scholarly journals In Vivo Imaging of Human and Mouse Skin with a Handheld Dual-Axis Confocal Fluorescence Microscope

2011 ◽  
Vol 131 (5) ◽  
pp. 1061-1066 ◽  
Author(s):  
Hyejun Ra ◽  
Wibool Piyawattanametha ◽  
Emilio Gonzalez-Gonzalez ◽  
Michael J. Mandella ◽  
Gordon S. Kino ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Mouse Skin ◽  
Fluorescence Microscope ◽  
Confocal Fluorescence ◽  
Human And Mouse

In vivo imaging of mice auricle vessels using adaptive optical confocal fluorescence microscope

2015 ◽  
Vol 13 (11) ◽  
pp. 111702-111705 ◽  
Author(s):  
Yi He Yi He ◽  
Zhibin Wang Zhibin Wang ◽  
Yuanyuan Wang Yuanyuan Wang ◽  
Ling Wei Ling Wei ◽  
Xiqi Li Xiqi Li ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Fluorescence Microscope ◽  
Confocal Fluorescence

The top skin-associated genes: a comparative analysis of human and mouse skin transcriptomes

2014 ◽  
Vol 395 (6) ◽  
pp. 577-591 ◽  
Author(s):  
Peter Arne Gerber ◽  
Bettina Alexandra Buhren ◽  
Holger Schrumpf ◽  
Bernhard Homey ◽  
Albert Zlotnik ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Human Skin ◽  
Current Knowledge ◽  
Mouse Skin ◽  
Published Data ◽  
Healthy Human ◽  
Genome Wide ◽  
A Genome ◽  
Human And Mouse

Abstract The mouse represents a key model system for the study of the physiology and biochemistry of skin. Comparison of skin between mouse and human is critical for interpretation and application of data from mouse experiments to human disease. Here, we review the current knowledge on structure and immunology of mouse and human skin. Moreover, we present a systematic comparison of human and mouse skin transcriptomes. To this end, we have recently used a genome-wide database of human gene expression to identify genes highly expressed in skin, with no, or limited expression elsewhere – human skin-associated genes (hSAGs). Analysis of our set of hSAGs allowed us to generate a comprehensive molecular characterization of healthy human skin. Here, we used a similar database to generate a list of mouse skin-associated genes (mSAGs). A comparative analysis between the top human (n=666) and mouse (n=873) skin-associated genes (SAGs) revealed a total of only 30.2% identity between the two lists. The majority of shared genes encode proteins that participate in structural and barrier functions. Analysis of the top functional annotation terms revealed an overlap for morphogenesis, cell adhesion, structure, and signal transduction. The results of this analysis, discussed in the context of published data, illustrate the diversity between the molecular make up of skin of both species and grants a probable explanation, why results generated in murine in vivo models often fail to translate into the human.

scholarly journals Interspecific co-transfer of antibiotic resistance plasmids in staphylococciin vivo

1984 ◽  
Vol 93 (1) ◽  
pp. 59-66 ◽  
Author(s):  
Jay Naidoo
Keyword(s):  
Antibiotic Resistance ◽  
Resistance Genes ◽  
Mouse Skin ◽  
Resistance Plasmids ◽  
Gentamicin Resistance ◽  
Coagulase Positive Staphylococci ◽  
Human And Mouse

SUMMARYThe co-transfer of plasmid-borne genes governing resistance to gentamicin, tetracycline, erythromycin and chloramphenicol has been demonstrated on human and mouse skin. Two different gentamicin resistance plasmids have been studied in detail; both appear to have the ability to mobilizein vivootherwise non-transferable resistance plasmids from coagulase-negative to coagulase-positive staphylococci. This emphasises the role of the skin in maintaining a pool of resistance genes available to pathogenic staphylococci.

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