Serum uric acid is an independent predictor for developing prehypertension: a population-based prospective cohort study

2016 ◽  
Vol 31 (2) ◽  
pp. 116-120 ◽  
Author(s):  
L Liu ◽  
Y Gu ◽  
C Li ◽  
Q Zhang ◽  
G Meng ◽  
...  
Keyword(s):  
Uric Acid ◽  
Cohort Study ◽  
Serum Uric Acid ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Independent Predictor ◽  
Population Based

Serum Uric Acid Levels and Their Changes and Risk of Stroke: A 7-Year Prospective Cohort Study in Northwest China

2021 ◽  
pp. 1-10
Author(s):  
Shan Zheng ◽  
Yan Luo ◽  
Qian Miao ◽  
Zhiyuan Cheng ◽  
Yanli Liu ◽  
...  
Keyword(s):  
Uric Acid ◽  
Cohort Study ◽  
Serum Uric Acid ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Reference Group ◽  
Northwest China ◽  
Stroke Incidence ◽  
Increased Risk ◽  
Over Time

<b><i>Introduction:</i></b> It is not clear whether serum uric acid (SUA) levels and their changes over time are associated with the risk of stroke. A 7-year prospective cohort study in northwest China was conducted to analyze effects of SUA and their changes on the risk of stroke. <b><i>Methods:</i></b> A total of 23,262 individuals without cardiovascular disease in the Jinchang cohort were followed up for an average of 5.26 years. The Cox proportional hazard model was used to estimate the hazard ratios (HRs) and 95% confidence interval (95% CI) of stroke incidence to SUA and relative changes in SUA. Sensitivity analysis was performed after controlling the effect of renal insufficiency. <b><i>Results:</i></b> Baseline SUA and relative changes in SUA were positively correlated with the incidence of stroke in both males and females (<i>p</i> for overall association &#x3c;0.0001). Stroke risk increased by 4.6% per 10% increase in the relative change of SUA (HR = 1.046, 95% CI, 1.007–1.086). The fully adjusted regression analysis demonstrated that only the large gain (&#x3e;30%) in SUA was associated with an increased risk of stroke by 36.5% (95% CI, 1.8–83.0%), compared with the reference group (participants within ±10% changes in SUA). The same trend was observed in people with normal baseline SUA. In the unadjusted model, the risk of stroke associated with elevated SUA was significantly higher in the hyperuricemia group than in the normal SUA group. <b><i>Conclusion:</i></b> High initial SUA concentration and an increase in SUA concentration over time would increase the risk of stroke, and this means that there is no safe increase in SUA.

scholarly journals Serum uric acid levels and risk of kidney cancer incidence and mortality: A prospective cohort study

2020 ◽  
Vol 9 (15) ◽  
pp. 5655-5661
Author(s):  
Xiao‐Yu Dai ◽  
Qiang‐Sheng He ◽  
Zhong Jing ◽  
Jin‐Qiu Yuan
Keyword(s):  
Uric Acid ◽  
Cohort Study ◽  
Serum Uric Acid ◽  
Kidney Cancer ◽  
Prospective Cohort Study ◽  
Cancer Incidence ◽  
Prospective Cohort ◽  
Incidence And Mortality

scholarly journals Sex-specific association of serum uric acid dynamics with the incidence of metabolic syndrome in a health check-up Chinese population: a prospective cohort study

BMJ Open ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. e035289
Author(s):  
Ying Liu ◽  
Yongjun Fan ◽  
Qigui Liu ◽  
Kehua Liu ◽  
Fangfang Chen ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Cohort Study ◽  
Serum Uric Acid ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Health Check ◽  
Longitudinal Growth ◽  
Secondary Outcome ◽  
Dynamic Changes

