scholarly journals Cerebral Autoregulation and Brain Networks in Occlusive Processes of the Internal Carotid Artery

2014 ◽  
Vol 35 (2) ◽  
pp. 240-247 ◽  
Author(s):  
Keren Avirame ◽  
Anne Lesemann ◽  
Jonathan List ◽  
Anja Veronica Witte ◽  
Stephan Joachim Schreiber ◽  
...  
Keyword(s):  
White Matter ◽  
Functional Connectivity ◽  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Cerebral Autoregulation ◽  
Internal Carotid ◽  
Brain Networks ◽  
Transcranial Doppler Sonography ◽  
Vasomotor Reactivity ◽  
White Matter Microstructure

Patients with unilateral occlusive processes of the internal carotid artery (ICA) show subtle cognitive deficits. Decline in cerebral autoregulation and in functional and structural integrity of brain networks have previously been reported in the affected hemisphere (AH). However, the association between cerebral autoregulation, brain networks, and cognition remains to be elucidated. Fourteen neurologically asymptomatic patients (65±11 years) with either ICA occlusion or high-grade ICA stenosis and 11 age-matched healthy controls (HC) (67±6 years) received neuropsychologic testing, transcranial Doppler sonography to assess cerebral autoregulation using vasomotor reactivity (VMR), and magnetic resonance imaging to probe white matter microstructure and resting-state functional connectivity (RSFC). Patients performed worse on memory and executive tasks when compared with controls. Vasomotor reactivity, white matter microstructure, and RSFC were lower in the AH of the patients when compared with the unaffected hemisphere and with controls. Lower VMR of the AH was associated with several ipsilateral clusters of lower white matter microstructure and lower bilateral RSFC in patients. No correlations were found between VMR and cognitive scores. In sum, impaired cerebral autoregulation was associated with reduced structural and functional connectivity in cerebral networks, indicating possible mechanisms by which severe unilateral occlusive processes of the ICA lead to cognitive decline.

Carbon Dioxide Vasomotor Reactivity of the Infraclinoid Internal Carotid Artery

2004 ◽  
Vol 16 (4) ◽  
pp. 332-333
Author(s):  
Chan MTV ◽  
Ng S ◽  
Sun D ◽  
Lam JMK ◽  
Poon WS ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Internal Carotid ◽  
Vasomotor Reactivity

Abstract TP205: Association Between Morphological Variations of Extracranial Internal Carotid Artery and Cerebral White Matter Hyperintensities

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Yuying Yan ◽  
Bo Wu ◽  
Yirui Cao ◽  
Shuai Jiang ◽  
Jiayu Sun
Keyword(s):  
White Matter ◽  
Carotid Artery ◽  
Blood Vessel ◽  
Internal Carotid Artery ◽  
White Matter Hyperintensities ◽  
Internal Carotid ◽  
Cerebral White Matter ◽  
Extracranial Internal Carotid Artery ◽  
Morphological Variations ◽  
History Of

Background: Cerebral white matter hyperintensities (WMHs) often remain asymptomatic until they widely affect brain structure. The association between small and large vessel diseases is worth studying. We aimed to explore the relationship between morphological variations of extracranial internal carotid artery (EICA) and WMHs. The classic evaluation system of artery variations failed to describe the compound abnormities, and therefore some novel parameters were proposed in this study. Methods: Neck CT angiography scans and brain MRI data of 97 patients with acute ischemic stroke were retrospectively analyzed. The angle of EICA, tortuosity index (TI), deviation degree (DD) and angular number (AN) were measured as parameters of artery morphological variations (Figure). The severity of WMHs was assessed by Fazekas Scale. Differences of vascular morphological variations between mild and severe white matter lesion groups and factors independently associated with WMHs were analyzed. Results: Compared with the patients with mild WMHs, patients with severe WMHs were older ( P =0.001), had higher average systolic blood pressure ( P =0.026), larger median TI ( P <0.001) and median DD ( P <0.001). Also, more patients with severe WMHs had sharp blood vessel angles ( P =0.001) and history of stroke ( P =0.034). Sharp blood vessel angle (OR 4.056, 95%CI 1.578-10.467) and TI (OR 1.037, 95%CI 1.007-1.068) were independently associated with severe WMHs proved by multivariate logistic analysis. Several regression models suggested that age and history of stroke had close relationship with WMHs. Conclusions: Sharp angle of EICA and TI were independently associated with severe WMHs. Besides, age and history of stroke were firmly related to white matter lesions.

Differentiation of gray matter and white matter perfusion in patients with unilateral internal carotid artery occlusion

1998 ◽  
Vol 8 (4) ◽  
pp. 767-774 ◽  
Author(s):  
Manon Kluytmans ◽  
Jeroen van der Grond ◽  
Paul J. M. Folkers ◽  
Willem P. Th. M. Mali ◽  
Max A. Viergever
Keyword(s):  
White Matter ◽  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Gray Matter ◽  
Internal Carotid ◽  
Artery Occlusion ◽  
Carotid Artery Occlusion ◽  
Internal Carotid Artery Occlusion

Cortical Reorganization Due to Impaired Cerebral Autoregulation in Individuals With Occlusive Processes of the Internal Carotid Artery

2014 ◽  
Vol 7 (3) ◽  
pp. 381-387 ◽  
Author(s):  
Jonathan List ◽  
Susan Hertel-Zens ◽  
Jan Carl Kübke ◽  
Anne Lesemann ◽  
Stephan J. Schreiber ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Cerebral Autoregulation ◽  
Internal Carotid ◽  
Cortical Reorganization

scholarly journals Internal Carotid Artery Occlusion in Systemic Lupus Erythematosus as a Potential Mimicker of Multiple Sclerosis

2017 ◽  
Vol 9 (1) ◽  
pp. 86-90 ◽  
Author(s):  
Kenichiro Sato ◽  
Mami Kanzaki ◽  
Yoshifumi Ubara ◽  
Yoshikazu Uesaka
Keyword(s):  
Multiple Sclerosis ◽  
Systemic Lupus Erythematosus ◽  
White Matter ◽  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Lupus Erythematosus ◽  
Internal Carotid ◽  
White Matter Lesions ◽  
Systemic Lupus ◽  
Neuropsychiatric Sle

The diagnosis of neurological symptoms in patients with systemic lupus erythematosus (SLE) is often challenging, in part because they sometimes mimic features of multiple sclerosis (MS). Herein we report a case of a young female who presented with relapsing-remitting symptoms of unilateral visual loss and motor aphasia. Additionally, radiological findings revealed multiple white matter lesions on her brain that led to an initial diagnosis of MS based on the established diagnostic criteria. However, she was eventually diagnosed with neuropsychiatric SLE (NPSLE) presenting with extracranial internal carotid artery (ICA) occlusion. Her ICA occlusion had not been detected for 2 months until she underwent magnetic resonance angiography. Although exact underlying pathological mechanisms are unclear, both the ICA occlusion and MS-like brain white matter lesions could be attributed to SLE. This case demonstrated that both of these lesions can coexist in the same patient, suggesting that NPSLE with ICA occlusion can be a potential mimicker of MS, and vice versa. Care must be paid to avoid delay in the diagnosis.

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