Cell Pool ◽  
Hair Follicle Stem Cell ◽  
Stem Cell Pool

scholarly journals Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool

Nature ◽  
2015 ◽  
Vol 522 (7554) ◽  
pp. 94-97 ◽  
Author(s):  
Kailin R. Mesa ◽  
Panteleimon Rompolas ◽  
Giovanni Zito ◽  
Peggy Myung ◽  
Thomas Y. Sun ◽  
...  
Keyword(s):  
Cell Death ◽  
Stem Cell ◽  
Hair Follicle ◽  
Cell Pool ◽  
Hair Follicle Stem Cell ◽  
Stem Cell Pool

Abstract B49: Prox1 Transcription factor promotes colorectal cancer growth by expanding the Lgr5-positive stem cell pool.

2013 ◽  
Author(s):  
Zoltan Wiener ◽  
Jenny Högström ◽  
Ville Hyvönen ◽  
Tanja Holopainen ◽  
Arja Band ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Transcription Factor ◽  
Stem Cell ◽  
Cancer Growth ◽  
Cell Pool ◽  
Stem Cell Pool

scholarly journals The EMT transcription factor Zeb2 controls adult murine hematopoietic differentiation by regulating cytokine signaling

Blood ◽  
2017 ◽  
Vol 129 (4) ◽  
pp. 460-472 ◽  
Author(s):  
Jin Li ◽  
Tamara Riedt ◽  
Steven Goossens ◽  
Carmen Carrillo García ◽  
Sabrina Szczepanski ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Stem Cell ◽  
Early Stage ◽  
Primary Myelofibrosis ◽  
Pool Size ◽  
Cytokine Signaling ◽  
Hematopoietic Differentiation ◽  
Cell Pool ◽  
Key Points ◽  
Stem Cell Pool

Key Points Zeb2 controls stem cell pool size and lineage fidelity. Zeb2 deletion promotes a myeloproliferative phenotype resembling the early stage of primary myelofibrosis.

scholarly journals Transcription Factor DLX5 Promotes Hair Follicle Stem Cell Differentiation by Regulating the c-MYC/microRNA-29c-3p/NSD1 Axis

2021 ◽  
Vol 9 ◽  
Author(s):  
Bojie Lin ◽  
Jiangying Zhu ◽  
Guoqian Yin ◽  
Mingde Liao ◽  
Guanyu Lin ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Stem Cell ◽  
Hair Follicle ◽  
Promoter Region ◽  
Cell Function ◽  
Adult Stem Cell ◽  
Stem Cell Differentiation ◽  
Model Systems ◽  
Hair Follicle Stem Cell

IntroductionAdult stem cell function has been one of the most intensively explored areas of biological and biomedical research, with hair follicle stem cells serving as one of the best model systems. This study explored the role of the transcription factor DLX5 in regulating hair follicle stem cell (HFSC) differentiation.MethodsHFSCs were isolated, characterized, and assessed for their expression of DLX5, c-MYC, NSD1, and miR-29c-3p using RT-qPCR, Western blot analysis, or immunofluorescence. Next, the ability of HFSCs to proliferate as well as differentiate into either sebaceous gland cells or epidermal cells was determined. The binding of DLX5 to the c-MYC promoter region, the binding of c-MYC to the miR-29c-3p promoter region, and the binding of miR-29c-3p to the 3′-UTR of NSD1 mRNA were verified by luciferase activity assay and ChIP experiments.ResultsDLX5 was highly expressed in differentiated HFSCs. DLX5 transcriptionally activated c-MYC expression to induce HFSC differentiation. c-MYC was able to bind the miR-29c-3p promoter and thus suppressed its expression. Without miR-29c-3p mediated suppression, NSD1 was then able to promote HFSC differentiation. These in vitro experiments suggested that DLX5 could promote HFSC differentiation via the regulation of the c-MYC/miR-29c-3p/NSD1 axis.DiscussionThis study demonstrates that DLX5 promotes HFSC differentiation by modulating the c-MYC/miR-29c-3p/NSD1 axis and identifies a new mechanism regulating HFSC differentiation.

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