scholarly journals Crosstalk between Keratinocytes and T Cells in a 3D Microenvironment: A Model to Study Inflammatory Skin Diseases

2014 ◽  
Vol 134 (3) ◽  
pp. 719-727 ◽  
Author(s):  
Ellen H. van den Bogaard ◽  
Geuranne S. Tjabringa ◽  
Irma Joosten ◽  
Mieke Vonk-Bergers ◽  
Esther van Rijssen ◽  
...  
Keyword(s):  
T Cells ◽  
Skin Diseases ◽  
Inflammatory Skin Diseases ◽  
3D Microenvironment ◽  
Inflammatory Skin

γδ T cells and inflammatory skin diseases

2020 ◽  
Vol 298 (1) ◽  
pp. 61-73
Author(s):  
Mia Hamilton Jee ◽  
Veronika Mraz ◽  
Carsten Geisler ◽  
Charlotte Menné Bonefeld
Keyword(s):  
T Cells ◽  
Skin Diseases ◽  
Γδ T Cells ◽  
Inflammatory Skin Diseases ◽  
Inflammatory Skin

Interactions of epidermal cells and T cells in inflammatory skin diseases

1990 ◽  
Vol 23 (6) ◽  
pp. 1312-1317 ◽  
Author(s):  
Ole Baadsgaard ◽  
Gary J. Fisher ◽  
John J. Voorhees ◽  
Kevin D. Cooper
Keyword(s):  
T Cells ◽  
Skin Diseases ◽  
Epidermal Cells ◽  
Inflammatory Skin Diseases ◽  
Inflammatory Skin

scholarly journals High-scatter T cells: a reliable biomarker for malignant T cells in cutaneous T-cell lymphoma

Blood ◽  
2011 ◽  
Vol 117 (6) ◽  
pp. 1966-1976 ◽  
Author(s):  
Rachael A. Clark ◽  
Jeffrey B. Shackelton ◽  
Rei Watanabe ◽  
Adam Calarese ◽  
Kei-ichi Yamanaka ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Skin Diseases ◽  
Cell Lymphoma ◽  
Early Stage ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Inflammatory Skin Diseases ◽  
Inflammatory Skin ◽  
Malignant T Cells

Abstract In early-stage cutaneous T-cell lymphoma (CTCL), malignant T cells are confined to skin and are difficult to isolate and discriminate from benign reactive cells. We found that T cells from CTCL skin lesions contained a population of large, high-scatter, activated skin homing T cells not observed in other inflammatory skin diseases. High-scatter T (THS) cells were CD4+ in CD4+ mycosis fungoides (MF), CD8+ in CD8+ MF, and contained only clonal T cells in patients with identifiable malignant Vβ clones. THS cells were present in the blood of patients with leukemic CTCL, absent in patients without blood involvement, and contained only clonal malignant T cells. The presence of clonal THS cells correlated with skin disease in patients followed longitudinally. Clonal THS cells underwent apoptosis in patients clearing on extracorporeal photopheresis but persisted in nonresponsive patients. Benign clonal T-cell proliferations mapped to the normal low-scatter T-cell population. Thus, the malignant T cells in both MF and leukemic CTCL can be conclusively identified by a unique scatter profile. This observation will allow selective study of malignant T cells, can be used to discriminate patients with MF from patients with other inflammatory skin diseases, to detect peripheral blood involvement, and to monitor responses to therapy.

An in-vitro model for the study of skin-homing T cells in inflammatory skin diseases

1998 ◽  
Vol 16 ◽  
pp. S174
Author(s):  
Karen Bang ◽  
Kirsten S. Pedersen ◽  
Tokuya Omi ◽  
Kristian Thestrup-Pedersen
Keyword(s):  
T Cells ◽  
In Vitro Model ◽  
Skin Diseases ◽  
Inflammatory Skin Diseases ◽  
Skin Homing ◽  
Inflammatory Skin ◽  
Vitro Model
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