scholarly journals Role of rare variants in undetermined multiple adenomatous polyposis and early-onset colorectal cancer

2012 ◽  
Vol 57 (11) ◽  
pp. 709-716 ◽  
Author(s):  
Jérémie H Lefevre ◽  
Carolina Bonilla ◽  
Chrystelle Colas ◽  
Bruce Winney ◽  
Elaine Johnstone ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Early Onset ◽  
Rare Variants ◽  
Adenomatous Polyposis ◽  
Early Onset Colorectal Cancer

Systematic search for rare variants in Finnish early-onset colorectal cancer patients

2015 ◽  
Vol 208 (1-2) ◽  
pp. 35-40 ◽  
Author(s):  
Tomas Tanskanen ◽  
Alexandra E. Gylfe ◽  
Riku Katainen ◽  
Minna Taipale ◽  
Laura Renkonen-Sinisalo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Early Onset ◽  
Rare Variants ◽  
Systematic Search ◽  
Colorectal Cancer Patients ◽  
Early Onset Colorectal Cancer

scholarly journals The Role of Diet and Lifestyle in Early-Onset Colorectal Cancer: A Systematic Review

Cancers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 5933
Author(s):  
Marta Puzzono ◽  
Alessandro Mannucci ◽  
Simone Grannò ◽  
Raffaella Alessia Zuppardo ◽  
Andrea Galli ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Systematic Review ◽  
Young Adults ◽  
Early Onset ◽  
Current Evidence ◽  
Exogenous Factors ◽  
Diet And Lifestyle ◽  
Early Onset Colorectal Cancer

The incidence of early-onset colorectal cancer, defined as colorectal cancer occurring in young adults under the age of 50, is increasing globally. Knowledge of the etiological factors in young adults is far from complete. Questionable eoCRCs’ exogenous factors are represented by processed meat, sugary drinks, alcohol, Western dietary pattern, overweight and obesity, physical inactivity, and smoking, though with heterogeneous results. Therefore, we performed a systematic review to summarize the current evidence on the role of diet and lifestyle as eoCRC risk factors. We systematically searched PubMed, Scopus, and EMBASE up to July 2021, for original studies evaluating diet, alcohol, physical activity, BMI, and smoking in eoCRC and included twenty-six studies. Indeed, the exogenous factors could represent modifiable key factors, whose recognition could establish areas of future interventions through public health strategies for eoCRC primary prevention. Additionally, we discussed the role of additional non-modifiable risk factors, and of epigenetic regulation and microbiota as mediators of the eoCRC triggered by diet and lifestyle.

scholarly journals Gut Dysbiosis and Intestinal Barrier Dysfunction: Potential Explanation for Early-Onset Colorectal Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Siti Maryam Ahmad Kendong ◽  
Raja Affendi Raja Ali ◽  
Khairul Najmi Muhammad Nawawi ◽  
Hajar Fauzan Ahmad ◽  
Norfilza Mohd Mokhtar
Keyword(s):  
Colorectal Cancer ◽  
Environmental Factors ◽  
Gut Microbiota ◽  
Early Onset ◽  
Early Stage ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Gut Dysbiosis ◽  
Early Onset Colorectal Cancer

