scholarly journals Early life stress and blood pressure levels in late adulthood

2012 ◽  
Vol 27 (2) ◽  
pp. 90-94 ◽  
Author(s):  
H Alastalo ◽  
K Räikkönen ◽  
A-K Pesonen ◽  
C Osmond ◽  
D J P Barker ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Late Adulthood

scholarly journals Hippocampal astroglial hypertrophy in mice subjected to early life maternal deprivation

2021 ◽  
Author(s):  
Arnab Nandi ◽  
Garima Virmani ◽  
Swananda Marathe
Keyword(s):  
Immune Responses ◽  
Life Stress ◽  
Early Life ◽  
Maternal Separation ◽  
Early Life Stress ◽  
Stratum Radiatum ◽  
Late Adulthood ◽  
Synaptic Physiology ◽  
And Behavior

Early-life stress (ELS), including chronic deprivation of maternal care, exerts persistent life-long effects on animal physiology and behavior, and is associated with several neurodevelopmental disorders. Long-lasting changes in neuronal plasticity and electrophysiology are documented extensively in the animal models of ELS. However, the role of astroglia in the lasting effects of ELS remains elusive. Astrocytes are intricately involved in the regulation of synaptic physiology and behavior. Moreover, astrocytes play a major role in the innate and adaptive immune responses in the central nervous system (CNS). The role of immune responses and neuroinflammation in the altered brain development and persistent adverse effects of ELS are beginning to be explored. Innate immune response in the CNS is characterized by a phenomenon called astrogliosis, a process in which astrocytes undergo hypertrophy, along with changes in gene expression and function. While the immune activation and neuroinflammatory changes concomitant with ELS, or in juveniles and young adults have been reported, it is unclear whether mice subjected to ELS exhibit astrogliosis-like alterations well into late-adulthood. Here, we subjected mice to maternal separation from postnatal day 2 to day 22 and performed comprehensive morphometric analysis of hippocampal astrocytes during late-adulthood. We found that the astrocytes in the stratum radiatum region of the CA1 hippocampal subfield from maternally separated mice exhibit significant hypertrophy as late as 8 months of age, revealing the crucial changes in astrocytes that manifest long after the cessation of ELS. This study highlights the persistence of neuroinflammatory changes in mice exposed to ELS.

Abstract 57: Histone Deacetylase Inhibition Attenuates Early Life Stress-Induced Endothelial Dysfunction

Hypertension ◽  
2012 ◽  
Vol 60 (suppl_1) ◽  
Author(s):  
Dao H Ho ◽  
Jennifer S Pollock
Keyword(s):  
Blood Pressure ◽  
Endothelial Dysfunction ◽  
Histone Deacetylase ◽  
Life Stress ◽  
Early Life ◽  
Maternal Separation ◽  
Trichostatin A ◽  
Early Life Stress ◽  
Intercellular Adhesion Molecule ◽  
Pressure Independent

Epidemiological studies show that early life stress (ELS) is linked to cardiovascular disease in adulthood. We used a model of maternal separation with early weaning (MSEW) to study the mechanisms of ELS-mediated adult vascular dysfunction in male C57BL/6J mice. MSEW litters were subjected to maternal separation 4h/day (postnatal day (PD) 2 to 5) and 8h/day (PD6 to 16), and weaned at PD17. Control (CON) litters were undisturbed until weaning at PD21. All subsequent experiments were performed in adult mice (12 weeks old). We hypothesized that MSEW increases vascular inflammation and endothelial dysfunction in male mice. Systolic blood pressure (tail-cuff) of MSEW mice was not different from CON mice (109.3 + 10.9 vs 116.7 + 20.8 mmHg, respectively). Circulating soluble intercellular adhesion molecule (CON: 333.5 + 19.4 vs MSEW: 406.2 + 23.1 ng/ml; p = 0.03) and macrophage colony stimulating factor (CON: 737.4 + 19.6 vs MSEW: 945.3 + 65.4 pg/ml; p = 0.01) were elevated by MSEW. Also, aortic adventitial macrophage infiltration was increased in mice exposed to MSEW (F4/80 immunostaining; CON: 2.8 + 2.3 vs MSEW: 7.0 + 2.2 cells/mm 2 ; p = 0.05). We performed wire myography on thoracic aortae to determine vasorelaxation with cumulative concentration-response curve to acetylcholine (ACh; 1 X 10 -9 M to 3 X 10 -5 M) and sodium nitroprusside (SNP; 1 X 10 -10 M to 3 X 10 -5 M). MSEW induced blunted ACh-mediated vasorelaxation (MSEW: 67.6 + 5.8 vs CON: 89.9 + 2.7 % of phenylephrine constriction (% of PE), p = 0.01), while SNP-induced vasorelaxation was similar in CON and MSEW mice. We further hypothesized that MSEW-induced endothelial dysfunction is mediated via increased histone deacetylase (HDAC) expression. Real-time quantitative PCR revealed upregulation of HDAC 1, 6 and 9 in aortae of MSEW mice (1.28 + 0.12, 1.28 + 0.18 and 1.65 + 0.05 fold change from CON, respectively, p < 0.05). Pretreatment with trichostatin A (TSA), an HDAC inhibitor, normalized ACh-induced vasorelaxation in aortae of MSEW mice (MSEW: 67.6 + 5.8 vs MSEW + TSA: 88.44 + 3.2 % of PE, p = 0.02), while not affecting ACh-induced vasorelaxation in aortae from CON mice (CON: 89.9 + 2.7 vs CON + TSA: 90.3 + 4.5 % of PE). We conclude that ELS induces blood pressure-independent endothelial dysfunction through an HDAC-mediated pathway.

