scholarly journals The study of insulin resistance and soluble intercellular adhesion molecule-1 in normotensive adolescents with a family history of hypertension

2008 ◽  
Vol 23 (6) ◽  
pp. 402-406 ◽  
Author(s):  
Yin Fu-zai ◽  
Lu Qiang ◽  
Wang Shu-yi ◽  
Ma Chun-ming ◽  
Lou Dong-hui ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Family History ◽  
Adhesion Molecule ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1 ◽  
History Of ◽  
Soluble Intercellular Adhesion Molecule ◽  
Family History Of Hypertension

Intercellular Adhesion Molecule 1 (ICAM-1) Gene Variant Is Associated with Coronary Artery Calcification Independent of Soluble ICAM-1 Levels

2004 ◽  
Vol 52 (8) ◽  
pp. 515-522
Author(s):  
Muredach P. Reilly ◽  
Megan L. Wolfe ◽  
Jennifer Dykhouse ◽  
Karthik Reddy ◽  
Russell A. Localio ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery ◽  
Family History ◽  
Adhesion Molecule ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Gene Variant ◽  
Intercellular Adhesion Molecule 1 ◽  
History Of ◽  
Traditional Risk Factors

BackgroundAlthough circulating levels of soluble intercellular adhesion molecule 1 (sICAM-1) predict cardiovascular events, no studies have examined intercellular adhesion molecule 1 (ICAM-1) gene variants, plasma sICAM-1 levels, and atherosclerosis in the same sample.MethodsWe examined the association of the ICAM-1 K469E gene variant and plasma sICAM-1 with coronary artery calcification (CAC) in 632 asymptomatic subjects, recruited on the basis of a family history of premature cardiovascular disease.ResultsIn age-adjusted ordinal regression, sICAM-1 levels were associated with CAC (odds ratio [OR] [95% confidence interval (CI)] 1.30 [1.04-1.6] per 100 ng/dL sICAM-1; p = .02), but this association was lost after adjusting for traditional risk factors (OR [95% CI] 0.9 [0.69-1.16]). In men, but not women (interaction p = .018), the ICAM-1 K469E GG genotype predicted lower CAC after adjusting for traditional risk factors (OR [95% CI] 0.33 [0.17-0.61]; p = .001) and further controlling for plasma sICAM-1 (OR [95% CI] 0.27 [0.14-0.52]; p < .001).ConclusionsIn a study sample specifically selected for the characteristic of a family history of premature coronary heart disease, ICAM K469E GG was associated with lower CAC scores in men but not women even after controlling for plasma levels of sICAM-1. These studies suggest that ICAM-1 variants may modulate atherosclerosis in humans and provide support for the concept that inflammatory gene polymorphisms may influence atherosclerosis independent of plasma levels of their gene products.

scholarly journals Variability of Serum Soluble Intercellular Adhesion Molecule-1 Measurements Attributable to a Common Polymorphism

2004 ◽  
Vol 50 (11) ◽  
pp. 2185-2187 ◽  
Author(s):  
Thomas C Register ◽  
Kathryn P Burdon ◽  
Leon Lenchik ◽  
Donald W Bowden ◽  
Gregory A Hawkins ◽  
...  
Keyword(s):  
Adhesion Molecule ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1 ◽  
Common Polymorphism ◽  
Soluble Intercellular Adhesion Molecule

scholarly journals Soluble intercellular adhesion molecule-1 is a prognostic marker in colorectal carcinoma

2018 ◽  
Vol 34 (2) ◽  
pp. 309-317 ◽  
Author(s):  
Vera S. Schellerer ◽  
Melanie C. Langheinrich ◽  
Veronika Zver ◽  
Robert Grützmann ◽  
Michael Stürzl ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Prognostic Marker ◽  
Adhesion Molecule ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1 ◽  
Soluble Intercellular Adhesion Molecule
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