Colorectal cancer (CRC) is a heterogeneous disease that commonly affects individuals aged more than 50 years old globally. Regular colorectal screening, which is recommended for individuals aged 50 and above, has decreased the number of cancer death toll over the years. However, CRC incidence has increased among younger population (below 50 years old). Environmental factors, such as smoking, dietary factor, urbanization, sedentary lifestyle, and obesity, may contribute to the rising trend of early-onset colorectal cancer (EOCRC) because of the lack of genetic susceptibility. Research has focused on the role of gut microbiota and its interaction with epithelial barrier genes in sporadic CRC. Population with increased consumption of grain and vegetables showed high abundance of Prevotella, which reduces the risk of CRC. Microbes, such as Fusobacterium nucleatum, Bacteroides fragilis and Escherichia coli deteriorate in the intestinal barrier, which leads to the infiltration of inflammatory mediators and chemokines. Gut dysbiosis may also occur following inflammation as clearly observed in animal model. Both gut dysbiosis pre- or post-inflammatory process may cause major alteration in the morphology and functional properties of the gut tissue and explain the pathological outcome of EOCRC. The precise mechanism of disease progression from an early stage until cancer establishment is not fully understood. We hypothesized that gut dysbiosis, which may be influenced by environmental factors, may induce changes in the genome, metabolome, and immunome that could destruct the intestinal barrier function. Also, the possible underlying inflammation may give impact microbial community leading to disruption of physical and functional role of intestinal barrier. This review explains the potential role of the interaction among host factors, gut microenvironment, and gut microbiota, which may provide an answer to EOCRC.

scholarly journals The role of SMAD4 in early-onset colorectal cancer

2010 ◽  
Vol 12 (3) ◽  
pp. 213-219 ◽  
Author(s):  
S. G. Royce ◽  
K. Alsop ◽  
A. Haydon ◽  
L. Mead ◽  
L. D. Smith ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Early Onset ◽  
Early Onset Colorectal Cancer

Mo1607 Role of Environmental Risk Factors on Early-Onset Colorectal Cancer Risk

2012 ◽  
Vol 142 (5) ◽  
pp. S-640
Author(s):  
Aung Ko Win ◽  
Sergio A. Taunde ◽  
Joanne P. Young ◽  
Daniel D. Buchanan ◽  
Driss Ait Ouakrim ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Cancer Risk ◽  
Environmental Risk ◽  
Early Onset ◽  
Environmental Risk Factors ◽  
Colorectal Cancer Risk ◽  
Early Onset Colorectal Cancer

scholarly journals Cyclin D1 rare variants in UK multiple adenoma and early-onset colorectal cancer patients

2010 ◽  
Vol 56 (1) ◽  
pp. 58-63 ◽  
Author(s):  
Carolina Bonilla ◽  
Jérémie H Lefèvre ◽  
Bruce Winney ◽  
Elaine Johnstone ◽  
Susan Tonks ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cyclin D1 ◽  
Cancer Patients ◽  
Early Onset ◽  
Rare Variants ◽  
Colorectal Cancer Patients ◽  
Early Onset Colorectal Cancer ◽  
Multiple Adenoma

scholarly journals Antioxidants Promote Intestinal Tumor Progression in Mice

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 241
Author(s):  
Zhiyuan V. Zou ◽  
Kristell Le Gal ◽  
Ahmed E. El Zowalaty ◽  
Lara E. Pehlivanoglu ◽  
Viktor Garellick ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Colorectal Cancer ◽  
Tumor Progression ◽  
Human Subjects ◽  
Plasma Concentrations ◽  
Intestinal Tumor ◽  
Adenomatous Polyposis ◽  
Intestinal Tumors ◽  
The Impact

Dietary antioxidants and supplements are widely used to protect against cancer, even though it is now clear that antioxidants can promote tumor progression by helping cancer cells to overcome barriers of oxidative stress. Although recent studies have, in great detail, explored the role of antioxidants in lung and skin tumors driven by RAS and RAF mutations, little is known about the impact of antioxidant supplementation on other cancers, including Wnt-driven tumors originating from the gut. Here, we show that supplementation with the antioxidants N-acetylcysteine (NAC) and vitamin E promotes intestinal tumor progression in the ApcMin mouse model for familial adenomatous polyposis, a hereditary form of colorectal cancer, driven by Wnt signaling. Both antioxidants increased tumor size in early neoplasias and tumor grades in more advanced lesions without any impact on tumor initiation. Importantly, NAC treatment accelerated tumor progression at plasma concentrations comparable to those obtained in human subjects after prescription doses of the drug. These results demonstrate that antioxidants play an important role in the progression of intestinal tumors, which may have implications for patients with or predisposed to colorectal cancer.

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