scholarly journals Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice

2012 ◽  
Vol 132 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Mi Hee Kwack ◽  
Ji Sup Ahn ◽  
Moon Kyu Kim ◽  
Jung Chul Kim ◽  
Young Kwan Sung
Author(s):  
Abraham A. Embi

The human hair consists of a follicle anchored in the skin and a protruding shaft, it has also been described as a miniorgan, having its own cell divisions, metabolism, and known to undergo aging stages; eventually reaching a point where the old hair sheds and a new hair growing cycle begins from the same follicular tissue. Using sophisticated magnetometers, magnetic field emitted by direct current (DC) in human hair follicles were detected and introduced in 1980. Most recently in 2015, a tabletop optical microscopy method was developed and published in 2016, thus allowing for the detection of hair follicles and shaft magnetic fields. Qualitative images are presented where the bipolar electrical property of the shaft is documented. This finding was inferred since blood tissue carries a negative charge, thus repelled by an equal charge; experiments support a positive (+) field as triggering coagulation. The shaft is repeatedly shown in experiments to express a contralateral positive side triggering. Fibrin formation is also documented by images showing intricate networks indicative of blood coagulation. In conclusion, the genesis of hair shafts bipolarity is shown resulting from a “gap” in the follicle electromagnetic fields inhibiting energy from fully engulfing the shaft.


2015 ◽  
Vol 27 (6) ◽  
pp. 667 ◽  
Author(s):  
Hosein Rastegar ◽  
Hamidreza Ahmadi Ashtiani ◽  
Mahmoud Aghaei ◽  
Behrooz Barikbin ◽  
Amirohushang Ehsani

1988 ◽  
Vol 50 (2) ◽  
pp. 271-276 ◽  
Author(s):  
Ryuichiro KUWANA ◽  
Seiji ARASE ◽  
Yasushi SADAMOTO ◽  
Hideki NAKANISHI ◽  
Katsuyuki TAKEDA

Author(s):  
Ramya Lakshmi Rajendran ◽  
Prakash Gangadaran ◽  
Mi Hee Kwack ◽  
Ji Min Oh ◽  
Chae Moon Hong ◽  
...  

Author(s):  
Megan A. Palmer ◽  
Eleanor Smart ◽  
Iain S. Haslam

AbstractCholesterol has long been suspected of influencing hair biology, with dysregulated homeostasis implicated in several disorders of hair growth and cycling. Cholesterol transport proteins play a vital role in the control of cellular cholesterol levels and compartmentalisation. This research aimed to determine the cellular localisation, transport capability and regulatory control of cholesterol transport proteins across the hair cycle. Immunofluorescence microscopy in human hair follicle sections revealed differential expression of ATP-binding cassette (ABC) transporters across the hair cycle. Cholesterol transporter expression (ABCA1, ABCG1, ABCA5 and SCARB1) reduced as hair follicles transitioned from growth to regression. Staining for free cholesterol (filipin) revealed prominent cholesterol striations within the basement membrane of the hair bulb. Liver X receptor agonism demonstrated active regulation of ABCA1 and ABCG1, but not ABCA5 or SCARB1 in human hair follicles and primary keratinocytes. These results demonstrate the capacity of human hair follicles for cholesterol transport and trafficking. Future studies examining the role of cholesterol transport across the hair cycle may shed light on the role of lipid homeostasis in human hair disorders.


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