scholarly journals Intracranial Pressure Elevation after Ischemic Stroke in Rats: Cerebral Edema is not the only Cause, and Short-Duration Mild Hypothermia is a Highly Effective Preventive Therapy

2015 ◽  
Vol 35 (12) ◽  
pp. 2109-2109 ◽  
Author(s):  
Lucy A Murtha ◽  
Damian D McLeod ◽  
Debbie Pepperall ◽  
Sarah K McCann ◽  
Daniel J Beard ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Intracranial Pressure ◽  
Short Duration ◽  
Cerebral Edema ◽  
Mild Hypothermia ◽  
Preventive Therapy ◽  
Pressure Elevation ◽  
Highly Effective ◽  
Intracranial Pressure Elevation

scholarly journals Intracranial Pressure Elevation after Ischemic Stroke in Rats: Cerebral Edema is Not the Only Cause, and Short-Duration Mild Hypothermia is a Highly Effective Preventive Therapy

2014 ◽  
Vol 35 (4) ◽  
pp. 592-600 ◽  
Author(s):  
Lucy A Murtha ◽  
Damian D McLeod ◽  
Debbie Pepperall ◽  
Sarah K McCann ◽  
Daniel J Beard ◽  
...  
Keyword(s):  
Intracranial Pressure ◽  
Short Duration ◽  
Cerebral Edema ◽  
Mild Hypothermia ◽  
Dry Weight ◽  
Preventive Therapy ◽  
Stroke Onset ◽  
Experimental Stroke ◽  
Moderate Hypothermia ◽  
Intracranial Pressure Elevation

In both the human and animal literature, it has largely been assumed that edema is the primary cause of intracranial pressure (ICP) elevation after stroke and that more edema equates to higher ICP. We recently demonstrated a dramatic ICP elevation 24 hours after small ischemic strokes in rats, with minimal edema. This ICP elevation was completely prevented by short-duration moderate hypothermia soon after stroke. Here, our aims were to determine the importance of edema in ICP elevation after stroke and whether mild hypothermia could prevent the ICP rise. Experimental stroke was performed in rats. ICP was monitored and short-duration mild (35 °C) or moderate (32.5 °C) hypothermia, or normothermia (37 °C) was induced after stroke onset. Edema was measured in three studies, using wet—dry weight calculations, T2-weighted magnetic resonance imaging, or histology. ICP increased 24 hours after stroke onset in all normothermic animals. Short-duration mild or moderate hypothermia prevented this rise. No correlation was seen between ΔICP and edema or infarct volumes. Calculated rates of edema growth were orders of magnitude less than normal cerebrospinal fluid production rates. These data challenge current concepts and suggest that factors other than cerebral edema are the primary cause of the ICP elevation 24 hours after stroke onset.

scholarly journals Forecasting intracranial pressure elevation using pulse waveform morphology

2009 ◽  
Author(s):  
R. Hamilton ◽  
Peng Xu ◽  
S. Asgari ◽  
M. Kasprowicz ◽  
P. Vespa ◽  
...  
Keyword(s):  
Intracranial Pressure ◽  
Pulse Waveform ◽  
Pressure Elevation ◽  
Intracranial Pressure Elevation

scholarly journals Frequency of Sustained Intracranial Pressure Elevation during Treatment of Severe Intraventricular Hemorrhage

2009 ◽  
Vol 27 (4) ◽  
pp. 403-410 ◽  
Author(s):  
Wendy C. Ziai ◽  
Michel T. Torbey ◽  
Neal J. Naff ◽  
Michael A. Williams ◽  
Ross Bullock ◽  
...  
Keyword(s):  
Intracranial Pressure ◽  
Intraventricular Hemorrhage ◽  
Pressure Elevation ◽  
Intracranial Pressure Elevation

scholarly journals Short-Duration Hypothermia after Ischemic Stroke Prevents Delayed Intracranial Pressure Rise

2013 ◽  
Vol 9 (5) ◽  
pp. 553-559 ◽  
Author(s):  
L. A. Murtha ◽  
D. D. McLeod ◽  
S. K. McCann ◽  
D. Pepperall ◽  
S. Chung ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Intracranial Pressure ◽  
Short Duration ◽  
Pressure Rise
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