Association of G-protein β3 subunit C825T polymorphism with essential hypertension: evidence from 63 729 subjects

2017 ◽  
Vol 31 (8) ◽  
pp. 511-514 ◽  
Author(s):  
S-L Rong ◽  
J-Z Zheng ◽  
X-L Wang ◽  
C-Y Zhang ◽  
J Su ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
G Protein ◽  
C825t Polymorphism

C825T polymorphism in the G protein β3-Subunit gene is associated with seasonal affective disorder

2003 ◽  
Vol 54 (7) ◽  
pp. 682-686 ◽  
Author(s):  
Matthäus Willeit ◽  
Nicole Praschak-Rieder ◽  
Peter Zill ◽  
Alexander Neumeister ◽  
Manfred Ackenheil ◽  
...  
Keyword(s):  
Affective Disorder ◽  
G Protein ◽  
Seasonal Affective Disorder ◽  
Subunit Gene ◽  
C825t Polymorphism

Lack of association between the G protein ?3 subunit gene and essential hypertension in Chinese: a case-control and a family-based study

2003 ◽  
Vol 81 (11) ◽  
pp. 729-735 ◽  
Author(s):  
Xiaohong Huang ◽  
Zhenyu Ju ◽  
Yan Song ◽  
Hongye Zhang ◽  
Kai Sun ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
G Protein ◽  
Case Control ◽  
Subunit Gene ◽  
Family Based

scholarly journals Worldwide Ethnic Distribution of the G Protein β3 Subunit 825T Allele and Its Association with Obesity in Caucasian, Chinese, and Black African Individuals

1999 ◽  
Vol 10 (9) ◽  
pp. 1921-1930
Author(s):  
WINFRIED SIFFERT ◽  
PETER FORSTER ◽  
KARL-HEINZ JÖCKEL ◽  
DAVID A. MVERE ◽  
BERND BRINKMANN ◽  
...  
Keyword(s):  
G Protein ◽  
Young Male ◽  
Normal Weight ◽  
Allele Frequencies ◽  
Gene Encoding ◽  
Black Africans ◽  
Black African ◽  
South Africans ◽  
825T Allele ◽  
C825t Polymorphism

Abstract. Recently, it was demonstrated that one allele (825T) of the gene encoding the G protein β3 subunit (GNB3) is associated with hypertension in Germans. This study investigates a possible association with obesity in young male Germans, Chinese, and black South Africans with low, intermediate, and high 825T allele frequencies, respectively. In each of these three distinct cohorts, the 825T allele frequency was increased significantly in overweight (body mass index [BMI] ≥25 kg/m2) and obese individuals (BMI >27 kg/m2) compared to those with normal weight. The 825T allele frequencies in these three BMI groups were, respectively, 29.5, 39.3, and 47.7% in Germans, 46.8, 53.9, and 58.6% in Chinese, and 83.1, 87.7, and 90.9% in South Africans. In each of these three distinct groups, the 825T allele was significantly associated with obesity with odds ratios between 2 and 3. More urban than rural black Africans were overweight despite similar 825T allele frequencies in both populations, which underscores the role of both genetic and environmental factors. BP values in young male whites increased significantly with increasing BMI values but were independent of the C825T polymorphism, suggesting that hypertension associated with the 825T allele could be a consequence of obesity. Genotyping of 5254 individuals from 55 native population samples from Africa, the Americas, Europe, Asia, Australia, and New Guinea demonstrated highest 825T allele frequencies in black Africans (82%) and intermediate values in east Asians (47%). It is anticipated that high frequencies of the 825T allele in Africans and Asians may contribute to an obesity and hypertension epidemic if Westernization of lifestyles continues.

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