scholarly journals Early Life Stress and Physical and Psychosocial Functioning in Late Adulthood

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e69011 ◽  
Author(s):  
Hanna Alastalo ◽  
Mikaela B. von Bonsdorff ◽  
Katri Räikkönen ◽  
Anu-Katriina Pesonen ◽  
Clive Osmond ◽  
...  
Keyword(s):  
Psychosocial Functioning ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Late Adulthood

Maternal verbally aggressive behavior in early infancy is associated with blood pressure at age 5–6

2018 ◽  
Vol 9 (3) ◽  
pp. 344-350
Author(s):  
L. J. C. A. Smarius ◽  
T. G. A. Strieder ◽  
T. A. H. Doreleijers ◽  
T. G. M. Vrijkotte ◽  
S. R. de Rooij
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Aggressive Behavior ◽  
Life Stress ◽  
Early Life ◽  
Negative Impact ◽  
Early Life Stress ◽  
Population Based ◽  
Early Infancy ◽  
Underlying Mechanisms

AbstractEarly life stress has been shown to contribute to alterations in biobehavioral regulation. Whereas many different forms of childhood adversities have been studied in relation to cardiovascular outcomes, very little is known about potential associations between caregivers’ verbally aggressive behavior and heart rate and blood pressure in the child. This prospective study examined whether maternal verbally aggressive behavior in early infancy is associated with heart rate or blood pressure at age 5–6. In the Amsterdam Born Children and their Development study, a large prospective, population-based birth cohort, maternal verbally aggressive behavior was assessed by questionnaire in the 13th week after birth. The child’s blood pressure and heart rate were measured during rest at age 5–6 (n=2553 included). Maternal verbally aggressive behavior in infancy was associated with a higher systolic blood pressure (SBP) both in supine and sitting position after adjustment for sex, height and age (SBP supine B=1.01 mmHg; 95% CI [0.06; 1.95] and SPB sitting B=1.29 mmHg; 95% CI [0.12; 2.46]). Adjustment for potential confounding variables, such as other mother–infant dyad aspects, family hypertension and child’s BMI, only slightly attenuated the associations (SBP supine B=0.99 mmHg; 95% CI [0.06; 1.93] and SPB sitting B=1.11 mmHg; 95% CI [−0.06; 2.27]). Maternal verbally aggressive behavior was not associated with diastolic blood pressure or heart rate at age 5–6. Maternal verbally aggressive behavior might be an important early life stressor with negative impact on blood pressure later in life, which should be further investigated. Possible underlying mechanisms are discussed.

scholarly journals The Impact of Early Life Stress on Anxiety Symptoms in Late Adulthood

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Anna Lähdepuro ◽  
Katri Savolainen ◽  
Marius Lahti-Pulkkinen ◽  
Johan G. Eriksson ◽  
Jari Lahti ◽  
...  
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Anxiety Symptoms ◽  
Late Adulthood ◽  
The Impact
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