ObjectiveMany studies have demonstrated that elevated serum uric acid (SUA) level is linked with metabolic syndrome (MetS). However, whether there is a sex difference in the association between SUA and MetS has not been determined. This study aimed to accurately explore the impact of SUA longitudinal changes on MetS by sex.DesignA prospective cohort study.SettingThe Health Check-up Centre of the Second Hospital affiliated with Dalian Medical University from 2010 to 2016.ParticipantsA health check-up cohort of 577 men and 1698 women aged 20–60 years who did not exhibit MetS or hyperuricaemia at baseline and underwent at least two physical examinations from 2010 to 2016.Primary and secondary outcome measuresWeight, height, blood pressure and blood biochemistry parameters, including SUA, were measured. MetS was defined according to the Joint Interim Statement criteria.MethodsBased on longitudinal data, a linear mixed-effects model was constructed to explore the characteristics of SUA dynamic changes in males and females, and joint modelling of longitudinal and survival data was done to analyse the association between SUA dynamic changes and MetS occurrence.ResultsThe natural logarithm of SUA (LNSUA) in females exhibited a gradually increasing trend, and its annual growth rate in females who developed MetS was greater than that of the non-MetS females. The longitudinal growth of SUA in females was a risk factor for the onset of MetS, and the estimated HR was 13.2580 (95% CI 1.9106 to 91.9957) for each 1-unit rise in LNSUA longitudinally. An association between the longitudinal growth of LNSUA and MetS was not found in males.ConclusionsThe longitudinal increase in SUA in females could increase the risk of MetS, even if the SUA changes within the normal range. The longitudinal increase in SUA in males was not a predictor for MetS.

Relationship between Serum Uric Acid and Mortality Risk in Hemodialysis Patients: A Multicenter Prospective Cohort Study

2020 ◽  
Vol 51 (10) ◽  
pp. 823-832
Author(s):  
Yaya Yang ◽  
Xianhui Qin ◽  
Yumin Li ◽  
Shenglin Yang ◽  
Junzhi Chen ◽  
...  
Keyword(s):  
Uric Acid ◽  
Cohort Study ◽  
Serum Uric Acid ◽  
Prospective Cohort Study ◽  
Mortality Risk ◽  
Prospective Cohort ◽  
All Cause Mortality ◽  
Multicenter Prospective Cohort Study ◽  
Multicenter Prospective Cohort ◽  
Cvd Mortality

<b><i>Background:</i></b> Several studies have reported that low serum uric acid (SUA) levels are related to increased risk of mortality in maintenance hemodialysis (MHD) patients. However, the possible detrimental effects of high SUA on the mortality risk have not been well examined. Moreover, the possible effect modifiers for the SUA-mortality association have not been fully investigated. To address the aforementioned gap, we aimed to explore the nonlinear relationship between SUA levels and all-cause and cardiovascular disease (CVD) mortality risk, and to examine any possible effect modifiers in MHD patients. <b><i>Methods:</i></b> We conducted a multicenter, prospective cohort study among 1,018 MHD patients from 8 hemodialysis centers. The primary outcome was all-cause mortality, and the secondary outcomes were CVD mortality and non-CVD mortality. <b><i>Results:</i></b> The mean value for SUA in the total population was 8.5 ± 1.9 mg/dL. The lowest and highest quintiles of SUA were &#x3c;7.0 and &#x3e;10.1 mg/dL, respectively. Over a median follow-up of 45.6 months, 343 deaths were recorded, of which 202 (58.9%) were due to CVD. When SUA was assessed as quintiles, a significantly higher risk of all-cause mortality was found in patients in quintile 1 (&#x3c;7.0 mg/dL; hazard ratio [HR], 1.33; 95% confidence interval [CI]: 1.02–1.73) or quintile 5 (≥10.1 mg/dL; HR, 1.47; 95% CI: 1.09–2.00), compared to those in quintiles 2–4 (7–10.1 mg/dL). Moreover, the U-shaped SUA-mortality association was mainly found in those with lower C-reactive protein levels (&#x3c;3 compared with ≥3 mg/L; <i>p</i> for interaction = 0.018). Similar trends were found for CVD mortality and non-CVD mortality. <b><i>Conclusion:</i></b> There was a U-shaped relationship between SUA levels and the risk of all-cause mortality, CVD mortality, and non-CVD mortality in MHD patients.

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